Marker Chromosome Analysis of Tetraparental AKR↔CBA-T6 Mouse Chimaeras

Ford, C. E.; Evans, E. P.; Burtenshaw, M. D.; CLEGG, HILARY M.; Barnes, R. D.; Tuffrey, Maureen

doi:10.1111/j.1432-0436.1974.tb00367.x

Cited by 42 publications

(25 citation statements)

References 15 publications

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“…Whereas large amounts of virus were seen in the predominantly albino (AKR) mice, very little was present in those chimaeras which were predominantly agouti (CBA) (Wills et al, 1975;Barnes et al, 1976b). This was remarkable because cytogenetic analysis had shown that the vast majority of the dividing cells examined in each chimaera had the AKR karyotype Ford et al, 1974). How this occurred is uncertain.…”

Section: Methodsmentioning

confidence: 96%

The innate resistance of CBA mice to endogenous murine leukaemia virus infection

Barnes¹,

Tuffrey²,

Willis³

et al. 1976

Br J Cancer

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The incidence of lymphomata in CBA mice is low and furthermore is unaltered by transplantation at the early blastocyst stage and being born from the lymphoma-prone AKR. The number of C-type murine leukaemia virus particles in CBA derived in this manner and milk-fostered by AKR mice in no way differs from normal CBA. The results suggest that the oncogenic Gross virus does not pass through either the transplacental or transmammary routes, or alternatively that viral replication in the CBA was in some way inhibited. Both possibilities have still to be distinguished. Images Fig. 1 Fig. 2

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Section: Methodsmentioning

confidence: 96%

The innate resistance of CBA mice to endogenous murine leukaemia virus infection

Barnes¹,

Tuffrey²,

Willis³

et al. 1976

Br J Cancer

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“…Thus, it would be likely that the particular strains of mice used in the allophenic combinations would determine the degree of concordance of the various cell populations in the adult mice. This conclusion would explain the data reported and those of Gornish (Gornish et al, 1972) and Ford (Ford et al, 1975) (see Introduction). The situation with respect to spleen-thymus discordance is much simpler, since the error in these two types of determination is always < 10%.…”

Section: B Composition Of the Immune System Of Allophenic Micesupporting

confidence: 74%

Chimeric drift and immunological tolerance in allophenic mice

Stephens

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“…This developmental switch, which has occurred by 13.5 dpc, is dependent on the sex of the somatic cells in the gonad, rather than the chromosomal sex of the PGCs: XY PGCs can develop as oocytes in female embryos, and XX PGCs can develop as prospermatogonia in male embryos (Ford et al, 1975;Palmer & Burgoyne, 1991 a). Wh en germ cells migrate into ectopie sites su ch as the ad renal gland, they will develop as oocytes even in male embryos, entering meiosis with apparently normal timing (Zamboni & Upadhyay, 1983).…”

Section: B Differentiation Of Pgcs and Somatic Cellsmentioning

confidence: 99%