Marked Hyperthermia as a Manifestation of Hypoglycemia in Long-standing Diabetes Mellitus

Chochinov, Ronald H.; Daughaday, William H.

doi:10.2337/diab.24.9.859

Cited by 7 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thereafter, 1-2 hr following the tolbutamide load, during the period of profound hypoglycaemia, 20-25 % of the chickens were lying in their cages exhibiting muscular flacidity, appearing indifferent to external environment, and 7-10% suffered several convulsions. The symptoms of panting and the fact that, in man, hypoglycaemia is sometimes associated with hyperthermia (Chochinov and Daughaday 1975) suggested that the chicken's body temperature might increase during tolbutamide-induced hypoglycaemia. In fact, as shown in Table 1, the body temperature of chickens was not modified after tolbutamide.…”

Section: Effect Of Acute Ingestion Of Tolbutamide On Plasma Glucose mentioning

confidence: 99%

Effects of Acute and Chronic Ingestion of Tolbutamide in the Chicken

Simon¹

1980

Horm Metab Res

View full text Add to dashboard Cite

The effects of acute and chronic ingestion of tolbutamide were studied in the growing chicken. After an oral load of 100 or 25 mg tolbutamide/kg b.w., plasma insulin levels increased in a dose-dependent manner but to relatively low levels for about 10 min, while 10-20 min following tolbutamide, plasma glucose levels were markedly decreased and remained so for 2--5 hr. After 100 mg tolbutamide/kg, the profound hypoglycaemia which developed, was generally accompanied by symptoms resembling an hypoglycaemic coma: panting, muscular flacidity and convulsion. Body temperature and plasma calcium levels were not changed during and after tolbutamide-induced insulin release. In the chicken, tolbutamide response is therefore characterized by a fugitive insulin release and a profound and prolonged hypoglycaemia which suggest that the action of insulin is potentiated by other factors. Chronic ingestion of tolbutamide in the diet transiently (for one week) increased the live body weight of a dose of 400 mg tolbutamide/kg of diet. Long term (5 weeks) fasting plasma glucose levels were unchanged and fasting plasma insulin levels were decreased in the chronic tolbutamide treated chickens.

show abstract

Section: Effect Of Acute Ingestion Of Tolbutamide On Plasma Glucose mentioning

confidence: 99%

Effects of Acute and Chronic Ingestion of Tolbutamide in the Chicken

Simon¹

1980

Horm Metab Res

View full text Add to dashboard Cite

show abstract

“…The unimpaired awareness of hypoglycaemia in all ten affected diabetics would suggest that the central gluco-receptors themselves are intact. Other autonomic disturbances which have been described in diabetes -such as nocturnal sweating [12], autonomic overactivity [13] and pyrexia of hypoglycaemia [14] could be the result of central autonomic nervous system dysfunction. Alternately, a defect in the function of a neurotransmitter common to the central and peripheral nervous system could explain our findings.…”

Section: Resultsmentioning

confidence: 99%

Hormonal responses to insulin infusion in diabetes mellitus

et al. 1979

View full text Add to dashboard Cite

“…The odds of hypoglycemia among preterm neonates with hypothermia were 4.5 times higher as compared to preterm neonates without hypothermia. When a baby gets cold, he or she uses up more glycogen to keep warm, and then they must use their glucose stores to keep warm, which causes blood sugar to drop and the baby to become hypothermic, as well as hypoglycemic 32,33 . As a result, preventing and managing hypothermia through warm chains and skin-to-skin care is critical to avoid hypoglycemia and its associated complications 23,34 .…”

Section: Discussionmentioning

confidence: 99%

Maximizing the detection rate of hypoglycemia among preterm neonates admitted in Neonatal intensive care unit in Ethiopia, 2021

Chanie

Shiferaw

Feleke

et al. 2023

Sci Rep

View full text Add to dashboard Cite

The burden of hypoglycemia is high in resource limited countries, such as Ethiopia. However, there are no sufficient studies conducted in Ethiopia in general and in the study setting in particular in the previous era. Hence, this study aims to assess the proportion of hypoglycemia and associated factors among preterm neonates admitted to the neonatal intensive care unit at Debre Tabor Comprehensive Specialized Hospital, Ethiopia, in 2021. A hospital-based cross-sectional study was conducted from October 1 to December 30, 2021, at Debre Tabor Comprehensive Specialized Hospital in the neonatal intensive care unit ward. The data was entered in Epi-info 7 and exported to STATA version 14. A binary and multivariable logistic regression was computed at 95% confidence interval (CI). During bivariable analysis, variables having a p-value of less than 0.25 were chosen for multivariable logistic regression analysis, and variables having a p-value of less than 0.05 in multivariable analysis, were significant associations with the dependent variable. The study included 267 preterm neonates, and 23.59% (95% CI 18.9–29.1) were develop hypoglycemia. Moreover, 49 (18.35%) preterm neonates died during the study period. In this study, preterm neonates with hypothermia [Adjusted Odds Ratio (AOR = 4.5; 95 CI 3.4, 7.2)], birth asphyxia (AOR = 5.1; 95 CI 3.9, 27.1), seizure (AOR = 4.7; 95 CI 2.8, 17.8), and also preterm neonates born from diabetic mothers (AOR = 6.7; 95 CI 3.3, 27.2) were significantly associated with the occurrence of hypoglycemia in the neonatal intensive care. The proportion of hypoglycemia and associated factors among preterm neonates admitted to the neonatal intensive care unit at Debre Tabor Comprehensive Specialized Hospital was found to be high. The associated factors for the occurrence of hypoglycemia were discovered to be neonates with hypothermia, birth asphyxia, seizure, and neonates born with a diabetes mother. Thus, recognizing and treating the above associated factors is essential to preventing, and controlling hypoglycemia.

show abstract

Marked Hyperthermia as a Manifestation of Hypoglycemia in Long-standing Diabetes Mellitus

Cited by 7 publications

References 0 publications

Effects of Acute and Chronic Ingestion of Tolbutamide in the Chicken

Effects of Acute and Chronic Ingestion of Tolbutamide in the Chicken

Hormonal responses to insulin infusion in diabetes mellitus

Maximizing the detection rate of hypoglycemia among preterm neonates admitted in Neonatal intensive care unit in Ethiopia, 2021

Contact Info

Product

Resources

About