Marine Sponge Lectins: Actual Status on Properties and Biological Activities

Filho, Sandro Mascena Gomes; Cardoso, Juscélio Donizete; Anaya, Katya; Nascimento, Edilza Silva do; Lacerda, José Thalles Jocelino Gomes de; Mioso, Roberto; Santi-Gadelha, Tatiane; Gadelha, Carlos Alberto de Almeida

doi:10.3390/molecules20010348

Cited by 17 publications

(9 citation statements)

References 34 publications

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“…Once isolated in a laboratory, these substances can display strong and often highly specific biological activities such as antibacterial, antiviral, antifungal, anti-prion, antimalarial, anti-inflammatory and immune or neuro-suppressive qualities [ 6 , 7 , 8 , 9 ]. They exhibit, moreover, pronounced cytotoxic activity towards certain types of malignant cell lines, which make them potential drug targets for the treatment of multifactorial diseases such as cancer [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Compounds Derived from Marine Sponges. A Review (2010–2012)

et al. 2017

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This extensive review covers research published between 2010 and 2012 regarding new compounds derived from marine sponges, including 62 species from 60 genera belonging to 33 families and 13 orders of the Demospongia class (Porifera). The emphasis is on the cytotoxic activity that bioactive metabolites from sponges may have on cancer cell lines. At least 197 novel chemical structures from 337 compounds isolated have been found to support this work. Details on the source and taxonomy of the sponges, their geographical occurrence, and a range of chemical structures are presented. The compounds discovered from the reviewed marine sponges fall into mainly four chemical classes: terpenoids (41.9%), alkaloids (26.2%), macrolides (8.9%) and peptides (6.3%) which, along with polyketides, sterols, and others show a range of biological activities. The key sponge orders studied in the reviewed research were Dictyoceratida, Haplosclerida, Tetractinellida, Poecilosclerida, and Agelasida. Petrosia, Haliclona (Haplosclerida), Rhabdastrella (Tetractinellida), Coscinoderma and Hyppospongia (Dictyioceratida), were found to be the most promising genera because of their capacity for producing new bioactive compounds. Several of the new compounds and their synthetic analogues have shown in vitro cytotoxic and pro-apoptotic activities against various tumor/cancer cell lines, and some of them will undergo further in vivo evaluation.

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Section: Introductionmentioning

confidence: 99%

Cytotoxic Compounds Derived from Marine Sponges. A Review (2010–2012)

et al. 2017

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“…Marine sponges are widely distributed across the various depths of the ocean floor with a few being present in freshwater environs (Perdicaris, ; Thomas, Kavlekar, & LokaBharathi, ). As filter feeders (Mehbub et al., ), they not only consume microorganisms and organic particles but also produce potent chemicals as a defense mechanism against competitors, predators, and infectious microorganisms (Gomes Filho et al., ). These chemical entities have proven to be important to the pharmaceutical industry due to their antitumor, antimicrobial, antiviral, and cytotoxic properties (Jensen & Fenical, ; Wang, ).…”

Section: Introductionmentioning

confidence: 99%

Identification and bioactive potential of marine microorganisms from selected Florida coastal areas

Christensen

Martin

2017

MicrobiologyOpen

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The ocean, with its rich untapped chemical biodiversity, continues to serve as a source of potentially new therapeutic agents. The evaluation of the diversity of cultivable microorganisms from the marine sponge Halichondria panicea and ocean sediment samples were examined and their potential as sources of antimicrobial and antiproliferative agents were investigated. The marine sponge and sediments were collected at different depths (0.9–6 meters) and locations in Florida, including Florida Keys, Port St. Joe in Pensacola, Pensacola Bay, Pensacola Beach, and Fort Pickens. Twenty‐one cultivatable isolates were grouped according to their morphology and identified using 16S rRNA molecular taxonomy. The bacterial community identified consisted of members belonging to the Actinobacteria, Bacteroidetes, Proteobacteria (Alpha‐ and Gamma‐classes) and Firmicutes phylogeny. Seven of the microbes exhibited mild to significant cytotoxic activities against five microbial indicators but no significant cytotoxic activities were observed against the pancreatic (PANC‐1) nor the multidrug‐resistant ovarian cancer cell lines (NCI/ADR). This work reaffirms the phyla Actinobacteria and Proteobacteria as sources of potential bioactive natural product candidates for drug discovery and development.

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“…Recently, a review covered the properties and biological activities of 17 marine sponge lectins [ 36 ]. We now provide a full coverage of the 39 lectins isolated from sponges, ranging from their purification, biochemical properties to their physiological roles and biotechnological potential.…”

Section: Introductionmentioning

confidence: 99%

Porifera Lectins: Diversity, Physiological Roles and Biotechnological Potential

et al. 2015

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An overview on the diversity of 39 lectins from the phylum Porifera is presented, including 38 lectins, which were identified from the class of demosponges, and one lectin from the class of hexactinellida. Their purification from crude extracts was mainly performed by using affinity chromatography and gel filtration techniques. Other protocols were also developed in order to collect and study sponge lectins, including screening of sponge genomes and expression in heterologous bacterial systems. The characterization of the lectins was performed by Edman degradation or mass spectrometry. Regarding their physiological roles, sponge lectins showed to be involved in morphogenesis and cell interaction, biomineralization and spiculogenesis, as well as host defense mechanisms and potentially in the association between the sponge and its microorganisms. In addition, these lectins exhibited a broad range of bioactivities, including modulation of inflammatory response, antimicrobial and cytotoxic activities, as well as anticancer and neuromodulatory activity. In view of their potential pharmacological applications, sponge lectins constitute promising molecules of biotechnological interest.

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Marine Sponge Lectins: Actual Status on Properties and Biological Activities

Cited by 17 publications

References 34 publications

Cytotoxic Compounds Derived from Marine Sponges. A Review (2010–2012)

Cytotoxic Compounds Derived from Marine Sponges. A Review (2010–2012)

Identification and bioactive potential of marine microorganisms from selected Florida coastal areas

Porifera Lectins: Diversity, Physiological Roles and Biotechnological Potential

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