Marked lymphovascular invasion, progesterone receptor negativity, and high Ki67 labeling index predict poor outcome in breast cancer patients treated with endocrine therapy alone

Kurebayashi, Junichi; Kanomata, Naoki; Shimo, Toshiro; Yamashita, Tetsumasa; Aogi, Kenjiro; Nishimura, Rieko; Shimizu, Chikako; Tsuda, Hitoshi; Moriya, Takuya; Sonoo, Hiroshi

doi:10.1007/s12282-012-0380-z

Cited by 16 publications

(12 citation statements)

References 28 publications

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“…23 However, these findings are not without controversy, as several groups found that ALDH1 expression did not correlate with clinical parameters and was not an independent prognostic factor in breast cancer. 10,33 In our cohort, we observed ALDH1 expression in both the DCIS epithelial compartment and the local stroma environment. ALDH1 protein levels in either compartment were not statistically associated DCIS recurrence or invasive progression, although ALDH1 expression with the DCIS lesion trended toward increased risk.…”

mentioning

confidence: 67%

EZH2 and ALDH1 expression in ductal carcinoma in situ: Complex association with recurrence and progression to invasive breast cancer

Knudsen¹,

Dervishaj

Kleer

et al. 2013

Cell Cycle

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mentioning

confidence: 67%

EZH2 and ALDH1 expression in ductal carcinoma in situ: Complex association with recurrence and progression to invasive breast cancer

Knudsen¹,

Dervishaj

Kleer

et al. 2013

Cell Cycle

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“…1 More than half of newly diagnosed Japanese breast cancer patients are estimated to have node-negative, invasive disease, resulting in local or distant recurrence within 10 years of the diagnosis in 10% to 15% of these patients. 2,3 Therefore, it has been important to establish criteria for identifying the high-risk patient groups for whom adjuvant chemotherapy might be beneficial.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Significance of Progesterone Receptor Expression in Estrogen-Receptor Positive, HER2-Negative, Node-Negative Invasive Breast Cancer With a Low Ki-67 Labeling Index

Ono¹,

Tsuda

Yoshida

et al. 2017

Clinical Breast Cancer

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Section: Discussionmentioning

confidence: 99%

“…The Ki-67 protein is an (IHC) marker of cell proliferation associated nuclear antigen which is expressed in dividing cells during cell cycle (G1, S, G2 and M) but not on (G0) [6,7]. The labeling index of Ki-67 has a direct correlation with the degree of cells proliferation, and has prognostic value in several types of cancer [8][9][10][11][12]. The Ki-67 is a commonly used proliferation marker in breast cancer.…”

Section: Introductionmentioning

confidence: 99%

“…Tumor cells proliferation is an important biological parameter that reflects disease behavior, which might also predicts for disease prognosis. The nuclear protein Ki-67 is a proliferative marker and widely used prognostic indicator in several cancer diagnosis, including breast cancer, bladder cancer, gastrointestinal neuroendocrine tumor, oral cancer, lung cancer, astrocytoma, and pituitary adenoma [8][9][10][11][12]23,24].In endometrial cancers, Ki-67 in addition to other biomarkers was found to be useful marker to distinguish benign proliferative conditions from cancer precursors and low grade endometrioid adenocarcinomas (16,25). In a study on 270 endometrial samples Ki-67 expression was found to be higher in samples with high-grade endometrioid carcinomas vs normal endometrial samples [26].…”

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confidence: 99%

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Can Ki-67 Predict Pelvic Node Status in Endometrial Adenocarcinoma?

2016

J Cancer Sci

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Background: The Ki-67 marker is a nuclear protein that has a direct correlation with the degree of cells proliferation that often expressed in human neoplasm.Objective: To evaluate utilization of Ki-67 expression as predictor for pathological nodal positivity in endometrial endometrioid adenocarcinoma.Design: A retrospective case control study. Settings: Tertiary cancer center. Materials and methods:We evaluated 12 histopathological slides for patients with endometrioid adenocarcinoma of the uterus for percentage of expression of Ki-67. We defined high expression as Ki-67 stained > 50% of tumor cells. Main outcome measures:The correlation of Ki-67 high expression rates and pelvic node positivity in endometrioid adenocarcinoma.Results: Our sample mean age at diagnosis is (58.25 years) and median age is (57 years). The rate of high expression of Ki-67 in tumor cells among cases with positive lymph nodes vs controls were significantly higher (83%) vs (17%), with (p-value = 0.04). There were no significant differences between the mean age in cases and controls (59.8 vs 56.67) with (p = 0.67), tumor grade (p = 0.3), myometrium invasion (p = 0.1), cervical stromal invasion (p = 0.2), lymphovascular invasion (p = 0.2). On multivariate analysis a high expression of Ki-67 continued to be independent predictor for lymph node positivity (p = 0.02). Conclusions:This finding suggests that a high expression of Ki-67 plays an important role as predictor for lymph node positive in endometrioid adenocarcinoma. The level of expression of Ki-67 can be utilized for preoperative or postoperative risk assessment to predict for lymph node metastasis for cases with borderline indications for postoperative pelvic irradiation. Further prospective larger study is needed to validate this preliminary data. Page -02 ISSN: 2377-9292 adenocarcinoma of the uterus. The study was conducted in tertiary cancer center at King Abdullah Medical City. The protocol was reviewed and approved by institutional review board. Population was identified via search of hospital Electronic Medical Records between June of 2014 and June of 2016. We identified 48 cases with endometrial adenocarcinoma, then we identified 6 cases with pelvic node positive disease with no distance metastasis and we identified 6 matched controls of node negative. We match the cases and control for age and other clinicopathological characteristics including: tumor grade, lymphovascular space invasion, myometrial invasion and cervix invasion. The Immunohistochemical stain of Ki-67 was carried on unstained pathological slides taken from formalin-fixed, paraffinembedded tissues by standard automated immunohistochemistry on Ventana machine.We defined high expression as Ki-67 staining > 50% of tumor cells. All readings of the percentage of Ki-67 were carried out by one pathologist to overcome observers' variation (Figures 1 and 2). Statistical analysisCollected data was transferred and analyzed by using SPSS ver. 24 (SPSS Inc.). The correlation of high expression of Ki-67 with pelv...

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Marked lymphovascular invasion, progesterone receptor negativity, and high Ki67 labeling index predict poor outcome in breast cancer patients treated with endocrine therapy alone

Cited by 16 publications

References 28 publications

EZH2 and ALDH1 expression in ductal carcinoma in situ: Complex association with recurrence and progression to invasive breast cancer

EZH2 and ALDH1 expression in ductal carcinoma in situ: Complex association with recurrence and progression to invasive breast cancer

Prognostic Significance of Progesterone Receptor Expression in Estrogen-Receptor Positive, HER2-Negative, Node-Negative Invasive Breast Cancer With a Low Ki-67 Labeling Index

Can Ki-67 Predict Pelvic Node Status in Endometrial Adenocarcinoma?

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