2005
DOI: 10.1111/j.1540-8159.2005.00089.x
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Marked Improvement in Left Ventricular Function and Significant Reverse Left Ventricular Remodeling within 3 Months of Cardiac Resynchronization Therapy in Patients with Dilated Cardiomyopathy

Abstract: We monitored reverse left ventricular (LV) remodeling and LV function during the first 6 months of cardiac resynchronization therapy (CRT) in 34 patients (mean age = 55.3 +/- 13.6 years, 28 men) with dilated cardiomyopathy (DCM), left bundle branch block, in stable New York Heart Association class III, and on fixed drug regimen who underwent implantation of CRT systems with or without cardioverter defibrillator back-up. QRS-complex duration was reduced from 169.69 +/- 19.6 ms (SD) to 144.1 +/- 23.4 ms during C… Show more

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Cited by 6 publications
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“…Two other patients did not present QRS narrowing, but both had clinical and echocardiographic improvements, albeit mild. Ventricular remodeling may occur even early in resynchronized patients (3 months after implantation) 20 , and is fundamental as a predictor of sustained clinical improvement 21 . Several clinical variables attempted to identify subgroups with possible favorable responses to resynchronization, however the findings were not uniform 22,23 .…”
Section: Discussionmentioning
confidence: 99%
“…Two other patients did not present QRS narrowing, but both had clinical and echocardiographic improvements, albeit mild. Ventricular remodeling may occur even early in resynchronized patients (3 months after implantation) 20 , and is fundamental as a predictor of sustained clinical improvement 21 . Several clinical variables attempted to identify subgroups with possible favorable responses to resynchronization, however the findings were not uniform 22,23 .…”
Section: Discussionmentioning
confidence: 99%
“…In einer Vielzahl von kleineren Studien und im CRT-Arm der MIRACLE-Studie konnte nun bereits gezeigt werden, dass CRT zu einem «reversen linksventrikulären remodeling» mit Verkleinerung der enddiastolischen und endsystolischen Volumina und Diameter und damit auch zu einer Reduktion der Mitralinsuffizienz führt [9][10][11][12][13]. Bei näherer Betrachtung der Überlebenskurven aus der COMPANION-Studie wird ersichtlich, dass sich der Vorteil der CRT-Gruppe gegenüber der medikamentös therapierten Gruppe erst nach ungefähr 8 Monaten herauskristallisiert.…”
Section: Days After Randomizationunclassified