Markers of inflammation in patients with coronary artery disease are also associated with glycosylated haemoglobin A within the normal range

Abstract

In subjects with known coronary atherosclerosis, low-degree inflammatory activity is not only increased in diabetic patients, but also increased with increasing HbA(1c) in non-diabetic individuals with HbA(1c) within the normal range, i.e., at a pre-diabetic level of glucose metabolism derangement.

Glycosylated Hemoglobin and Mortality in Patients with Nondiabetic Chronic Kidney Disease

“…Impaired glucose tolerance has also been associated with an elevated white cell count, which may be a surrogate for chronic inflammation (29). In a cross-sectional study of patients with coronary atherosclerosis, HbA 1c levels in the high normal range were associated with higher levels of several inflammatory markers, including CRP, erythrocyte sedimentation rate, and white blood cell count (30), although in our study, the relationship of HbA 1c with mortality was independent of CRP. Alternatively, there may be residual confounding from the known clustering of hyperglycemia with CVD risk factors and other components of the metabolic syndrome, including dyslipidemia, obesity, and hypertension.…”

White blood cell count and cardiovascular biomarkers of atherosclerosis

“…The WBC count significantly correlates with HbA 1c in both DM and non-DM 16 patients with known coronary atherosclerosis, and this indicates an early association between glycemia, inflammation and atherosclerosis before DM develops (Gustavsson et al 2004). We also found a correlation between WBC and HbA 1c , which suggests that low-grade chronic inflammatory activity increases in hyperglycemia.…”

Blood glucose lowering by means of lifestyle intervention has different effects on adipokines as compared with insulin treatment in subjects with type 2 diabetes

“…The evidence for an association between glycaemic control and systemic inflammation in subjects with diabetes seems conflicting [32][33][34][35]. The purpose of the present study was to determine the effect on adipokines of lowering blood glucose through lifestyle intervention or through insulin therapy in initially poorly controlled type 2 diabetic patients.…”