Markers of collagen metabolism and insulin-like growth factor binding protein-1 in term infants

Hytinantti, Timo; Rutanen, Eeva‐Marja; Turpeinen, M.; Sorva, Ritva; Andersson, Sture

doi:10.1136/fn.83.1.f17

Cited by 12 publications

(4 citation statements)

References 29 publications

(15 reference statements)

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“…This difference may be related to different causes of growth retardation in preterm and full-term infants. In keeping with previous studies (6,8,31,38), our results suggest that both type I collagen synthesis and degradation decrease with increasing gestational age, and the decrease in synthesis is even more rapid. It is of interest that type I collagen is also synthesized in the placenta (40), suggesting that placental collagen turnover may contribute to circulating PINP and ICTP.…”

Section: Discussionsupporting

confidence: 79%

“…Reduced bone mineral content, resulting both from impaired bone modeling and dietary deficiency of minerals (38), is a well-recognized feature of intrauterine growth restriction and prematurity (39). In term infants, however, no difference in cord serum PICP and ICTP has been observed between SGA and AGA groups (7,8). This difference may be related to different causes of growth retardation in preterm and full-term infants.…”

Section: Discussionmentioning

confidence: 80%

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Markers of Type I and Type III Collagen Turnover, Insulin-Like Growth Factors, and Their Binding Proteins in Cord Plasma of Small Premature Infants: Relationships with Fetal Growth, Gestational Age, Preeclampsia, and Antenatal Glucocorticoid Treatment

et al. 2001

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Disorders affecting fetal growth are commonly associated with premature birth. IGFs and their binding proteins (IGFBPs) are potent regulators of fetal growth. In vitro evidence suggests that they regulate collagen turnover. Collagen turnover can be monitored by serum markers of type I collagen synthesis (PINP) and degradation (ICTP) and a marker of type III collagen synthesis (PIIINP). We examined whether these markers in fetal circulation reflect intrauterine growth and maturity, and whether any interrelationship exists between them and fetal IGFs and IGFBPs in preterm infants before 32 wk of gestation. Cord plasma PINP, ICTP, PIIINP, IGF-I, IGF-II, IGFBP-1, and IG-FBP-3 were determined for 98 preterm infants. To express birth weight in units adjusted for gestational age, a birth weight SD score (SDS) was calculated. Negative correlations existed between gestational age and PINP (r ϭ Ϫ0.43; p Ͻ 0.0001), ICTP (r ϭ Ϫ0.34; p ϭ 0.002), and PIIINP (r ϭ Ϫ0.34; p ϭ 0.0001). Positive correlations existed between birth weight SDS and PINP (r ϭ 0.40; p ϭ 0.0002) and ICTP (r ϭ 0.48; p Ͻ 0.0001) but not PIIINP. Moreover, birth weight SDS was positively correlated with IGF-I (r ϭ 0.58; p Ͻ 0.0001) and IGFBP-3 (r ϭ 0.44; p Ͻ 0.0001) and negatively correlated with IGF-II (r ϭ Ϫ0.36; p ϭ 0.003) and IGFBP-1 (r ϭ Ϫ0.50; p Ͻ 0.0001). Gestational age correlated with IGFBP-3 (r ϭ 0.25; p ϭ 0.03). In preeclampsia, IGF-I was lower (p ϭ 0.002) and IGFBP-1 higher (p Ͻ 0.0001), also after adjustment for fetal size. The number of antenatal glucocorticoid treatments was associated with lower ICTP (p ϭ 0.04), higher IGF-I (p ϭ 0.002), lower IGF-II (p ϭ 0.02), lower IGFBP-1 (p ϭ 0.05), and higher IGFBP-3 (p ϭ 0.004), also after adjustment for potential confounders. In multiple regression analysis, the factors significantly associated with PINP (R 2 ϭ 0.47) were gestational age and IGF-I, and those associated with ICTP (R 2 ϭ 0.54) were IGF-I, gestational age, and antenatal glucocorticoid treatment. We conclude that IGF-I may be involved in regulation of type I collagen turnover in the growing fetus. Cord blood PINP and ICTP reflect both fetal growth and maturity and deserve evaluation as potential indicators of postnatal growth velocity in preterm infants, whereas PIIINP reflects fetal maturity. ABSTRACT481

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 80%

Markers of Type I and Type III Collagen Turnover, Insulin-Like Growth Factors, and Their Binding Proteins in Cord Plasma of Small Premature Infants: Relationships with Fetal Growth, Gestational Age, Preeclampsia, and Antenatal Glucocorticoid Treatment

et al. 2001

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“…Data obtained from a large cohort of neonates from a Swiss study (2) show that fetal length and weight plateau at approximately 37 wk of gestation, whereas fetal bone mineralization and ossification increase toward the end of pregnancy. This shift from fetal bone growth to maintenance is also evidenced by inverse correlations between gestational age and bone turnover markers in cord blood (3)(4)(5)(6)(7)(8) or amniotic fluid (9).…”

mentioning

confidence: 99%

Perinatal Bone Turnover in Term Human Neonates and the Influence of Maternal Smoking

et al. 2003

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Bone turnover in neonates appears independently of the comparably low maternal bone turnover, but there is only sparse information on the effect of the in utero environment on fetal bone turnover. Postnatally, the resuming growth velocity and alterations in mineral homeostasis affect neonatal bone turnover. This study evaluated the relationship of bone marker concentrations to maternal and fetal auxological variables as well as maternal smoking and assessed the short-term change in bone markers during the first days of life. Serum markers of bone formation [osteocalcin and bone-specific alkaline phosphatase (BALP)] and bone resorption (C-terminal telopeptide of type I collagen) were measured in cord blood and at discharge (median d 3) in 69 healthy term neonates. Concentrations of BALP were significantly lower in neonates of smokers (n ϭ 16) compared with nonsmokers (n ϭ 53), both at birth (p ϭ 0.013) and at discharge (p ϭ 0.036). Both cord osteocalcin and BALP were negatively related to maternal weight and maternal body mass index. Maternal smoking and pregnancy weight gain were the predictors of cord BALP (r 2 ϭ 0.24; p Ͻ 0.001), whereas the mode of delivery best predicted cord C-terminal telopeptide of type I collagen levels (r 2 ϭ 0.19; p Ͻ 0.001). C-terminal telopeptide of type I collagen and osteocalcin increased significantly (p Ͻ 0.001) from birth to discharge, whereas BALP levels did not change significantly during the same period. Our results suggest that maternal smoking during pregnancy and maternal obesity may have a negative impact on fetal bone formation. The significant increase of osteocalcin and C-terminal telopeptide of type I collagen may result either from an increase in bone turnover or altered renal clearance. Abbreviations BALP, bone-specific alkaline phosphatase CTX, cross-linked carboxy-terminal telopeptide of type I collagen (crossLaps) OC, osteocalcin ALP, alkaline phosphatase AGA, appropriate for gestational age SGA, small for gestational age BMI, body mass index BMC, bone mineral content CV, coefficient of variation PGH, placental GH Linear growth in the fetus is high during the second trimester of pregnancy, but drops sharply after the 30th wk of gestation (1). Data obtained from a large cohort of neonates from a Swiss study (2) show that fetal length and weight plateau at approximately 37 wk of gestation, whereas fetal bone mineralization and ossification increase toward the end of pregnancy. This shift from fetal bone growth to maintenance is also evidenced by inverse correlations between gestational age and bone turnover markers in cord blood (3-8) or amniotic fluid (9).Postnatally, the first 6 to 12 d represent a transitional growth period. This is characterized by large individual variations (2) in body weight and hydration state that complicate the assessment of the postnatal growth pattern. Because of the large measurement errors during this period, reliable growth data are sparse and inconsistent for the first days of life. However, along with the postnatal resumption in gr...

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“…Vanhaesebrouck et al [10] found that SGA infants have lower concentrations of type III collagen than AGA infants at birth. Hytinantti et al [11] showed that there was a negative correlation between the metabolism of type I and III collagen and gestational age. In the present study, we found positive correlations between cord blood prolidase activity and both birth weight and gestational age in keeping with Namiduru et al [12] who showed that cord blood serum prolidase activity was positively correlated with birth weight.…”

Section: Discussionmentioning

confidence: 99%

Cord Blood Prolidase Activity Correlates with Gestational Age and Birth Weight

Üstündağ

Akarsu²,

Kurt³

et al. 2008

Neonatology

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Background: Prolidase, a specific iminopeptidase involved in collagen turnover, is especially active in growing tissues. Objectives: To investigate the relationship between cord blood prolidase activity and both birth weight and gestational age. Methods: Cord blood was collected consecutively from 50 healthy newborns (35 term, 15 preterm). Prolidase activity was measured in the samples using standard methods. Results: Themean ± SD cord blood prolidase activity was 41.4 ± 6.9 U/l in term infants and 35.2 ± 8.0 U/l in preterm infants and these were significantly different (p < 0.01). There were positive correlations between cord blood prolidase and both birth weight (r = 0.533, p < 0.01) and gestational age (r = 0.806, p < 0.01). Conclusion: Cord blood prolidase activity may be a good indicator of fetal maturation and gestational age.

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Markers of collagen metabolism and insulin-like growth factor binding protein-1 in term infants

Abstract: Conclusions-In the term fetus, collagen metabolism is primarily dependent on maturity and not on intrauterine growth status, whereas IGFBP-1 reflects intrauterine growth independently of maturity. (Arch Dis Child Fetal Neonatal Ed 2000;83:F17-F20)

Cited by 12 publications

References 29 publications

Markers of Type I and Type III Collagen Turnover, Insulin-Like Growth Factors, and Their Binding Proteins in Cord Plasma of Small Premature Infants: Relationships with Fetal Growth, Gestational Age, Preeclampsia, and Antenatal Glucocorticoid Treatment

Markers of Type I and Type III Collagen Turnover, Insulin-Like Growth Factors, and Their Binding Proteins in Cord Plasma of Small Premature Infants: Relationships with Fetal Growth, Gestational Age, Preeclampsia, and Antenatal Glucocorticoid Treatment

Perinatal Bone Turnover in Term Human Neonates and the Influence of Maternal Smoking

Cord Blood Prolidase Activity Correlates with Gestational Age and Birth Weight

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