Marine pharmacology in 2005–6: Marine compounds with anthelmintic, antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of action

Abstract

BACKGROUND-The review presents the 2005-2006 peer-reviewed marine pharmacology literature, and follows a similar format to the authors' 1998-2004 reviews. The preclinical pharmacology of chemically characterized marine compounds isolated from marine animals, algae, fungi and bacteria is systematically presented.RESULTS-Anthelminthic, antibacterial, anticoagulant, antifungal, antimalarial, antiprotozoal, antituberculosis and antiviral activities were reported for 78 marine chemicals. Additionally 47 marine compounds were reported to affect the cardiovascular, immune and nervous system as well as possess anti-inflammatory effects. Finally, 58 marine compounds were shown to bind to a variety of molecular targets, and thus could potentially contribute to several pharmacological classes. SIGNIFICANCE-Continued preclinical and clinical research with marine natural products demonstrating a broad spectrum of pharmacological activity and will probably result in novel therapeutic agents for the treatment of multiple disease categories. CONCLUSIONS-Marine

Bioactivity of seagrass against the dengue fever mosquito Aedes aegypti larvae

“…The evidence for the use of marine flora to be precise in treatment of human aliments is extensive. In Asian maritime areas, seagrass are used as curative agents for various maladies such as anti malarial [11,12,20] , antibacterial [16,17] , antihelmintic, cough, antipyretic, wound healing, treatment of gallstone and goiter [24][25][26][27][28][29][30][31][32] . The studies on seaweed extracts with larvicidal activities are too restricted.…”

“…After treatment, symptoms in treated larvae were observed and recorded immediately at different time intervals and no food was offered to the larvae at this time. The larvae were considered dead if, at the end of 24 h, showed no sign of swimming movements even after gentle touching with a glass rod, as described in the World Health Organization's technical report series. Each experiment was conducted with three replicates and a concurrent control group.…”

The antimicrobial peptide Ci-MAM-A24 is highly active against multidrug-resistant and anaerobic bacteria pathogenic for humans

“…In particular, marine organisms are an inexhaustible source of novel bioactive and antimicrobial compounds, including various peptides [4,5]. We recently described two new families of putative AMPs originating from the haemocytes of a marine invertebrate, the tunicate Ciona intestinalis [6,7].…”

Ultrasound-Assisted Extraction of Antimicrobial Compounds from Thymus daenensis and Silybum marianum and Investigation of its in Presence and Without of Natural Silver Nanoparticles

“…A major challenge for health care industry that encourage researchers to overcome this limitation [10][11][12][13][14][15][16][17][18][19][20]. Plants source usability in medicine was recognized as main or complimentary medicinal products [21][22][23]. Plants of labiate family traditionally applied for treatment of exhaustion, weakness, depression, memory enhancement, circulation improvement, strengthening of fragile blood vessels [24] inflammation, infection [25] indigestion and gastritis [26].…”