Markers of inflammation, Vitamin E and peripheral nervous system function

Iorio, Angelo Di; Cherubini, Antonio; Volpato, Stefano; Sparvieri, Eleonora; Lauretani, Fulvio; Franceschi, Claudio; Senin, Umberto; Abate, G; Paganelli, Roberto; Martín, António; Andrés‐Lacueva, Cristina; Ferrucci, Luigi

doi:10.1016/j.neurobiolaging.2005.07.004

Cited by 44 publications

(40 citation statements)

References 33 publications

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“…Likewise, the peripheral nerve measurements were represented by "Peripheral Nerve Function", and the tapping test and Short Blessed mental test were together represented by "Central Nervous System Function". Age exerted a direct influence on Glucose120, Inflammatory Markers, Peripheral Nerve Function, height and Central Nervous System function [5,6,29,30,32]. When the mediating effect of these variables was accounted for, we found no residual direct effect of age on vibration threshold.…”

Section: Discussionmentioning

confidence: 66%

“…Studies performed on cell culture have demonstrated that the costimulation of Tumor Necrosis Factor -α Receptor1 (TNF-αR1) and Tumor Necrosis Factor -α Receptor2 (TNF-αR2) is a powerful pro-apoptotic stimulus [10]. Further, using data from a large population-based study, Di Iorio et al [6] have recently reported a significant inverse association between peroneal nerve conduction velocity and circulating levels of serum Interleukin-6 Receptor (sIL-6R). Thus, it is reasonable to hypothesize that the mild pro-inflammatory state that is often encountered in older adults may account, at least in part, for the progressive decline of vibrotactile sensitivity.…”

Section: Introductionmentioning

confidence: 99%

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Physiological correlates of age-related decline in vibrotactile sensitivity

Deshpande

Metter

Ling

et al. 2008

Neurobiology of Aging

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The purpose of this study was to describe age-related changes in vibrotactile sensitivity in participants of the Baltimore Longitudinal Study of Aging and to identify factors that are associated with impairment in vibrotactile sensitivity independent of age. Participants (n=523, age:26-95 years) underwent measurements of vibration perception threshold (VPT, 100Hz) under the 2 nd metatarsal head, glucose tolerance, serum inflammatory markers, nerve conduction parameters, movement time and cognition. Univariate and multivariate regression analyses were performed to identify factors that predicted VPT independent of age. Structural equation modeling was used to describe relationships between these variables. VPT was progressively higher with older age. Adjusting for age and height, VPT was similar in men and women and the slope of age-related decline was similar in the two genders. Age, height, peroneal nerve conduction velocity and peroneal nerve amplitude were independent predictors of VPT. Structural equation model demonstrated a direct relationship between peripheral nerve function and VPT. Height and circulating inflammatory markers may

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Section: Discussionmentioning

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Physiological correlates of age-related decline in vibrotactile sensitivity

Deshpande

Metter

Ling

et al. 2008

Neurobiology of Aging

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“…These results are of particular interest in the context of data from InCHIANTI, a population-based study in Italy, which reported associations of higher IL6 and sIL-6R levels with reduced peroneal MNCV (27). Furthermore, an association of higher IL6 with reduced sural and peroneal NAPs was observed in a small study (7).…”

Section: Subclinical Inflammation Dspn and Ncv In Type 2 Diabetesmentioning

confidence: 60%

“…Interestingly, one large population-based study indicated that circulating levels of the soluble IL6 receptor (sIL-6R) may be inversely associated with peroneal motor NCV (MNCV) (27).…”

mentioning

confidence: 99%

Adiponectin, markers of subclinical inflammation and nerve conduction in individuals with recently diagnosed type 1 and type 2 diabetes

Schamarek

Herder

Nowotny

et al. 2016

European Journal of Endocrinology

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Objective: Subclinical inflammation has been implicated in the development of diabetic sensorimotor polyneuropathy (DSPN), but studies using electrophysiological assessment as outcomes are scarce. Therefore, we aimed to investigate associations of biomarkers reflecting different aspects of subclinical inflammation with motor and sensory nerve conduction velocity (NCV) in individuals with diabetes. Design and methods: Motor and sensory NCV was assessed in individuals with recently diagnosed type 2 (nZ352) or type 1 diabetes (nZ161) from the baseline cohort of the observational German Diabetes Study. NCV sum scores were calculated for median, ulnar and peroneal motor as well as median, ulnar and sural sensory nerves. Associations between inflammationrelated biomarkers, DSPN and NCV sum scores were estimated using multiple regression models. Results: In type 2 diabetes, high serum interleukin (IL)-6 was associated with the presence of DSPN and reduced motor NCV. Moreover, higher levels of high-molecular weight (HMW) adiponectin, total adiponectin and their ratio were associated with prevalent DSPN and both diminished motor and sensory NCV, whereas no consistent associations were observed for C-reactive protein, IL18, soluble intercellular adhesion molecule-1 and E-selectin. In type 1 diabetes, only HMW and total adiponectin showed positive associations with motor NCV. Conclusions: Our results point to a link between IL6 and both DSPN and slowed motor NCV in recently diagnosed type 2 diabetes. The reverse associations between adiponectin and NCV in type 1 and type 2 diabetes are intriguing, and further studies should explore whether they may reflect differences in the pathogenesis of DSPN in both diabetes types.

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“…However, the crosssectional design of almost all clinical and epidemiological studies (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17) so far precludes inferences regarding the temporal relationship between inflammation and DSPN, which are essential for any conclusions about causality. One small prospective study assessed plasma levels of soluble adhesion molecules in 28 individuals with diabetes during a 5-year study period and suggested that endothelial activation is associated with nerve conduction slowing (18).…”

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confidence: 99%

Proinflammatory Cytokines Predict the Incidence and Progression of Distal Sensorimotor Polyneuropathy: KORA F4/FF4 Study

et al. 2017

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OBJECTIVEExperimental and epidemiological studies have implicated inflammatory processes in the pathogenesis of distal sensorimotor polyneuropathy (DSPN), but prospective studies are lacking. We hypothesized that biomarkers of inflammation predict the development and progression of DSPN in a population-based cohort. RESEARCH DESIGN AND METHODSThis study was based on participants aged 62-81 years from the Cooperative Health Research in the Region of Augsburg (KORA) F4/FF4 cohort, with a mean follow-up of 6.5 years. The predictive value of systemic levels of eight biomarkers of inflammation was assessed for incident DSPN in 133 incident case subjects and 397 individuals without incident DSPN, and for DSPN progression in 57 patients with prevalent DSPN at both time points. RESULTSHigher hs-CRP, interleukin (IL)-6, tumor necrosis factor (TNF)-a, IL-1 receptor antagonist (IL-1RA), and soluble intercellular adhesion molecule (sICAM-1) and lower adiponectin levels were associated with incident DSPN in age-and sexadjusted analysis; IL-18 and omentin were not. IL-6 (odds ratio 1.31 [95% CI 1.00-1.71]) and TNF-a (odds ratio 1.31 [95% CI 1.03-1.67]) remained associated with incident DSPN after adjusting for known DSPN risk factors. The addition of both cytokines to a clinical risk model improved model fit and reclassification. sICAM-1 and IL-1RA were positively associated with progression of DSPN. CONCLUSIONSSystemic subclinical and vascular inflammation predicted both the onset and progression of DSPN over 6.5 years in an older general population. Thus modulation of inflammatory processes may be relevant to prevent and/or treat diabetic neuropathy.Distal sensorimotor polyneuropathy (DSPN) is the most frequent neurological complication of type 2 diabetes (1). The pathomechanisms leading to the onset and progression of DSPN are not completely understood, which profoundly limits current prevention and treatment. Advanced age and diabetes duration represent the most important known risk factors, but there is increasing evidence that height,

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Markers of inflammation, Vitamin E and peripheral nervous system function

Abstract: Our findings are consistent with the hypothesis that inflammation and inadequate antioxidant defenses are associated with accelerated decline of nerve conduction velocity over the aging process.

Cited by 44 publications

References 33 publications

Physiological correlates of age-related decline in vibrotactile sensitivity

Physiological correlates of age-related decline in vibrotactile sensitivity

Adiponectin, markers of subclinical inflammation and nerve conduction in individuals with recently diagnosed type 1 and type 2 diabetes

Proinflammatory Cytokines Predict the Incidence and Progression of Distal Sensorimotor Polyneuropathy: KORA F4/FF4 Study

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