Markers of genetic susceptibility in human environmental hygiene and toxicology: The role of selected CYP, NAT and GST genes

Thier, Ricarda; Brüning, Thomas; Roos, Peter H.; Rihs, Hans‐Peter; Golka, Klaus; Ko, Yon; Bolt, Hermann M.

doi:10.1078/1438-4639-00209

Cited by 161 publications

(88 citation statements)

References 135 publications

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“…For cigarette smoking, polymorphisms in the glutathione S-transferase (GST) gene, which encodes for polycyclic aromatic hydrocarbons involved in the metabolism of tobacco carcinogens, have been shown to affect the risk of lung cancer (48,49). A potential etiologic role of the polymorphism has also been suggested for non-Hodgkin's lymphoma in some studies (50)(51)(52)(53).…”

Section: Discussionmentioning

confidence: 99%

Cigarette Smoking and Risk of Non-Hodgkin's Lymphoma—A Population-Based Case-Control Study

Schöllkopf

Smedby

Hjalgrim

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Epidemiologic evidence of an association between tobacco smoking and non-Hodgkin's lymphoma has been conflicting. This may reflect that non-Hodgkin's lymphoma comprises several distinct disease entities with different etiologies, as some studies have indicated an association between smoking and follicular lymphoma. Objective: To investigate the association between cigarette smoking and non-Hodgkin's lymphoma risk, overall and by subtype. Methods: As part of a nationwide Danish-Swedish population-based case-control study, we interviewed 3,055 incident non-Hodgkin's lymphoma patients and 3,187 population controls. All lymphomas were uniformly classified according to the WHO classification. We used unconditional logistic regression to estimate adjusted odds ratios (OR) and 95% confidence intervals (95% CI) for the association between cigarette smoking and risk of non-Hodgkin's lymphoma.

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Section: Discussionmentioning

confidence: 99%

Cigarette Smoking and Risk of Non-Hodgkin's Lymphoma—A Population-Based Case-Control Study

Schöllkopf

Smedby

Hjalgrim

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…31,32 Case-control studies that test the potential risk of these alleles in Arabs will also contribute in the definition of gene-gene and geneenvironment interactions.…”

Section: Xenobiotic-metabolizing Genes In Arabsmentioning

confidence: 99%

Variable drug metabolism genes in Arab population

Bu¹,

Gutiérrez²,

Al‐Rasheed³

et al. 2004

Pharmacogenomics J

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Cataloging interethnic differences in the distribution of genotypes of drug metabolic genes provides valuable information for profiling the pharmacogenetics of a population. We used PCR analysis to catalog the frequencies of alleles and genotypes for CYP1A1, NAT2, GSTs, MTHFR, MTR (MS) and NQO*1 in Arabs. The frequencies of alleles and/or genotypes for CYP1A1*2A, GSTT1 null, GSTT1 and GSTM1 double null, and GSTP1 A1578G in Arabs were significantly higher than those reported in Caucasians. However, the distribution of NAT2 acetylator phenotypes in both populations was similar. In contrast, the frequencies of MTHFR 677T allele and the combined (677 þ 1298) genotypes for low activity were lower than those reported in Caucasians. Other alleles in Arabs, including CYP1A1 T3801C and GSTP1 A1578G were present in frequencies similar to Africans. The overall profile of variations in metabolism genes in Arabs is thus unique.

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“…The GST family members' ability to catalyze the detoxification of PAHs varies for GSTM1, GSTT1, and GSTP1 [58][59][60]. Both in vivo and in vitro studies have concluded that the GSTM1 null and GSTP1 105Val genotypes decrease the body's PAH detoxification efficiency [58;59], while the GSTT1 null genotype seems to not play an important role in PAH metabolism [31].…”

Section: Discussionmentioning

confidence: 99%

GST genotypes and lung cancer susceptibility in Asian populations with indoor air pollution exposures: A meta-analysis

Hosgood

Berndt

Lan

2007

Mutation Research/Reviews in Mutation Research

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About half of the world's population is exposed to smoke from heating or cooking with coal, wood, or biomass. These exposures, and fumes from cooking oil use, have been associated with increased lung cancer risk. Glutathione S-transferases play an important role in the detoxification of a wide range of human carcinogens in these exposures. Functional polymorphisms have been identified in the GSTM1, GSTT1, and GSTP1 genes, which may alter the risk of lung cancer among individuals exposed to coal, wood and biomass smoke and cooking oil fumes. We performed a meta-analysis of six published studies (912 cases; 1063 controls) from regions in Asia where indoor air pollution makes a substantial contribution to lung cancer risk, and evaluated the association between the GSTM1 null, GSTT1 null, and GSTP1 105Val polymorphisms and lung cancer risk. Using a random effects model, we found that carriers of the GSTM1 null genotype had a borderline significant increased lung cancer risk (odds ratio (OR), 1.31; 95% confidence interval (CI), 0.95-1.79; p=0.100), which was particularly evident in the summary risk estimate for the four studies carried out in regions of Asia that use coal for heating and cooking (OR, 1.64; 95%CI, 1.25-2.14; p=0.0003). The GSTT1 null genotype was also associated with an increased lung cancer risk (OR, 1.49; 95%CI, 1.17-1.89; p=0.001), but no association was observed for the GSTP1 105Val allele. Previous meta-and pooled-analyses suggest at most a small association between the GSTM1 null genotype and lung cancer risk carried out in populations where the vast majority of lung cancer is attributed to tobacco, and where indoor air pollution from domestic heating and cooking is much less than in developing Asian countries. Our results suggest that the GSTM1 null genotype may be associated with a more substantial risk of lung cancer in populations with coal exposure.

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Markers of genetic susceptibility in human environmental hygiene and toxicology: The role of selected CYP, NAT and GST genes

Cited by 161 publications

References 135 publications

Cigarette Smoking and Risk of Non-Hodgkin's Lymphoma—A Population-Based Case-Control Study

Cigarette Smoking and Risk of Non-Hodgkin's Lymphoma—A Population-Based Case-Control Study

Variable drug metabolism genes in Arab population

GST genotypes and lung cancer susceptibility in Asian populations with indoor air pollution exposures: A meta-analysis

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