Marine Peptides as Anticancer Agents: A Remedy to Mankind by Nature

Negi, Beena; Kumar, Deepak; Rawat, Diwan S.

doi:10.2174/1389203717666160724200849

Cited by 48 publications

(31 citation statements)

References 146 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Despite the complexity in cultivating and identifying bioactive metabolites from marine-derived microorganisms, it has been a valuable source for a tremendous number of diverse therapeutic compounds due to the biodiversity of the marine environment [3,24]. In our previous work, we reported two compounds, which showed antiproliferative activities against human cancer cell lines, from a strain of Aspergillus collected from marine-submerged decaying wood [16].…”

Section: Discussionmentioning

confidence: 99%

Antitumor Activity of Asperphenin A, a Lipopeptidyl Benzophenone from Marine-Derived Aspergillus sp. Fungus, by Inhibiting Tubulin Polymerization in Colon Cancer Cells

et al. 2020

View full text Add to dashboard Cite

Marine-derived microorganisms are a valuable source of novel bioactive natural products. Asperphenin A is a lipopeptidyl benzophenone metabolite isolated from large-scale cultivation of marine-derived Aspergillus sp. fungus. The compound has shown potent antiproliferative activity against various cancer cells. However, the underlying mechanism of action remained to be elucidated. In this study, we demonstrated the antitumor activity and molecular mechanism of asperphenin A in human colon cancer cells for the first time. Asperphenin A inhibited the growth of colon cancer cells through G2/M cell cycle arrest followed by apoptosis. We further discovered that asperphenin A can trigger microtubule disassembly. In addition to its effect on cell cycle, asperphenin A-induced reactive oxygen species. The compound suppressed the growth of tumors in a colon cancer xenograft model without any overt toxicity and exhibited a combination effect with irinotecan, a topoisomerase I inhibitor. Moreover, we identified the aryl ketone as a key component in the molecular structure responsible for the biological activity of asperphenin A using its synthetic derivatives. Collectively, this study has revealed the antiproliferative and antitumor mechanism of asperphenin A and suggested its possibility as a chemotherapeutic agent and lead compound with a novel structure.

show abstract

Section: Discussionmentioning

confidence: 99%

Antitumor Activity of Asperphenin A, a Lipopeptidyl Benzophenone from Marine-Derived Aspergillus sp. Fungus, by Inhibiting Tubulin Polymerization in Colon Cancer Cells

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In the course of evolution, host defence peptides and proteins developed in various organisms, such as bacteria [ 138 ], fungi [ 139 ], plants [ 140 ], animals [ 138 , 141 ] and human [ 142 ]. Some substances exhibit the multifunctional activity, for example, antimicrobial and antitumor properties [ 51 , 84 , 140 , 143 , 144 ].…”

Section: Final Remarksmentioning

confidence: 99%

Anticancer Activity of Bacterial Proteins and Peptides

2018

View full text Add to dashboard Cite

Despite much progress in the diagnosis and treatment of cancer, tumour diseases constitute one of the main reasons of deaths worldwide. The side effects of chemotherapy and drug resistance of some cancer types belong to the significant current therapeutic problems. Hence, searching for new anticancer substances and medicines are very important. Among them, bacterial proteins and peptides are a promising group of bioactive compounds and potential anticancer drugs. Some of them, including anticancer antibiotics (actinomycin D, bleomycin, doxorubicin, mitomycin C) and diphtheria toxin, are already used in the cancer treatment, while other substances are in clinical trials (e.g., p28, arginine deiminase ADI) or tested in in vitro research. This review shows the current literature data regarding the anticancer activity of proteins and peptides originated from bacteria: antibiotics, bacteriocins, enzymes, nonribosomal peptides (NRPs), toxins and others such as azurin, p28, Entap and Pep27anal2. The special attention was paid to the still poorly understood active substances obtained from the marine sediment bacteria. In total, 37 chemical compounds or groups of compounds with antitumor properties have been described in the present article.

show abstract

“…The amino acids (leucine and phenylalanine) in cluster (b) are known to occur both in the free-state and as basic units of proteins and other metabolites (peptides) in marine organisms such as sponges and associated bacteria. Marine amino acid derivatives and peptides have been shown to possess interesting biological properties; in particular, they have attracted much attention due to their high specificity against cancer cell lines [ 27 ]. 3-HQA in cluster (c) is found in several bisintercalator natural products of marine origin (such as thiocoraline, triostin, SW-163 and echinomycin/quinomycin) [ 28 ], as one of the two key chromophores (together with quinoxalinic acid) for binding to duplex DNA by insertion between the bases to allow proper placement of the peptidic core into the DNA minor groove [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluating the Effects of an Organic Extract from the Mediterranean Sponge Geodia cydonium on Human Breast Cancer Cell Lines

Costantini

Guerriero

Teta

et al. 2017

IJMS

View full text Add to dashboard Cite

Abstract:Marine sponges are an excellent source of bioactive secondary metabolites for pharmacological applications. In the present study, we evaluated the chemistry, cytotoxicity and metabolomics of an organic extract from the Mediterranean marine sponge Geodia cydonium, collected in coastal waters of the Gulf of Naples. We identified an active fraction able to block proliferation of breast cancer cell lines MCF-7, MDA-MB231, and MDA-MB468 and to induce cellular apoptosis, whereas it was inactive on normal breast cells (MCF-10A). Metabolomic studies showed that this active fraction was able to interfere with amino acid metabolism, as well as to modulate glycolysis and glycosphingolipid metabolic pathways. In addition, the evaluation of the cytokinome profile on the polar fractions of three treated breast cancer cell lines (compared to untreated cells) demonstrated that this fraction induced a slight anti-inflammatory effect. Finally, the chemical entities present in this fraction were analyzed by liquid chromatography high resolution mass spectrometry combined with molecular networking.

show abstract

Marine Peptides as Anticancer Agents: A Remedy to Mankind by Nature

Abstract: With the interdisciplinary and collaborative research and technical advancements we can search more promising and affordable anticancer drugs in future.

Cited by 48 publications

References 146 publications

Antitumor Activity of Asperphenin A, a Lipopeptidyl Benzophenone from Marine-Derived Aspergillus sp. Fungus, by Inhibiting Tubulin Polymerization in Colon Cancer Cells

Antitumor Activity of Asperphenin A, a Lipopeptidyl Benzophenone from Marine-Derived Aspergillus sp. Fungus, by Inhibiting Tubulin Polymerization in Colon Cancer Cells

Anticancer Activity of Bacterial Proteins and Peptides

Evaluating the Effects of an Organic Extract from the Mediterranean Sponge Geodia cydonium on Human Breast Cancer Cell Lines

Contact Info

Product

Resources

About