Markers of hyperandrogenism in South Asians with polycystic ovary syndrome

Abstract

Background: Many clinical and biochemical criteria are used to assess hyperandrogenism in subjects with polycystic ovary syndrome (PCOS). Standard indicators used to confirm hyperandrogenism are based predominantly on western data. Whilst the phenotype of PCOS has ethnic specific variation, specific cutoffs for hyperandrogenism in South Asians have not been defined.

In depth analysis of the association of FTO SNP (rs9939609) with expression of the classical phenotype of PCOS: a Sri Lankan study

“…Inclusion criteria: Inclusion criteria were adolescent women whose symptoms manifested between 11-19 years of age (WHO), and all 3 diagnostic criteria should be present between 16 -19 years of age [33]. The lower limit of age selection in this study was 15 years, based on the previous study in Sri Lanka and mean age of menarche in Sri Lanka being 13 years and leaving an allowance of two additional years for regularization of menstruation [34].…”

“…Anovular PCOS or amenorrhoea/ oligomenorrhea: Anovular cycles -length of the menstrual cycle is more than 35 days [33]. Amenorrhoea -absence of menstrual periods for six months or more.…”

“…Hyperandrogenism: Clinical evidence of hirsutism was determined by modified Ferriman-Gallwey score (mFG) with the cut off value of ≥ 8 along with serum testosterone levels (T) > 3.5nmol/L [33]. Control sample: Working women of similar ethnic and social background as the affected subjects were recruited for the study.…”

In depth analysis of the association of FTO SNP (rs9939609) with the expression of classical phenotype of PCOS: a Sri Lankan study

“…Adolescent women whose symptoms manifested between 11 and 19 years of age (WHO) with all 3 diagnostic criteria present between 16 and 19 years of age [33] were recruited for this study. The lower age limit for inclusion was 15 years, since the mean age of menarche reported among Sri Lankan girls is 13.54 years (standard deviation, 0.86) and 2 years after menarche was required to exclude the period of menstrual irregularity that usually follows menarche [34].…”

In depth analysis of the association of FTO SNP (rs9939609) with expression of the classical phenotype of PCOS: a Sri Lankan study

“…Inclusion criteria: Inclusion criteria were women whose symptoms manifested from adolescent years (11)(12)(13)(14)(15)(16)(17)(18)(19), with all 3 diagnostic criteria present from 16-19 years of age [33]. The lower limit of age selection was based on the mean age of menarche in Sri Lanka being 13 years and leaving an allowance of two additional years for regularization of menstruation [34].…”