Marked elevation of circulating CD19 + CD38 hi CD24 hi transitional B cells give protection against neonatal sepsis

Li, Sitao; Ma, Fei; Hu, Hao; Wang, Desheng; Gao, Yu; Zhou, Jiaqi; Li, Fēi; Lin, Hung‐Chih; Xiao, Xueshan; Zeng, Qing

doi:10.1016/j.pedneo.2017.10.005

Cited by 20 publications

(21 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…55 Immediately after delivery, the neonatal immunity must modulate the transition from the virtually sterile womb to a planet full of antigens ensuing rapid microbial colonization of the mucosa. 56 Thus, the newborn must develop and use different strategies such as avoidance of excessive responses to overcome these challenges, in part by the immunosuppressive role of Bregs. This is due to the need for tolerance that newborns are at relatively increased risk of developing severe infections though they have the ability to fight against pathogenic microbes.…”

Section: During Pregnancy and Early Lifementioning

confidence: 99%

See 1 more Smart Citation

The Role of Regulatory B Cells in Health and Diseases: A Systemic Review

Abebe¹,

Dejenie²,

Ayele³

et al. 2021

JIR

View full text Add to dashboard Cite

Section: During Pregnancy and Early Lifementioning

confidence: 99%

“…Moreover, the elevated level of IL-10 secreting Bregs have been associated with good prognosis in late-onset neonatal sepsis. 56…”

Section: During Pregnancy and Early Lifementioning

confidence: 99%

The Role of Regulatory B Cells in Health and Diseases: A Systemic Review

Abebe¹,

Dejenie²,

Ayele³

et al. 2021

JIR

View full text Add to dashboard Cite

“…Deficiencies in the number and function of these cells have been first reported in patients with systemic lupus erythematosus (Blair et al, 2010), spreading then to other autoimmune diseases (multiple sclerosis, rheumatoid arthritis, Sjögren's syndrome), allergic rhinitis, and chronic infections (Abebe et al, 2021). Furthermore, CD19 + CD24 high CD38 high Breg represents a high percentage of the bulk of B lymphocyte in cord and peripheral blood of healthy neonate and was found increased in late-onset sepsis, linking these cells with pregnancy success (Li et al, 2018). On the other hand, CD19 + CD24 high CD27 + B cell subset harnesses its immunomodulatory activity mostly by regulating the production of pro-inflammatory cytokines, tumor necrosis factor (TNF)-a in monocytes and interferon (IFN)-g in CD4 + T cells (Iwata et al, 2011;Hasan et al, 2019;Jansen et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Trypanosoma cruzi Induces Regulatory B Cell Alterations in Patients With Chronic Chagas Disease

Girard

Ossowski

Muñoz-Calderón

et al. 2021

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

The clinical evolution of patients with chronic Chagas disease (CCD) is mainly associated with an excessive inflammation and a defective immunomodulatory profile caused by the interaction between T. cruzi and the host. Regulatory B (Breg) cells exert immune suppression mostly through IL-10 production (B10 cells), but also through IL-10-independent mechanisms. Previously, we demonstrated that CCD patients with cardiomyopathy show changes in the ex vivo Breg cell phenotypic distribution although maintain IL-10 production capacity. Here, we sought to identify potential alterations on Breg cells upon in vitro stimulation. Isolated B cells from CCD patients with or without cardiomyopathy and non-infected (NI) donors were stimulated with T. cruzi lysate or CpG + CD40L, and characterized by flow cytometry based on the expression of CD24, CD27, CD38, and the regulatory molecules IL-10 and PD-L1. IL-10 and IL-17 secretion in the supernatant of B cells was evaluated by ELISA. Data showed that T. cruzi stimulation diminished the expression of CD24 and CD38 on CD27− B cells while reducing the percentage of CD24high inside CD27+ B cells. Furthermore, T. cruzi induced a regulatory B cell phenotype by increasing B10 cells and IL-10 secretion in all the groups. The innate-like B10 cells expansion observed in patients with cardiomyopathy would be associated with CD27− B10 cell subsets, while no predominant phenotype was found in the other groups. Patients with cardiomyopathy also displayed higher IL-17 secretion levels in T. cruzi–activated B cells. CpG + CD40L stimulation revealed that B cells from CCD patients and NI donors had the same ability to differentiate into B10 cells and secrete IL-10 in vitro. Additionally, CCD patients showed an increased frequency of CD24−CD27− B cells and a reduction in the percentage of CD24highCD27+ Breg cells, which appeared to be inversely correlated with the presence of T. cruzi DNA in blood. Finally, CCD patients exhibited a higher frequency of PD-L1+ B cells in T. cruzi–stimulated samples, suggesting that IL-10-independent mechanisms could also be tangled in the control of inflammation. Altogether, our results provide evidence about the potential role of Breg cells in the immune response developed against T. cruzi and its contribution to chronic Chagas cardiomyopathy.

show abstract

“…NF-B cells and naive B cells also decrease early after vaccination, suggesting they may respond to bacterial products and turn into PCs. NF-B cells may also contribute to protection against neonatal sepsis (76). Elevated levels of circulating CD19 + CD38 hi CD24 hi NF-B cells correlated with protection.…”

Section: Nf-b Cells Increase After Viral Infections the Frequency Of Nf-b Cells Increases During Some Viral Infections Includingmentioning

confidence: 97%

The Plasticity of Newly Formed B Cells

Giltiay

Giordano

Clark

2019

The Journal of Immunology

View full text Add to dashboard Cite

Newly formed B cells (NF–B cells) that emerge from the bone marrow to the periphery have often been referred to as immature or transitional B cells. However, NF–B cells have several striking characteristics, including a distinct BCR repertoire, high expression of AID, high sensitivity to PAMPs, and the ability to produce cytokines. A number of findings do not support their designation as immature because NF–B cells have the potential to become Ab-producing cells and to undergo class-switch recombination. In this review, we provide a fresh perspective on NF–B cell functions and describe some of the signals driving their activation. We summarize growing evidence supporting a role for NF–B cells in protection against infections and as a potential source of autoantibody-producing cells in autoimmune diseases such as systemic lupus erythematosus.

show abstract

Marked elevation of circulating CD19 + CD38 hi CD24 hi transitional B cells give protection against neonatal sepsis

Abstract: The level of IL-10 producing Trans was significantly elevated in peripheral blood of good prognosis newborns with LOS and might contribute to the successful immunoprotective state of the disease.

Cited by 20 publications

References 36 publications

The Role of Regulatory B Cells in Health and Diseases: A Systemic Review

The Role of Regulatory B Cells in Health and Diseases: A Systemic Review

Trypanosoma cruzi Induces Regulatory B Cell Alterations in Patients With Chronic Chagas Disease

The Plasticity of Newly Formed B Cells

Contact Info

Product

Resources

About