Marital Status and Survival of Patients with Chondrosarcoma: A Population-Based Analysis

Gao, Zhongyang; Ren, Fenggang; Song, Hui; Wang, Yudong; Wang, Yibin; Zhu, Jun‐Jie; He, Xijing

doi:10.12659/msm.911673

Cited by 41 publications

(48 citation statements)

References 42 publications

(58 reference statements)

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“…At present, the role of sex in CS is still controversial. Some previous studies showed that sex was an independent risk factor, while another several studies revealed that sex was not a prognostic factor . In this study, the ratio of male to female patients was ~1.6:1, which was consistent with such ratios in previous studies .…”

Section: Discussionsupporting

confidence: 91%

“…Some previous studies showed that sex was an independent risk factor, while another several studies revealed that sex was not a prognostic factor. [21][22][23][24] In this study, the ratio of male to female patients was ~1.6:1, which was consistent with such ratios in previous studies. 23,25 Being female was associated with a better prognosis; thus sex was an independent prognostic factor with obvious effects on OS of patients with pelvic CS.…”

Section: Discussionsupporting

confidence: 91%

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Prognostic nomograms to predict overall survival and cancer‐specific survival in patients with pelvic chondrosarcoma

et al. 2019

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Background The pelvis is the most common site of chondrosarcoma (CS), and the prognosis for patients with pelvic CS is worse than that for patients with CS in the extremities. However, clinicians have had few tools for estimating the likelihood of survival in patients with pelvic CS. Our aim was to develop nomograms to predict survival of patients with pelvic CS. Methods Data from the Surveillance, Epidemiology, and End Results (SEER) database of patients with pelvic CS between 2004 and 2016 were retrieved for retrospective analysis. Univariate and multivariate Cox analyses were used to identify independent prognostic factors. On the basis of the results of the multivariate analyses, nomograms were constructed to predict the likelihood of 3‐ and 5‐year overall survival (OS) and cancer‐specific survival (CSS) of patients with pelvic CS. The concordance index (C‐index) and calibration curves were used to test the models. Results In univariate and multivariate analyses of OS, sex, pathologic grade, tumor size, tumor stage, and surgery were identified as the independent risk factors. In univariate and multivariate analyses of CSS, pathologic grade, tumor size, tumor stage, and surgery were identified as the independent risk factors. These characteristics except surgery were integrated in the nomograms for predicting 3‐ and 5‐year OS and CSS, and the C‐indexes were 0.758 and 0.786, respectively. Conclusion The nomograms precisely and individually predict OS and CSS of patients with pelvic CS and could aid in personalized prognostic evaluation and individualized clinical decision‐making.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

Prognostic nomograms to predict overall survival and cancer‐specific survival in patients with pelvic chondrosarcoma

et al. 2019

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“…Marital status has always been closely related to the prognosis of cancer. Many studies have confirmed that marital status may affect the prognosis of various tumors, including osteosarcoma [11], chondrosarcoma [12], penile cancer [13], and breast cancer [14]. However, retrospective or prospective studies have not been conducted to report whether marital status affects the survival of adult patients with chordoma.…”

Section: Introductionmentioning

confidence: 99%

Influence of marital status on overall survival in adult patients with chordoma: a SEER-based study

Tang¹,

Wang

Lu³

et al. 2020

J Orthop Surg Res

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Background: As a rare primary bone tumor, no studies have reported the relationship between prognosis and marital status in patients with chordoma. Methods: We classified patients with chordoma identified from the Surveillance, Epidemiology, and End Results (SEER) database from 1975 to 2016 into four groups: married, divorced/separated, widowed, and single groups. Kaplan-Meier curves with log-rank test and Cox regression were used to analyze the effect of marital status on overall survival (OS). Results: A total of 1080 patients were included in the study: 700 (64.8%) were married, 88 (8.1%) were divorced/ separated, 78 (7.2%) were widowed, and 214 (19.8%) were single. Among the 4 groups, the 5-year OS (45.2%), 10year OS (12.5%), and median OS (56.0 months) were the lowest in the widowed group. After including age, sex, primary site, marital status, disease stage, tumor size, histological type, and treatment pattern, multivariate analysis showed that marital status was still an independent risk factor for patients with chordoma, and widowed patients had the lowest OS (hazard ratio [HR] 1.71; 95% confidence interval [CI] 1.25-2.33, p < 0.001) compared with married patients. Similar results were observed after stratifying the primary site and disease stage. Conclusion: Marital status was an independent prognostic indicator for adult patients with chordoma, and marital status was conducive to patient survival. Compared with married patients, widowed patients have a higher risk of death.

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“…Marital status has always been closely related to the prognosis of cancer. Many studies have confirmed that marital status may affect the prognosis of various tumors, including osteosarcoma(11), chondrosarcoma (12), penile cancer (13) and breast cancer (14). However, retrospective or prospective studies have not been conducted to report whether marital status affects the survival of adult patients with chordoma.…”

Section: Introductionmentioning

confidence: 99%

Influence of marital status on overall survival in adult patients with chordoma: A SEER-based study

Tang¹,

Wang

Lu³

et al. 2020

Preprint

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Background. As a rare primary bone tumour, no studies have reported the relationship between prognosis and marital status in patients with chordoma.Methods. We classified patients with chordoma identified from the Surveillance, Epidemiology, and End Results (SEER) database from 1975 to 2016 into four groups: married, divorced/separated, widowed and single groups. Kaplan-Meier curves with log-rank test and Cox regression were used to analyse the effect of marital status on overall survival (OS). Results.A total of 1,080 patients were included in the study: 700 (64.8%) were married, 88 (8.1%) were divorced/separated, 78 (7.2%) were widowed, and 214 (19.8%) were single. Among the four groups, the 5-year OS (45.2%), 10-year OS (12.5%) and median OS (56.0 months) were the lowest in the widowed group. After including age, sex, primary site, marital status, disease stage, tumor size, histological type, and treatment pattern, multivariate analysis showed that marital status was still an independent risk factor for patients with chordoma, and widowed patients had the lowest OS (hazard ratio [HR]: 1.71; 95% confidence interval [CI]: 1.25-2.33, p<0.001) compared with married patients.Similar results were observed after stratifying the primary site and disease stage. Conclusion.Marital status was an independent prognostic indicator for adult patients with chordoma, and marital status was conducive to patient survival. Compared with married patients, widowed patients have a higher risk of death. colleagues across the United States and those at Information Management Services, Inc., who have been involved with the Surveillance, Epidemiology and End Results (SEER) Program.

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Marital Status and Survival of Patients with Chondrosarcoma: A Population-Based Analysis

Cited by 41 publications

References 42 publications

Prognostic nomograms to predict overall survival and cancer‐specific survival in patients with pelvic chondrosarcoma

Prognostic nomograms to predict overall survival and cancer‐specific survival in patients with pelvic chondrosarcoma

Influence of marital status on overall survival in adult patients with chordoma: a SEER-based study

Influence of marital status on overall survival in adult patients with chordoma: A SEER-based study

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