Markers for bacterial infection in children with fever without source

Abstract

The study data demonstrate that CRP, PCT, WBC and ANC had almost similar diagnostic properties and were superior to clinical evaluation in predicting SBI in children aged 1 month to 3 years.

Neutrophils: Neglected Players in Viral Diseases

“…Neutrophils have been used as diagnostic tools in clinical settings: neutrophil absolute count (Wile et al, 2001;Pratt and Attia, 2007;Bressan et al, 2010;Manzano et al, 2011), enumeration of band neutrophils (band count) (Seebach et al, 1997;Al-Gwaiz and Babay, 2007), and the expression levels of neutrophil surface proteins (Nupponen et Rudensky et al, 2008;Dilli et al, 2010;Genel et al, 2012;Jia et al, 2013) to predict bacterial infections and severity outcomes. Due to the increasing evidence of neutrophils being involved in mediating viral diseases (Tumpey et al, 2005;Duffy et al, 2012), it is now possible to develop new diagnostic tools capable of distinguishing between viral and bacterial diseases.…”

The Outcome of Blood Cultures in Febrile Children Presenting at theEmergency Department

“…Fever is an important clinical sign because of the association of an underlying infection, although most infections are viral. However, a small group of these children may have a serious bacterial infection as the cause of the fever [2,3,[5][6][7]. One of the greatest challenges to physicians caring for febrile children in the PED is therefore the risk of an occult bacteremia (OB) [8,9].…”

“…The clinical management of children older than 3 months of age, who present in the PED with fever, is still controversial [10,12]. There is great heterogeneity in the evaluation and the management practices of this group of patients, including the need for a complete blood count (CBC), measurement of C-reactive protein (CRP) and blood culture (BC) [2][3][4]6,7,13]. BC remains still the gold standard approach to determine the presence or absence of pathogens in a child with a suspected serious bacterial infection or fever of unknown origin [10,[14][15][16][17][18].…”

Diagnostic Value of Determining the Level of Procalcitonin in the Practice of an Infectious Disease Specialist

“…[3], показал, что для детей с ЛБОИ при диагностике ТБИ повышение кон-центрации ПКТ выше 0,5 нг/мл имеет достаточно высо-кую чувствительность (83%) и невысокую специфичность (69%). Лишь в немногих источниках можно найти данные о значимом повышении ПКТ более 2 нг/мл как предикто-ра ТБИ у пациентов с ЛБОИ [5,19]. Так, было показано, что превышение этого показателя у лихорадящих детей различного возраста позволяет дифференцировать ТБИ от ее отсутствия [20].…”