"Marker of self" CD47: from erythrocyte to drug delivery

Engineered Cell Membrane-Derived Nanocarriers: The Enhanced Delivery System for Therapeutic Applications

“…In addition, mature erythrocytes have no nucleus or complex organelles, making it easy to obtain a pure cell membrane ( Wibroe et al, 2017 ). Moreover, the erythrocyte membrane itself has a multitude of natural “self markers” such as CD47 proteins, glycans and acidic silyl molecules which enable its encapsulated nanoparticles to evade immunogenic clearance and provide extending circulation times for the nanoparticles ( Oldenborg et al, 2000 ; Dahl et al, 2002 ; Ke et al, 2022 ). Therefore, the erythrocyte membrane is an ideal material for nanoparticle surface modification.…”

“…In tumors, numerous cancer cells display homotypic targeting through surface-specific antigens with homophilic adhesion domains ( Fang et al, 2014 ). Therefore, the use of cancer cell membrane-coated nanoparticles can perfectly replicate various surface antigens from cancer cell membranes to gain the ability to escape immune clearance and homologous targeting thus being considered as promising cancer therapies ( Oldenborg et al, 2000 ; Dahl et al, 2002 ).…”

“…Proteins and carbohydrates are essential for the interfacial interaction, particularly for signal recognition. Moreover, the cell membrane carries many natural “self markers” such as CD47, CD44 proteins and glycans, which enable the nanoparticles to escape from immunogenic clearance ( Oldenborg et al, 2000 ; Dahl et al, 2002 ). Notably, most cancer cells display homologous targeting ability due to the presence of specific membrane proteins such as N-cadherin, galectin-3, and epithelial cell adhesion molecules (EpCAM) ( Fang et al, 2014 ).…”