Marked alterations in the cellular localisation and levels of apolipoprotein E following acute subdural haematoma in rat

Horsburgh, Karen; Fitzpatrick, M O; Nilsen, Margaret; Nicoll, James A. R.

doi:10.1016/s0006-8993(97)00411-3

Cited by 46 publications

(28 citation statements)

References 20 publications

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“…ApoE then forms a non-polar molecule complex with cholesterol, and is taken up by the neuronal membrane surface of very low-density lipoprotein (VLDL) receptor, into regional or distal dendrites of neurons, occur for the regeneration of the cytoplasm and synapses (Liu et al, 2005). Thirty minutes after cerebral contusion, neurons within the cortical contusion foci had significant but weak staining of ApoE compared to the controls (P < 0.01), which is consistent with a previous study by Horsburgh et al (1997). The data were earlier than Orihara's report (Orihara and Nakasomo, 2002), which could be due to species differences, and rats were less tolerated than human.…”

Section: Discussionsupporting

confidence: 89%

ApoE and S-100 expression and its significance in the brain tissue of rats with focal contusion

Wang¹,

Chai²,

Yang³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. This study explored the effect of focal cerebral contusion on the expression of ApoE and S-100, and its significance in determining the time of brain injury. Based on a rat model of cerebral contusion, immunohistochemistry was used to analyze the expressions of S-100 and ApoE at different time points after injury. Thirty minutes following cerebral contusion, ApoE protein expression was significantly increased in cortex neurons (P < 0.01), and S-100 protein expression was significantly (P < 0.001) elevated 2 h after cerebral contusion. Over time, the number of ApoE and S-100 positively expressing cells gradually increased. Three days after injury, ApoE was widely distributed throughout the tissue and the number of ApoE-positive cells and staining intensity reached a peak. ApoE expression decreased after this time point. Five days after cerebral 19275-19281 (2015) contusion, the number of S-100-positive cells reached a peak level of expression higher than that in the control group. Our data demonstrate that the expression of ApoE and S-100 correlated with the progression of focal cerebral contusion. This suggests that both proteins may serve as effective biomarkers of focal cerebral contusions.

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Section: Discussionsupporting

confidence: 89%

ApoE and S-100 expression and its significance in the brain tissue of rats with focal contusion

Wang¹,

Chai²,

Yang³

et al. 2015

Genet. Mol. Res.

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“…Animal models have shown increased expression of apo E and increased neuronal uptake after ischemic 38 and hemorrhagic insults. 39 That apo E is important in neuronal injury has been suggested in APOEdeficient (knockout) mice, in which a larger infarct volume occurs after focal cerebral ischemia. 40 The mice also have a prolonged intrinsic clotting time and elevated fibrinogen.…”

Section: Discussionmentioning

confidence: 99%

The Apolipoprotein E ε4 Allele and Outcome in Cerebrovascular Disease

McCarron

Muir

Weir

et al. 1998

Stroke

117

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Background and Purpose-Polymorphism of the apolipoprotein E gene (APOE) may influence outcome after traumatic brain injury and intracerebral hemorrhage, with the ⑀4 allele being associated with poorer prognosis. We investigated APOE allele distribution in acute stroke and the effect of the ⑀4 allele on outcome. Methods-APOE genotypes were determined in 714 stroke patients: 640 ischemic stroke and 74 intracerebral hemorrhage patients. The survival effect of the ⑀4 allele was assessed with the use of a stratified log-rank test. A Cox proportional hazards regression model was used to estimate the independent effect of ⑀4 dose (0, 1, or 2) on survival, and logistic regression was used to determine the effect on 3-month outcome (good if alive at home, poor if in care or dead). Results-Allele distribution matched the general population with no difference between the ischemic and hemorrhagic groups. Survival in the entire cohort was unaffected by ⑀4 dose. Improved survival with increasing ⑀4 dose was found in the ischemic group (relative hazardϭ0.76 per allele; Pϭ0.04). If transient ischemic attacks were excluded, a trend for improved survival persisted (Pϭ0.06). With intracerebral hemorrhage, a trend was seen toward reduced survival with ⑀4 (Pϭ0.07, log-rank test). Three-month outcome in the ischemic group was unaffected by ⑀4 dose, and a trend toward poorer outcome with ⑀4 was seen for intracerebral hemorrhage (Pϭ0.10). Conclusions-The APOE ⑀4 allele had divergent effects on survival and outcome in ischemic and hemorrhagic strokes in this population. The reported adverse effect on patients with intracerebral hemorrhage was supported. The favorable survival effect on ischemic stroke patients requires further study. (Stroke. 1998;29:1882-1887.)

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“…Animal models have shown increased expression of apo E and increased neuronal uptake after ischemic (Horsburgh & Nicoll, 1995) and hemorrhagic insults (Horsburgh, 1997). That apo E is important in neuronal injury has been suggested in APOEdeficient (knockout) mice, in which a larger infarct volume occurs after cerebral ischemia (Laskowitz et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Apolipoprotein E Polymorphism and Stroke in a Population From Eastern Turkey

Düzenli

Pirim

Gepdíremen

et al. 2004

Journal of Neurogenetics

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Human apolipoprotein E (apo E) alleles are polymorphic with significantly different frequencies among different ethnic groups and have been associated with increased risk of coronary heart disease, and postulated as a major genetic susceptibility locus for Alzheimer's disease. Studies undertaken in different populations have shown different association patterns between apo E genotype and stroke. The aim of this study was to determine the risk of apo E genotype in stroke patients living in the eastern part of Turkey. The apo E genotypes and allele frequencies of 229 individuals from the same geographic area were determined by polymerase chain reaction and restriction fragment length polymorphism, of which 103 were patients with a documented history of stroke without other apparent dementia and 126 age-matched healthy subjects as a control group. A reduced E3=4 genotype frequency was found in subjects with stroke and the E2=3 Address correspondence to Dr. Selma DUZENLI, Ataturk University, Medical Faculty, Department of Pharmacology, 25000 Erzurum, Turkey. E-mail: selmaduzenli@hotmail.com 365 genotype frequency was elevated in patients with previous stroke. There was no association between apo E e4 allele and stroke. The APOE alleles had divergent effects in this population. Association between APOE (the gene) alleles and stroke in this population may be altered due to interaction with other genetic effects. The effects of APOE alleles and genotypes require further study in different populations.

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Marked alterations in the cellular localisation and levels of apolipoprotein E following acute subdural haematoma in rat

Cited by 46 publications

References 20 publications

ApoE and S-100 expression and its significance in the brain tissue of rats with focal contusion

ApoE and S-100 expression and its significance in the brain tissue of rats with focal contusion

The Apolipoprotein E ε4 Allele and Outcome in Cerebrovascular Disease

Apolipoprotein E Polymorphism and Stroke in a Population From Eastern Turkey

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