Marital status and survival in patients with soft tissue sarcoma: A population‐based, propensity‐matched study

Zhang, Shilong; Wang, Wen-Rong; Liu, Ze‐juan; Wang, Zhiming

doi:10.1002/cam4.1802

Cited by 31 publications

(36 citation statements)

References 39 publications

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“…Marital status is widely considered to be an independent prognostic factor for many malignancies [17][18][19][20]. However, the effect of marital status on adult patients with chordoma has not been fully investigated.…”

Section: Discussionmentioning

confidence: 99%

Influence of marital status on overall survival in adult patients with chordoma: a SEER-based study

Tang¹,

Wang

Lu³

et al. 2020

J Orthop Surg Res

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Background: As a rare primary bone tumor, no studies have reported the relationship between prognosis and marital status in patients with chordoma. Methods: We classified patients with chordoma identified from the Surveillance, Epidemiology, and End Results (SEER) database from 1975 to 2016 into four groups: married, divorced/separated, widowed, and single groups. Kaplan-Meier curves with log-rank test and Cox regression were used to analyze the effect of marital status on overall survival (OS). Results: A total of 1080 patients were included in the study: 700 (64.8%) were married, 88 (8.1%) were divorced/ separated, 78 (7.2%) were widowed, and 214 (19.8%) were single. Among the 4 groups, the 5-year OS (45.2%), 10year OS (12.5%), and median OS (56.0 months) were the lowest in the widowed group. After including age, sex, primary site, marital status, disease stage, tumor size, histological type, and treatment pattern, multivariate analysis showed that marital status was still an independent risk factor for patients with chordoma, and widowed patients had the lowest OS (hazard ratio [HR] 1.71; 95% confidence interval [CI] 1.25-2.33, p < 0.001) compared with married patients. Similar results were observed after stratifying the primary site and disease stage. Conclusion: Marital status was an independent prognostic indicator for adult patients with chordoma, and marital status was conducive to patient survival. Compared with married patients, widowed patients have a higher risk of death.

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Section: Discussionmentioning

confidence: 99%

Influence of marital status on overall survival in adult patients with chordoma: a SEER-based study

Tang¹,

Wang

Lu³

et al. 2020

J Orthop Surg Res

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show abstract

“…Marriage is one of the most important source of social support, which affects physical health through integrative physiological mechanisms [6]. Previous studies have pointed out that married patients tend to have better survival outcome in several cancer types [7][8][9][10][11][12][13][14][15]. However, whether marriage has a "protective" effect for G-NEN patients has not yet been established.…”

Section: Introductionmentioning

confidence: 99%

Marital status, an independent predictor for survival of gastric neuroendocrine neoplasm patients: a SEER database analysis

Zhou

Zheng

et al. 2020

BMC Endocr Disord

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Background: Marital status proves to be an independent prognostic factor in a variety of cancers. However, its prognostic impact on gastric neuroendocrine neoplasms (G-NEN) has not been investigated. Methods: We identified 3947 G-NEN patients from the Surveillance, Epidemiology, and End Results (SEER) database. Meanwhile, propensity scores for marital status were used to match 506 unmarried patients with 506 married patients. We used Kaplan-Meier method and multivariate Cox regression to analyse the association between marital status and the overall survival (OS) and G-NEN cause-specific survival (CSS) before matching and after matching. Results: Married patients enjoyed better OS and CSS, compared with divorced/separated, single, and widowed patients. Multivariate Cox regression analysis indicated that unmarried status was associated with higher mortality hazards for both OS and CSS among G-NEN patients. Additionally, widowed individuals had the highest risks of overall (adjusted hazard ratio (HR): 1.56, 95% confidence interval (CI): 1.35-1.81, P < 0.001) and cancer-specific mortality (adjusted HR: 1.33, 95% CI: 1.05-1.68, P = 0.02) compared to other unmarried groups in both males and females. Furthermore, unmarried status remained an independent prognostic and risk factor for both OS (HR 1.51, 95% CI 1.19-1.90, P = 0.001) and CSS (HR 1.50, 95% CI 1.10-2.05, P = 0.01) in 1:1 propensity score-matched analysis. Conclusion: Marital status was an independent prognostic factor for G-NEN. Meanwhile, widowed patients with G-NEN had the highest risk of death compared with single, married, and divorced/separated patients.

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“…Recently, results from considerable literature have disclosed that that married patients have superior survival compared to the unmarried in various cancers5, such as soft tissue sarcoma6, liver cancer7 and colon cancer8. This interesting phenomenon arise much public attentions.…”

Section: Introductionmentioning

confidence: 99%

A real-world 1:1 propensity-matched study revealed unmarried status was independently associated with worse survival for patients with renal clear cell carcinoma

Zhang

Sun

et al. 2019

J. Cancer

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Background: Marital status has been reported as an independent prognostic factor for survival in various cancers, but it has been rarely studied in renal clear cell carcinoma (ccRCC). In this study, we aimed to assess the impact of marital status on the survival of ccRCC patients. Methods: We retrospectively investigated the Surveillance, Epidemiology, and End Results (SEER) database and identified 68599 of ccRCC patients between 1973 and 2015. These patients were divided into married, single, divorced and widowed groups. The survival differences among these groups were assessed by Kaplan-Meier method and log-rank test. Multivariate Cox regression analyses were performed to identify the overall survival (OS) and cancer-specific survival (CSS) independent factors. Furthermore, 1:1 propensity score matching (PSM) analysis was performed to minimize the potential confounding factors. Results: Of the 68599 ccRCC patients, 44553 (64.95%) patients were married, 7410 (10.80%) were divorced, 10663 (15.54%) were single, and 5973 (8.71%) were widowed. The 5-year OS was 79.0%, 73.8%, 77.3%, and 66.4 % in the married, divorced, single, and widowed groups, respectively (p = 0.001) and the corresponding 5-year CSS rates were 85.5%, 83.3%, 80.8%, 76.5%, respectively. Multivariate Cox regression analysis marital status was the independent prognostic factor for OS and CSS. Compared with the married patients, the divorced, single, and widowed patients faced increased higher mortality risks for OS and CSS. In stratified analyses by sex, surgery conditions and cancer stages, those unmarried patients still had worse prognosis. The results were further confirmed in the 1: 1 matched group. Conclusion: Unmarried ccRCC patients experienced worse survival than their married counterparts. Among the unmarried patients, the widowed suffered the highest mortality risks for OS and CSS.

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Marital status and survival in patients with soft tissue sarcoma: A population‐based, propensity‐matched study

Cited by 31 publications

References 39 publications

Influence of marital status on overall survival in adult patients with chordoma: a SEER-based study

Influence of marital status on overall survival in adult patients with chordoma: a SEER-based study

Marital status, an independent predictor for survival of gastric neuroendocrine neoplasm patients: a SEER database analysis

A real-world 1:1 propensity-matched study revealed unmarried status was independently associated with worse survival for patients with renal clear cell carcinoma

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