Marker Band in One Chromosome 14 from Burkitt Lymphomas

MicroRNAs and genomic instability

“…For example, the original experiments of Nowell and Hungerford [2] connected the Philadelphia chromosome (Ph'), generated by a T(9:22) translocation with chronic myelogenous leukemia (CML) and subsequent molecular analysis of the breakpoints showed that this results in the formation of the BCR-ABL fusion oncogene [3]. Similar cytogenetic studies in Burkitt's Lymphoma identified T(8:14) as a major chromosomal translocation event [4,5]. Follow up molecular studies showed that as a result of this translocation the proto-oncogene c-MYC is placed adjacent to the immunoglogulin heavy chain gene leading to cell transformation [6].…”

Surface phenotyping, histology and the nature of non-Hodgkin lymphoma in 157 patients

“…In this sense, nonHodgkin lymphoma (NHL) can be regarded as an abnormal immune response equivalent to a selective immune deficiency, limited to one clone of cells and evoked by a single antigen. Evidence for this statement is based on the close similarity between the chromosomal defect in ataxia telangiectasia and defects described in various forms of lymphoma (Louie & Schwartz, 1978;McCaw et al, 1975;Fukahara et al, 1976;Manolov & Manolova, 1972) and on the antibody activity of monoclonal immunoglobulins isolated from patients with lymphoma (Salmon & Seligmann, 1974).…”

Burkitt-type lymphoma in France among non-Hodgkin malignant lymphomas in Caucasian children

“…BL is also a cytogenetic entity: in 4 of our cases, the tumour cells were studied by banding techniques, and 3 translocations of (8;14) and one variant translocation, t (8;22), were found (Bertrand et al, 1981). The 8; 14 translocation, initially reported in African cases as a 14q + (Manolov & Manolova, 1972), has been found in most non-endemic BLs (Zech et al, 1976). Two variant translocations, t (2 ;8) and t (8 ;22), were then described in both endemic and non-endemic BL (Bernheim et al, 1981).…”