Markers of insulin resistance in day and shift workers aged 30-59 years

Noguchi, Teruo; Yoshida, Hideyo; Takahashi, Hidekatsu; Kikuchi, Makoto

doi:10.1007/s00420-002-0370-0

Cited by 139 publications

(95 citation statements)

References 33 publications

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“…Such results were similar to that of Di Lorenzo et al (2003) who examined the influence of shift work on metabolic and cardiovascular risk factors among subjects working in a chemical industry in southern Italy and found that shift workers had higher glucose levels (Di Lorenzo et al, 2003). In another crosssectional study of Japanese male blue collar workers, Nagaya et al (2002) reported that shift workers were more likely than day-time workers to have high fasting serum glucose (Nagaya et al, 2002). Additionally, a study by Ye et al (2013) reported similar associations between shift work and the metabolic syndrome in female workers from the Daegu area Dyeing Industrial Complex, Korea, and found that the shift work group had significantly higher FBS levels.…”

Section: Discussionsupporting

confidence: 83%

Night Shift Working and Its Impact on Development and Control of Diabetes Mellitus in Workers of Abo Korkas Sugar Factory, El-Minia, Egypt

et al. 2014

Egypt. J. Occup. Med.

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Introduction: Rotating night shift work disrupts circadian rhythms and it has been associated with chronic conditions including cancers, cardiovascular diseases, obesity, metabolic syndrome and glucose dysregulation. Aim of work: the study aimed at determining the prevalence of glucose abnormalities among Abo-Korkas sugar factory workers and exploring the impact of rotating night shifts on glycemic state and control of diabetes. Materials and Methods: In a cross-sectional study a total of 330 male workers at Abo-Korkas sugar factory were randomly selected to fill out an interview questionnaire, have medical examination and be tested for fasting and post-prandial blood glucose level; with assessment of HbA1c (Hemoglobin A1c test) for those who were diagnosed as diabetics. Results: Our findings showed that 61 (18.4%) workers were diabetics, 7 of them were newly diagnosed diabetics. The prevalence of diabetes was significantly higher (p= 0.01) among former (33.3%) and current (15.7%) night shift than day-time workers (14.4%). The crude Odds Ratio (OR) for developing diabetes mellitus among the current and former shift workers were 1.1 (0.56-2.18) and 2.9 (1.39-6.31), respectively. Moreover, shift working significantly affected diabetes control (p= 0.04) with an OR= 3.83 (1.02-14.34). Conclusion: Rotating shift work especially night shifts have negative effects on health. It was found to be associated with developing type 2 diabetes mellitus and it hindered diabetes control among night shift diabetic workers. Preventive programs should be implemented for high risk employees. Occupational health practitioners should be aware of such associations that will help them in prevention and management of diabetic employees.

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Section: Discussionsupporting

confidence: 83%

Night Shift Working and Its Impact on Development and Control of Diabetes Mellitus in Workers of Abo Korkas Sugar Factory, El-Minia, Egypt

et al. 2014

Egypt. J. Occup. Med.

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“…Disruption of these processes is exemplified by the extreme circumstances of reversal of day/night working patterns seen in some shift workers. Lund et al [40] reported that maladaption of endogenous circadian rhythms in shift workers was associated with increased insulin resistance and elevated postprandial triglyceride levels, findings consistent with other studies in this field [44][45][46][47]. In addition, shift work is associated with an increased risk of cardiovascular disease [46,47], reported in one study as conveying a 1.6-and 3.0-fold increased risk for men and women, respectively, in the 45-55 year age group [46,48].…”

Section: Man Diabetes and Cardiovascular Diseasementioning

confidence: 57%

Neel revisited: the adipocyte, seasonality and type 2 diabetes

Scott

Grant

2006

Diabetologia

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The modern epidemic of obesity and insulin resistance with cardiovascular risk factor clustering is related to the development of type 2 diabetes and cardiovascular disease. Over 40 years ago, Neel postulated that insulin resistance should confer survival benefit. Extrapolating Neel's hypothesis, we propose that the cluster of associated abnormalities also confers survival benefit and is related to metabolic responses seen in seasonally responsive animals. Weight gain in preparation for winter is accompanied by a range of acute metabolic changes virtually identical to the long-term changes seen in type 2 diabetes. In seasonal animals the responses are acute, physiological and protective. In man, similar responses that would once have conferred survival benefit have become chronic, pathological and harmful in modern life. We hypothesise that type 2 diabetes and cardiovascular disease in man are the result of chronic and inappropriate pinealhypothalamic-adipocyte interactions biologically related to seasonal change.Keywords Adipocyte . Cardiovascular disease . Circadian and circannual rhythm . Clock genes . Hypothalamus . Inflammation . Insulin resistance . Melatonin . Metabolic syndrome . Seasonality . Type 2 diabetes Neel revisitedThe world is currently in the midst of an epidemic of type 2 diabetes, and around 300 million individuals are predicted to develop this disorder by the year 2025 [1]. The close biological relationship between diabetes and cardiovascular disease has focused attention on the common genetic and environmental antecedents of these conditions-the common soil hypothesis [2]-but the pathophysiological basis of these associations remains obscure. In 1962, Neel proposed the thrifty genotype hypothesis, which postulated that insulin overproduction must at one time have had a beneficial effect, in that it would provide 'an important energy conserving mechanism when food intake was irregular and obesity rare' [3]. Although Neel recognised insulin antagonism rather than insulin resistance, he hypothesised that the combination of obesity with increased insulin (or the presence of insulin antagonists) would lead to the development of diabetes. With hindsight, Neel was essentially speculating on the potential metabolic benefits of insulin resistance. The recognition in the last 20 years of an insulin resistance risk cluster [4] indicates that, under certain circumstances, elements of the risk cluster should also be beneficial to the survival of the organism, a response that, by analogy with Neel's original hypothesis, may coincidentally lead to the development of cardiovascular disease in times of plenty. The development of both insulin resistance and inflammation are physiological responses to increasing adiposity that, by definition, should be beneficial to the survival of the organism. The observation that the chronic metabolic milieu associated with type 2 diabetes is harmful raises the possibility that the adipocyte response to fat loading is beneficial when acute and short-lived, as is o...

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“…Recently, common criteria for the clinical diagnosis of metabolic syndrome have been proposed by several major organizations in the Joint Scientific Statement in an attempt to unify all presented criteria [17]. Higher prevalence of the metabolic syndrome has been demonstrated among shift workers [18][19][20][21]. A recent study by De Bacquer et al demonstrates that the risk of development of the metabolic syndrome gradually increases independently of the accumulated years of shift work.…”

Section: Metabolic Syndromementioning

confidence: 99%

Shift work and metabolic syndrome, diabetes mellitus and ischaemic heart disease

Szosland¹

2010

International Journal of Occupational Medicine and Environmental Health

102

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Shift work is affecting 20% to 25% employees and is becoming increasingly prevalent in contemporary life all over Europe and USA. It is associated with several health problems, such as e.g. metabolic syndrome, diabetes mellitus and cardiovascular disease. These diseases are possibly due to an impairment of biological rhythm. The metabolic syndrome is a complex of interrelated risk factors for cardiovascular disease and diabetes. Higher prevalence of the metabolic syndrome has been demonstrated among shift workers. Rotating shift work has an impact on each component of metabolic syndrome. Shift work might also have an impact on metabolic variables, and be a risk factor for type 2 diabetes. Only a few studies reported prevalence of impaired glucose metabolism and diabetes mellitus in relation to shift work. There is rather strong evidence in favour of association between shift work and coronary heart disease and that has been repeatedly demonstrated during over 20 years of research. Recent data increasingly reveal relations between shift work and plasma resistin, ghrelin, leptin and adiponectin.

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Markers of insulin resistance in day and shift workers aged 30-59 years

Abstract: Shift work may be associated with IR syndrome in workers younger than 50 years. These relations may be underestimated mainly by broad definition of shift work and healthy-worker effects.

Cited by 139 publications

References 33 publications

Night Shift Working and Its Impact on Development and Control of Diabetes Mellitus in Workers of Abo Korkas Sugar Factory, El-Minia, Egypt

Night Shift Working and Its Impact on Development and Control of Diabetes Mellitus in Workers of Abo Korkas Sugar Factory, El-Minia, Egypt

Neel revisited: the adipocyte, seasonality and type 2 diabetes

Shift work and metabolic syndrome, diabetes mellitus and ischaemic heart disease

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