Marked Elevation of Serum Transaminase Activity Associated with Extrahepatic Biliary Tract Disease

Antidiabetic effect ofStreblus asperin streptozotocin-induced diabetic rats

“…Therefore, an increase in the activities of GOT, GPT and ALP in plasma may be mainly due to the leakage of these enzymes from the liver cytosol into the blood stream (Fortson et al, 1985), which gives an indication of the hepatotoxic effect of STZ. On the other hand, treatment of the diabetic rats with α-amyrin acetate caused the reduction in the activity of these enzymes in plasma compared to the mean values of diabetic group and consequently, may alleviate liver damage caused by STZ-induced diabetes.…”

Hypoglycaemic effect ofMelothria heterophyllain streptozotocin-induced diabetic rats

“…Therefore, increase in the activities of GOT, GPT and ALP in plasma may be mainly due to the leakage of these enzymes from the liver cytosol into the blood stream (Fortson et al, 1985), which gives an indication on the hepatotoxic effect of STZ. On the other hand, independent treatment of the diabetic rats with GA and rutin caused the reduction in the activity of these enzymes in plasma compared to the mean values of the diabetic group and consequently, may alleviate liver damage caused by STZ-induced diabetes.…”

Liver enzyme alteration: a guide for clinicians

“…Finally, as many as 25% of the patients with AST levels greater than 10 times the upper reference limit may have acute extrahepatic biliary tract obstruction, which can be heralded by a peak in aminotransferase levels (> 50 times the upper reference value in 1%-2% of patients) that rapidly subsides once the obstruction has been removed. 5,43,44,45 The patient's history, presence of symptoms such as biliary pain and the ultrasound evidence of dilated bile ducts can provide a definitive diagnosis.…”