Markers of Iron Status Are Associated with Risk of Hyperuricemia among Chinese Adults: Nationwide Population-Based Study

Li, Xiangping; He, Tao; Yu, Kai; Lü, Qian; Alkasir, Rashad; Guo, Guifang; Xue, Yong

doi:10.3390/nu10020191

Cited by 36 publications

(34 citation statements)

References 71 publications

(103 reference statements)

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“…Brain iron content is associated with cognitive decline (39,40) and amyloid deposition, which has been associated with neurodegenerative disorders (41). Furthermore, high iron status as indicated by serum ferritin, transferrin, and hemoglobin concentrations has been shown to be positively associated with increased risk of hyperuricemia among participants of the CHNS (42). Moreover, hyperuricemia is related to poor cognitive function in the Chinese population (43).…”

Section: Discussionmentioning

confidence: 99%

High iron intake is associated with poor cognition among Chinese old adults and varied by weight status—a 15-y longitudinal study in 4852 adults

Shi

Wang

et al. 2019

The American Journal of Clinical Nutrition

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Background High body iron status has been shown to be associated with adverse health outcomes. However, the relation between high body iron status, body mass index (BMI), and cognition is still understudied. Objective This study aimed to examine the association between iron intake and cognitive function in Chinese adults and tested the interaction effect of iron intake and BMI on cognition. Design Longitudinal study data from a nationwide sample (n = 4852; age ≥55 y) from the China Health and Nutrition Survey during 1991–2006 were used. Of the participants, 3302 had completed cognitive screening tests in ≥2 surveys. Cognitive function was assessed in 1997, 2000, 2004, and 2006. Dietary iron intake was obtained from a 3-d food record during home visits in 1991, 1993, 1997, 2000, 2004, and 2006. Multivariable mixed linear regression and logistic regression were used. Results The cumulative mean ± SD iron intake in 1997 of tested subjects was 23.7 ± 11.3 mg/d (25.4 mg/d in men and 22.2 mg/d in women). High iron intake was associated with poor cognition. In fully adjusted models, across the quartiles of iron intake the regression coefficients (95% CIs) were 0, −0.39 (−0.77, −0.01), −0.55 (−0.95, −0.15), and −0.90 (−1.33, −0.47), respectively. Comparing extreme quartiles of iron intake (high), the OR (95% CI) for poor cognitive function was 1.30 (1.04, 1.64). There was a significant interaction between iron intake and BMI. The association between high iron intake and poor cognition was stronger among those with a high BMI than those with a low BMI. Among those with a BMI (kg/m2) >24, across quartiles of iron intake the ORs (95% CIs) for poor cognitive function were 1.00, 1.27 (0.91, 1.78), 1.41 (0.97, 2.04), and 2.04 (1.38, 3.01), respectively. Conclusion Higher iron intake is associated with poor cognition in Chinese adults, especially among those with a high BMI.

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Section: Discussionmentioning

confidence: 99%

High iron intake is associated with poor cognition among Chinese old adults and varied by weight status—a 15-y longitudinal study in 4852 adults

Shi

Wang

et al. 2019

The American Journal of Clinical Nutrition

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“…The blood samples in red-stoppered tube (4 mL) were centrifuged at 3000 × g for 15 min at room temperature; serum samples were frozen and stored at −86 • C for the subsequent laboratory analysis. According to strict quality control standards, all samples were verified and analyzed in a national central laboratory in Beijing (Medical laboratory accreditation certificate: ISO 15189:2007) [31]. TG in serum was analyzed by the glycerol-3-phosphate oxidase-phenol and aminophenazone GPO-PAP method, HDL-C and low-density lipoprotein cholesterol (LDL-C) by enzymatic method, total cholesterol (TC) by the cholesterol oxidase-phenol and aminophenazone (CHOD-PAP) method, and fasting blood glucose by glucose oxidase-phenol and aminophenazone (GOD-PAP) method.…”

Section: Anthropometric Measurements and Serum Biochemical Parametersmentioning

confidence: 99%

The Visceral Adipose Index in Relation to Incidence of Hypertension in Chinese Adults: China Health and Nutrition Survey (CHNS)

Xue

Dai

et al. 2020

Nutrients

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Hypertension is the most crucial single contributor to global burden of disease and mortality, while weight loss as a non-pharmacological strategy is recommended to reduce blood pressure. This study aims to examine the association between visceral adipose index (VAI) and hypertension in Chinese adults. Data were collected from the China Health and Nutrition Survey (CHNS), consisting of 8374 apparently healthy participants aged ≥18 years in the 2009 CHNS for cross-sectional analysis, and 4275 participants at entry from 2009 to 2011 for cohort analysis. Height, weight, waist circumference, blood pressure (BP), and blood lipid were measured. Information of population characteristics, smoking status, alcohol consumption, physical activity, and diet were determined by validated questionnaire. Higher VAI scores were significantly associated with higher BP levels and higher risk of hypertension after adjustment with potential confounders (all p-trend < 0.001). The adjusted hazard ratio of hypertension was 1.526 (95%CI: 1.194, 1.952; p-trend < 0.01) for participants in the highest quartile of VAI scores when compared with those in the lowest quartile after adjustment for age, physical activity, antihypertensive medication, total energy intake, salt intake, and other major lifestyle factors. VAI scores were significantly, longitudinally associated with hypertension development among apparently healthy Chinese adults.

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“…Blood samples were taken in the morning after at least 12 h of night fasting. As depicted elsewhere (13), all samples were validated and analyzed in accordance with strict quality control standards (17,18) at the National Center Laboratory (Medical Laboratory Accreditation Certificate ISO 15189:2007) in Beijing. Methods of measuring iron markers have been depicted in detail in previous studies (19,20).…”

Section: Laboratory Data Measurementmentioning

confidence: 99%

“…Serum ferritin (SF), soluble transferrin receptor (sTfR), hemoglobin (Hb), and transferrin are the most widely used clinical biomarkers of iron. Previous publications have reported the relationships between these markers with hypertension (12), hyperuricemia (13), stroke (14), and diabetes (15). However, there are limited studies evaluating whether iron levels are associated with estimated glomerular filtration rate (eGFR)/CKD in general population.…”

Section: Introductionmentioning

confidence: 99%

Association Between Iron Status and Risk of Chronic Kidney Disease in Chinese Adults

Zhu

Liu

et al. 2020

Front. Med.

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Background: Even though it is well-known that iron deficiency is the result of chronic kidney disease (CKD), whether iron will affect kidney function and disease in the general population is not clear. We thus conducted a nationwide cross-sectional study using data from the China Health and Nutrition Survey (CHNS) to assess the relationship of iron status with estimated glomerular filtration rate (eGFR) and CKD among general adults. Methods: A total of 8,339 adults from the China Health and Nutrition Survey in the wave of 2009 were included to assess the association between iron status and eGFR/CKD. Serum ferritin (SF), transferrin, soluble transferrin receptor (sTfR), and hemoglobin (Hb) were measured. The relationship of iron status and eGFR was evaluated by using multi-variable linear regression model. The effect of iron status on the odds of CKD was calculated by logistic regression model. Results: For the association between iron status and eGFR, every 100 µg/L increase in SF was correlated with 0.26 ml/min per 1.73 m² (95% CI: 0.08-0.44) decrease in eGFR, and every 5 mg/L increase in sTfR was associated with a decrease of 6.00 ml/min per 1.73 m² (95% CI: 3.79-8.21) in eGFR. There were no significant associations between Hb or transferrin with eGFR. For the association between iron status and CKD, every 5 g/L increase in sTfR was associated with an odds ratio of 3.72 (95% CI: 2.16-6.13) for CKD. The concentrations of Hb were associated with the odds of CKD in a U-shaped manner, with the lowest risk in the Hb range of 136-141 g/L. There was a positive correlation between SF concentration and CKD prevalence but not in a dose-response manner. The odds of CKD for participants in the highest tertile increased by 28% (98% CI: 1-63%) compared with those in the lowest tertile. Conclusion: The concentration of SF and sTfR was positively correlated with the odds of CKD, and Hb was associated with the odds of CKD in a U-shaped manner. Further large prospective researches are warranted to confirm these findings.

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Markers of Iron Status Are Associated with Risk of Hyperuricemia among Chinese Adults: Nationwide Population-Based Study

Cited by 36 publications

References 71 publications

High iron intake is associated with poor cognition among Chinese old adults and varied by weight status—a 15-y longitudinal study in 4852 adults

High iron intake is associated with poor cognition among Chinese old adults and varied by weight status—a 15-y longitudinal study in 4852 adults

The Visceral Adipose Index in Relation to Incidence of Hypertension in Chinese Adults: China Health and Nutrition Survey (CHNS)

Association Between Iron Status and Risk of Chronic Kidney Disease in Chinese Adults

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