Marine organisms as a source of natural matrix for bone tissue engineering

Lalzawmliana, V.; Anand, Akrity; Mukherjee, Prasenjit; Chaudhuri, Sutapa; Kundu, Biswanath; Nandi, Samit Kumar; Thakur, Narsinh L.

doi:10.1016/j.ceramint.2018.10.108

Cited by 45 publications

(25 citation statements)

References 171 publications

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“…10 Therefore, research on HAp has been progressing exponentially to seek the possibilities of use of HAp as a bone replacement material. 10 Concurrently, researchers are also using various procedures for the improvement of mechanical, biocompatibility, and electrical properties of thus-prepared biological HAp. 11,12 HAp promotes bone ingrowths when used in orthopedic, prosthetic, and dental implant applications.…”

Section: Introductionmentioning

confidence: 99%

Structure of Apatite Nanoparticles Derived from Marine Animal (Crab) Shells: An Environment-Friendly and Cost-Effective Novel Approach to Recycle Seafood Waste

et al. 2019

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In the present investigation, crab shells as seafood wastes were successfully recycled into an extremely useful biomaterial by the thermal treatment method. Thermogravimetric-differential thermal analysis studies concluded that the calcination temperature must be beyond ∼570 °C to get a fine and crystalline apatite powder from the crab shells. Thus, the calcination temperature is taken to be 700 °C. Powder X-ray diffraction analysis of the calcined crab shells revealed hydroxyapatite (HAp)/carbonated HAp (CHAp) with an average crystallite size of 24.4 nm. Scanning electron microscopy revealed the surface morphology of the crab shells-derived apatite powder as needle-like nanorods of HAp of diameter ≈ 100–300 nm and nanospheres of CHAp of diameter ≈ 100–500. Energy-dispersive X-ray spectroscopy showed the presence of calcium, phosphorous, magnesium, and oxygen as major elements in the apatite constituents. Fourier transform infrared as well as Raman spectroscopies confirmed the formation of apatite powder. X-ray photoelectron spectroscopy results indicated the electronic environment and oxidation states of the constituent elements, Ca, C, and P. On the basis of the results obtained from various characterization techniques, the overall study emphasized an environment-friendly and cost-effective approach for recycling of the bio-pollutant and synthesis of ultra-fine, ultra-crystalline apatite-based excellent biomaterial derived from crab shells as seafood wastes with its application as a futuristic biomaterial in bone/teeth implants.

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Section: Introductionmentioning

confidence: 99%

Structure of Apatite Nanoparticles Derived from Marine Animal (Crab) Shells: An Environment-Friendly and Cost-Effective Novel Approach to Recycle Seafood Waste

et al. 2019

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“…Definite requisites for the development of ideal natural polymer-derived bioengineered scaffolds include the high porosity with huge specific surface area, appropriate distribution of pore size, designable surface chemistry sufficient structural integrity, and controllable biodegradability with degradation rate closely matching the rate of new tissue formation. Moreover, the engineered scaffold should be biocompatible, non-toxic, and have the ability to positively interact with cells to stimulate cell adhesion, migration, proliferation, and distinguished cell functionalities [58,59]. Fucoidan helps in mineral deposition in the bone matrix by increasing the expression of type-I collagen, osteocalcin, and the activity of alkaline phosphatase enzyme [60].…”

Section: Tissue-engineering Aspectsmentioning

confidence: 99%

Marine Seaweed Polysaccharides-Based Engineered Cues for the Modern Biomedical Sector

Bilal

Iqbal

2019

Marine Drugs

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Seaweed-derived polysaccharides with unique structural and functional entities have gained special research attention in the current medical sector. Seaweed polysaccharides have been or being used to engineer novel cues with biomedical values to tackle in practice the limitations of counterparts which have become ineffective for 21st-century settings. The inherited features of seaweed polysaccharides, such as those of a biologically tunable, biocompatible, biodegradable, renewable, and non-toxic nature, urge researchers to use them to design therapeutically effective, efficient, controlled delivery, patient-compliant, and age-compliant drug delivery platforms. Based on their significant retention capabilities, tunable active units, swelling, and colloidal features, seaweed polysaccharides have appeared as highly useful materials for modulating drug-delivery and tissue-engineering systems. This paper presents a standard methodological approach to review the literature using inclusion-exclusion criteria, which is mostly ignored in the reported literature. Following that, numerous marine-based seaweed polysaccharides are discussed with suitable examples. For the applied perspectives, part of the review is focused on the biomedical values, i.e., targeted drug delivery, wound-curative potential, anticancer potentialities, tissue-engineering aspects, and ultraviolet (UV) protectant potential of seaweed polysaccharides based engineered cues. Finally, current challenges, gaps, and future perspectives have been included in this review.

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“…The dentistry field must also be considered where, again aging, genetic factors, incorrect oral hygiene, or oral trauma, influence the appearance of periodontitis and caries which, at the same time, will contribute to the increase of partial or total edentulism incidence, including alveolar bone resorption. All these bone alterations require the use of grafts to promote functional tissue recovery [12]. This high demand of bone tissue implies over two million of bone grafting procedures performed annually worldwide [13] with an estimated global market of $2.6B [14].…”

Section: Bone Grafts: Limitations Of Auto and Allograftsmentioning

confidence: 99%

Current Stage of Marine Ceramic Grafts for 3D Bone Tissue Regeneration

et al. 2019

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Bioceramic scaffolds are crucial in tissue engineering for bone regeneration. They usually provide hierarchical porosity, bioactivity, and mechanical support supplying osteoconductive properties and allowing for 3D cell culture. In the case of age-related diseases such as osteoarthritis and osteoporosis, or other bone alterations as alveolar bone resorption or spinal fractures, functional tissue recovery usually requires the use of grafts. These bone grafts or bone void fillers are usually based on porous calcium phosphate grains which, once disposed into the bone defect, act as scaffolds by incorporating, to their own porosity, the intergranular one. Despite their routine use in traumatology and dental applications, specific graft requirements such as osteoinductivity or balanced dissolution rate are still not completely fulfilled. Marine origin bioceramics research opens the possibility to find new sources of bone grafts given the wide diversity of marine materials still largely unexplored. The interest in this field has also been urged by the limitations of synthetic or mammalian-derived grafts already in use and broadly investigated. The present review covers the current stage of major marine origin bioceramic grafts for bone tissue regeneration and their promising properties. Both products already available on the market and those in preclinical phases are included. To understand their clear contribution to the field, the main clinical requirements and the current available biological-derived ceramic grafts with their advantages and limitations have been collected.

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Marine organisms as a source of natural matrix for bone tissue engineering

Cited by 45 publications

References 171 publications

Structure of Apatite Nanoparticles Derived from Marine Animal (Crab) Shells: An Environment-Friendly and Cost-Effective Novel Approach to Recycle Seafood Waste

Structure of Apatite Nanoparticles Derived from Marine Animal (Crab) Shells: An Environment-Friendly and Cost-Effective Novel Approach to Recycle Seafood Waste

Marine Seaweed Polysaccharides-Based Engineered Cues for the Modern Biomedical Sector

Current Stage of Marine Ceramic Grafts for 3D Bone Tissue Regeneration

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