Marked Enlargement of the Liver and Transient Ascites Associated with the Treatment of Diabetic Acidosis

Bronstein, Howard D.; Kantrowitz, Paul A.; Schaffner, Fenton

doi:10.1056/nejm195912242612603

Cited by 38 publications

(12 citation statements)

References 17 publications

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“…The enzyme elevation is thought to reflect hepatocyte injury causing enzyme leakage rather than actual cell death. We believe that a similar mechanism of enzyme leakage resulting from marked accumulation of hepatocellular glycogen causes the transient elevations in liver transaminases after insulin loading in the treatment of diabetic ketoacidosis (9,10). In GH, liver transaminases, even when markedly elevated, typically return to normal with adequate control of blood sugar levels (3,4,(11)(12)(13).…”

Section: Discussionmentioning

confidence: 94%

Complete Reversal of Glycogen Hepatopathy With Pancreas Transplantation: Two Cases

et al. 2007

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Glycogen hepatopathy is the pathological overloading of hepatocytes with glycogen that is associated with poorly controlled diabetes mellitus. Clinically, it presents with abdominal discomfort, tender hepatomegaly and elevated transaminases. In this report, we describe our experience with two cases of type I diabetes mellitus and glycogen hepatopathy. The patients underwent isolated pancreas transplantation, following which, we have been able to demonstrate complete histological resolution of glycogen hepatopathy associated with control of glucose metabolism.

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Section: Discussionmentioning

confidence: 94%

Complete Reversal of Glycogen Hepatopathy With Pancreas Transplantation: Two Cases

et al. 2007

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“…Hepatomegaly is sometimes detected in diabetic patients with poor glycemic control (1)(2)(3). In this report, we present a case of glycogen storage hepatomegaly, caused by a massive dose of long-acting insulin and large doses of glucose, in a type-2 diabetic patient.…”

Section: Introductionmentioning

confidence: 90%

“…P l a i n a b d o mi n a l CT s c a n o n h o s p i t a l i z a t i o n d a y 3 . T h e l i v e r wa s g r o s s l y e n l a r g e d , wi t h v o l u me o f 1 3 6 6 c m 3 .…”

Section: Introductionunclassified

Rapid Onset of Glycogen Storage Hepatomegaly in a Type-2 Diabetic Patient after a Massive Dose of Long-acting Insulin and Large Doses of Glucose

et al. 2006

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“…Despite some previously mentioned studies showing that glycogen storage is decreased in persons with type 1 diabetes, there are numerous case reports of excessive glycogen storage in type 1 diabetes patients [103][104][105][106][107][108][109][110][111][112], some of the cases also had hepatic steatosis. The diabetes of all the patients that were examined due to palpable hepatomegaly was poorly controlled.…”

Section: Cases Of Excessive Glycogen Storage In Type 1 Diabetesmentioning

confidence: 99%

Hepatic Steatosis in Type 1 Diabetes

Regnell

Lernmark

2011

Rev Diabet Stud

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■ AbstractIslet autoimmunity in type 1 diabetes results in the loss of the pancreatic β-cells. The consequences of insulin deficiency in the portal vein for liver fat are poorly understood. Under normal conditions, the portal vein provides 75% of the liver blood supply. Recent studies suggest that non-alcoholic fatty liver disease (NAFLD) may be more common in type 1 diabetes than previously thought, and may serve as an independent risk marker for some chronic diabetic complications. The pathogenesis of NAFLD remains obscure, but it has been hypothesized that hepatic fat accumulation in type 1 diabetes may be due to lipoprotein abnormalities, hyperglycemia-induced activation of the transcription factors carbohydrate response element-binding protein (ChREBP) and sterol regulatory element-binding protein 1c (SREBP-1c), upregulation of glucose transporter 2 (GLUT2) with subsequent intrahepatic fat synthesis, or a combination of these mechanisms. Novel approaches to non-invasive determinations of liver fat may clarify the consequences for liver metabolism when the pancreas has ceased producing insulin. This article aims to review the factors potentially contributing to hepatic steatosis in type 1 diabetes, and to assess the feasibility of using liver fat as a prognostic and/or diagnostic marker for the disease. It provides a background and a case for possible future studies in the field.

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Marked Enlargement of the Liver and Transient Ascites Associated with the Treatment of Diabetic Acidosis

Cited by 38 publications

References 17 publications

Complete Reversal of Glycogen Hepatopathy With Pancreas Transplantation: Two Cases

Complete Reversal of Glycogen Hepatopathy With Pancreas Transplantation: Two Cases

Rapid Onset of Glycogen Storage Hepatomegaly in a Type-2 Diabetic Patient after a Massive Dose of Long-acting Insulin and Large Doses of Glucose

Hepatic Steatosis in Type 1 Diabetes

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