Marital status is an independent prognostic factor in inflammatory breast cancer patients: an analysis of the surveillance, epidemiology, and end results database

Liu, Yanling; Wang, Dunwei; Yang, Zhu-Chun; Ma, Rui; Zhong, Li; Wei, Suo; Zhao, Zhuang; Li, Zhiwen

doi:10.1007/s10549-019-05385-8

Cited by 43 publications

(45 citation statements)

References 30 publications

(32 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For clinicians, more care should be taken when applying RTCT in tumors sized <2 cm. Additionally, after adjusting for several factors, we found that divorced, separated, or widowed women had worse OS than married women, which confirms the benefits of marriage on survival found by previous studies regarding vulvar, ovarian, endometrial, and breast cancers (32)(33)(34)(35). The most likely reason for the survival benefit from marriage is that divorced, separated, or widowed patients have worse adherence to prescribed treatments than married patients.…”

Section: Discussionsupporting

confidence: 87%

Radiotherapy Plus Chemotherapy Is Associated With Improved Survival Compared to Radiotherapy Alone in Patients With Primary Vaginal Carcinoma: A Retrospective SEER Study

Zhou

Yue

2020

Front. Oncol.

View full text Add to dashboard Cite

BackgroundThe efficacy of radiotherapy plus chemotherapy (RTCT) versus radiotherapy alone (RT) in the treatment of primary vaginal carcinoma has been controversial. We aimed to evaluate the up-to-date efficacy of RTCT on primary vaginal carcinoma in a real-world cohort.MethodsWe performed a retrospective analysis in patients with primary vaginal carcinoma retrieved from the Surveillance, Epidemiology, and End Results Program database from 2004 to 2016. Kaplan–Meier survival curves were plotted and compared by the log-rank test. Inverse probability weighting (IPW)-adjusted multivariate Cox proportional hazards and Fine-Gray competing-risk model was applied.ResultsOf the 1,813 qualified patients with primary vaginal carcinoma from 2004 to 2016, 1,137 underwent RTCT and 676 underwent RT. The median survival time was 34 months for the RT group and 63 months for the RTCT group. RTCT was significantly associated with improved overall survival (unadjusted HR = 0.71, 95% CI 0.62–0.82, p < 0.001; adjusted HR = 0.73, 95% CI 0.63–0.84, p < 0.001) and cancer-specific survival (unadjusted sHR = 0.81, 95% CI 0.69–0.95, p = 0.012; adjusted sHR = 0.81, 95% CI 0.69–0.96, p = 0.016). Age, histological type, tumor size, surgery, and FIGO stage were all independent prognostic factors for survival (p < 0.05 for all). Subgroup analysis demonstrated that RTCT was significantly associated with better survival in most subgroups, except for those with adenocarcinoma, tumor size <2 cm, or FIGO stage I. Moreover, sensitivity analysis did not alter the beneficial effects of RTCT.ConclusionRTCT is significantly correlated with prolonged survival in patients with primary vaginal carcinoma. RTCT should be applied to most patients with primary vaginal carcinoma instead of RT alone, except for those with adenocarcinoma, tumor size <2 cm, or FIGO stage I.

show abstract

Section: Discussionsupporting

confidence: 87%

Radiotherapy Plus Chemotherapy Is Associated With Improved Survival Compared to Radiotherapy Alone in Patients With Primary Vaginal Carcinoma: A Retrospective SEER Study

Zhou

Yue

2020

Front. Oncol.

View full text Add to dashboard Cite

show abstract

“…For example, Zhou et al proved that marital status was an independent prognostic risk factor for patients with pancreatic endocrine cancer 18 . Similar findings have also been discovered in breast cancer and nasopharyngeal carcinoma 15,29 . The above researches all exhibited that the prognosis of married patients is remarkably better than that of unmarried ones.…”

Section: Discussionsupporting

confidence: 86%

Marital status and survival of patients with colorectal signet ring cell carcinoma: a population-based study

Yang

et al. 2020

Sci Rep

View full text Add to dashboard Cite

The prognostic role of marital status on colorectal signet ring cell carcinoma (SRCC) has not been studied. In this study, the correlation of marital status with prognosis of colorectal SRCC was analyzed. Eligible subjects were extracted from the Surveillance, Epidemiology, and End Results (SEER) dataset from 2004 to 2015, followed by comparison of cancer-specific survival (CSS) and overall survival (OS) between married and unmarried group. 3152 patients were identified including 1777 married patients (56.38%). Married populations tended to be more patients aged < 65, male, receiving chemotherapy, and less black race and large tumor size compared to unmarried group (all P < 0.05).Moreover, 5-year CSS (30.04% vs. 28.19%, P = 0.0013) and OS rates (26.68% vs. 22.94%, P < 0.0001) were superior in married population. Multivariate analysis revealed that marital status was an independent favorable prognostic indicator, and married population had better CSS (HR: 0.898; 95% CI: 0.822–0.980; P = 0.016) and OS (HR: 0.898; 95%CI: 0.827–0.975; P = 0.011).In addition, CSS as well as OS were superior in married populations than unmarried ones in most subgroups. Marital status was an independent prognostic factor for survival in patients with colorectal SRCC. Additionally, married patients obtained better survival advantages.

show abstract

“…Current data suggest that more single women received an initial diagnosis with breast cancer in the ED than married women. This finding agrees with the literature that single women had a delay to diagnosis and worse prognosis more often than married women [ 8 , 18 - 20 ]. This observation can be attributed to the fact that single women are more likely to lack social and financial support regarding medical issues.…”

Section: Discussionsupporting

confidence: 93%

Impact of Healthcare Access Disparities on Initial Diagnosis of Breast Cancer in the Emergency Department

Yee¹,

Mazumder²,

Dong³

et al. 2020

Cureus

View full text Add to dashboard Cite

Breast cancer continues to be the second leading cause of cancer deaths in women in the United States. This is more noticeable in communities with pronounced healthcare disparities. The aim of this study was to investigate the different demographics that might play a role in the detection of breast cancer in a county hospital emergency department (ED). A retrospective study was conducted of female patients diagnosed with breast cancer over a five-year period (1/1/2015 to 12/31/2018). Patients with breast cancer as the primary or secondary diagnosis were identified. This study shows that 66 (73.3%) women diagnosed in the ED were Hispanic or African American. There was a significant delay (a median of 461 days) in the time between the diagnosis of suspected breast cancer in the ED to their follow-up visit with definitive diagnosis in a primary care clinic. These findings suggest that women with a suspected breast cancer diagnosis who are seen in a safety net hospital and have Medicaid funding may have significant delays before final diagnosis is made. Patient demographics could have an impact on the patients' access to screening and regular healthcare visits, hindering an early breast cancer diagnosis by a primary care provider.

show abstract

Marital status is an independent prognostic factor in inflammatory breast cancer patients: an analysis of the surveillance, epidemiology, and end results database

Cited by 43 publications

References 30 publications

Radiotherapy Plus Chemotherapy Is Associated With Improved Survival Compared to Radiotherapy Alone in Patients With Primary Vaginal Carcinoma: A Retrospective SEER Study

Radiotherapy Plus Chemotherapy Is Associated With Improved Survival Compared to Radiotherapy Alone in Patients With Primary Vaginal Carcinoma: A Retrospective SEER Study

Marital status and survival of patients with colorectal signet ring cell carcinoma: a population-based study

Impact of Healthcare Access Disparities on Initial Diagnosis of Breast Cancer in the Emergency Department

Contact Info

Product

Resources

About