Marine polysaccharides: green and recyclable resources as wound dressings

Jing, Xiaodong; Sun, Yanzhen; Hu, Hao

doi:10.1039/d1qm00561h

Cited by 35 publications

(14 citation statements)

References 168 publications

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“…In the last decades, the dry membrane, scaffolds, fibers, and hydrogels of chitin/chitosan in wound healing applications have been explored, and their mechanisms have been analyzed in vitro and in vivo [ 55 , 80 , 139 , 140 , 141 , 142 ]. Nevertheless, the finely distributed nanostructures and open porous network of aerogels of chitin and chitosan will be a new class of porous materials for this field of application (examples are listed in Table 2 ).…”

Section: Production Of Polysaccharide-based Chitin/chitosan Aerogel M...mentioning

confidence: 99%

Improving Polysaccharide-Based Chitin/Chitosan-Aerogel Materials by Learning from Genetics and Molecular Biology

Behr

Ganesan

2022

Materials

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Improved wound healing of burnt skin and skin lesions, as well as medical implants and replacement products, requires the support of synthetical matrices. Yet, producing synthetic biocompatible matrices that exhibit specialized flexibility, stability, and biodegradability is challenging. Synthetic chitin/chitosan matrices may provide the desired advantages for producing specialized grafts but must be modified to improve their properties. Synthetic chitin/chitosan hydrogel and aerogel techniques provide the advantages for improvement with a bioinspired view adapted from the natural molecular toolbox. To this end, animal genetics provide deep knowledge into which molecular key factors decisively influence the properties of natural chitin matrices. The genetically identified proteins and enzymes control chitin matrix assembly, architecture, and degradation. Combining synthetic chitin matrices with critical biological factors may point to the future direction with engineering materials of specific properties for biomedical applications such as burned skin or skin blistering and extensive lesions due to genetic diseases.

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Section: Production Of Polysaccharide-based Chitin/chitosan Aerogel M...mentioning

confidence: 99%

Improving Polysaccharide-Based Chitin/Chitosan-Aerogel Materials by Learning from Genetics and Molecular Biology

Behr

Ganesan

2022

Materials

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“…In the last few decades, marine polysaccharides from algae have gained considerable attention from the fundamental research and practical biomedical applications owing to their inherent (bio)physicochemical characteristics, such as favorable biocompatibility and biodegradability, remarkable bioactivity, as well as outstanding structural functionalities ( Bilal and Iqbal, 2020 ; Zheng et al, 2020 ; He et al, 2021 ; Jing et al, 2021 ; Yang et al, 2021 ). In particular, fucoidan is a water-soluble fucose-based sulfated polysaccharide, which has remarkable multiple bioactivities, including antioxidant, antimicrobial, antithrombotic, anticoagulant, anti-inflammatory, antifibrotic, immunomodulatory, and antitumor functions ( Lin et al, 2020a ; Apostolova et al, 2020 ; Etman et al, 2020 ; Hao et al, 2020 ; Zhu et al, 2021a ; Hao et al, 2021 ; Zheng et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

A Transcriptome Sequencing Study on Genome-Wide Gene Expression Differences of Lung Cancer Cells Modulated by Fucoidan

Zhao

Zhang

et al. 2022

Front. Bioeng. Biotechnol.

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Fucoidan has received increasing attention in anti-(lung) tumors. However, the effect of fucoidan on the gene changes of lung cancer cells (LCCs) has not been examined systematically. Herein, we investigate the effect of fucoidan on the phenotypes of LCCs and their gene expression by transcriptome sequencing analysis. The phenotypes of LCCs are significantly inhibited by fucoidan. Importantly, compared to LCCs, 1 mg/ml fucoidan has no effect on the phenotypes of normal cells. Further, 6,930 differentially expressed genes (DEGs) in the transcriptome of LCCs (3,501 up-regulated and 3,429 down-regulated genes) are detected via RNA-sequencing between the fucoidan and control groups. Gene Ontology analysis confirms that DEGs are reflected in DNA replication, cell-substrate junction, regulation of cell cycle phase transition, apoptosis, focal adhesion, cadherin binding, and cell adhesion molecule binding. Thus, our findings on the transcriptomic level highlight the therapeutic potential of fucoidan for lung cancer treatment.

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“…EPS can Microbial polysaccharides find their applications in a wide range of non-food products and industrial purposes. In recent years, significant progress has been made in discovering and developing new bacterial polysaccharides with novel functional properties [30]. For example, microbial EPS promotes aggregation of soil particles, benefiting plants by keeping moisture in the environment and trapping nutrients [31].…”

Section: Introductionmentioning

confidence: 99%

Structural Characterisation and Assessment of the Novel Bacillus amyloliquefaciens RK3 Exopolysaccharide on the Improvement of Cognitive Function in Alzheimer’s Disease Mice

et al. 2021

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In this study Bacillus amyloliquefaciens RK3 was isolated from a sugar mill effluent-contaminated soil and utilised to generate a potential polysaccharide with anti-Alzheimer’s activity. Traditional and molecular methods were used to validate the strain. The polysaccharide produced by B. amyloliquefaciens RK3 was purified, and the yield was estimated to be 10.35 gL−1. Following purification, the polysaccharide was structurally and chemically analysed. The structural analysis revealed the polysaccharide consists of α-d-mannopyranose (α-d-Manp) and β-d-galactopyranose (β-d-Galp) monosaccharide units connected through glycosidic linkages (i.e, β-d-Galp(1→6)β-d-Galp (1→6)β-d-Galp(1→2)β-d-Galp(1→2)[β-d-Galp(1→6)]β-d-Galp(1→2)α-d-Manp(1→6)α-d-Manp (1→6)α-d-Manp(1→6)α-d-Manp(1→6)α-d-Manp). The scanning electron microscopy and energy-dispersive X-ray spectroscopy imaging of polysaccharides emphasise their compactness and branching in the usual tubular heteropolysaccharide structure. The purified exopolysaccharide significantly impacted the plaques formed by the amyloid proteins during Alzheimer’s disease. Further, the results also highlighted the potential applicability of exopolysaccharide in various industrial and pharmaceutical applications.

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Marine polysaccharides: green and recyclable resources as wound dressings

Abstract: As a green and renewable resource, marine polysaccharides have inherent nontoxicity, good biocompatibility, biodegradability, and environmental friendliness. Compared to land-based polysaccharides, marine polysaccharides occupy an absolute advantage in the process...

Cited by 35 publications

References 168 publications

Improving Polysaccharide-Based Chitin/Chitosan-Aerogel Materials by Learning from Genetics and Molecular Biology

Improving Polysaccharide-Based Chitin/Chitosan-Aerogel Materials by Learning from Genetics and Molecular Biology

A Transcriptome Sequencing Study on Genome-Wide Gene Expression Differences of Lung Cancer Cells Modulated by Fucoidan

Structural Characterisation and Assessment of the Novel Bacillus amyloliquefaciens RK3 Exopolysaccharide on the Improvement of Cognitive Function in Alzheimer’s Disease Mice

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