Marjolin's Ulcer: MR Appearance

Chiang, Kuo-Hsien; Chou, Andy Shau-Bin; Hsu, Yung-Hsiang; Lee, Sea-Kiat; Lee, Chau-Chin; Yen, Pao-Sheng; Ling, Chang-Ming; Lee, Wei-Hsing; Lin, Chin-Lon; Chang, Pau-Yang

doi:10.2214/ajr.04.1921

Cited by 29 publications

(37 citation statements)

References 7 publications

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“…Once the diagnosis of SCC has been histologically established, further diagnostic workup is required to evaluate patients with respect to local muscle or bone invasion as well as lymph node or distant metastasis. Here, plain X‐rays and magnetic resonance imaging (MRI) represent the methods of choice .…”

Section: Discussionmentioning

confidence: 99%

Squamous cell carcinomas in chronic venous leg ulcers. Data of the German Marjolin Registry and review

Reich‐Schupke

Doerler

Wollina³

et al. 2015

J Deutsche Derma Gesell

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Section: Discussionmentioning

confidence: 99%

Squamous cell carcinomas in chronic venous leg ulcers. Data of the German Marjolin Registry and review

Reich‐Schupke

Doerler

Wollina³

et al. 2015

J Deutsche Derma Gesell

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“…The most valuable study is MRI because it will demonstrate the margins and extent of the lesion. MRI provides excellent tissue contrast especially with contrast enhancement [13].…”

Section: Discussionmentioning

confidence: 99%

Development of Marjolin’s ulcer within one month of burn injury with synchronous primary lung squamous cell carcinoma in an elderly patient: report of a case with allelotyping

2010

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Marjolin's ulcer defines the occurrence of malignancy, usually squamous cell carcinoma, in the setting of a post-traumatic scar often following thermal injury. The latency period from the time of injury to the onset of malignant transformation averages 30 years with the earliest documented incidence occurring 6 weeks after injury. In addition, the occurrence of multiple primary malignancies is a rare event. To our knowledge, we report the first case in the literature of a well-differentiated squamous cell carcinoma developing within 1 month of thermal injury to an elderly patient's right index finger with an incidental synchronous primary lung moderately differentiated squamous cell carcinoma that was morphologically and genetically different as confirmed by allelotyping. There is scant precedent literature on acute Marjolin's ulcers, and the most acute cases have arisen 6 weeks post-burn. There is also little published literature on the incidence of multiple primary malignancies. The quoted incidence of this event is <1%. Clinicians should be aware of the possibility of malignant transformation at the site of prior thermal injury. Biopsy remains the gold standard for diagnosis for Marjolin's ulcer. MRI is the most important diagnostic imaging tool because it will demonstrate the margins and extent of the lesion. Due to the aggressive nature of Marjolin's ulcer, treatment is usually surgical and dependent upon grading. When multiple lesions are detected after staging of a presumed neoplasm, the possibility of multiple primary maligancies should be considered. Allelotyping is a process that can be utilized to determine if multiple masses are related.

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“…Amputation is required in extremity lesions with bone involvement by cancer and invasion of major neurovascular structures by cancer [10]. Before morbid surgery like amputation is undertaken, the bone erosion by tumour should be differentiated from infection (osteomyelitis).…”

Section: Editorialmentioning

confidence: 99%

Marjolin’s Ulcer

Goel¹

2017

CDOAJ

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Marjolin's Ulcer: MR Appearance

Cited by 29 publications

References 7 publications

Squamous cell carcinomas in chronic venous leg ulcers. Data of the German Marjolin Registry and review

Squamous cell carcinomas in chronic venous leg ulcers. Data of the German Marjolin Registry and review

Development of Marjolin’s ulcer within one month of burn injury with synchronous primary lung squamous cell carcinoma in an elderly patient: report of a case with allelotyping

Marjolin’s Ulcer

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