Marine oils: metabolic effects and role in human nutrition

Sanders, Tom

doi:10.1079/pns19930086

Cited by 47 publications

(19 citation statements)

References 90 publications

(69 reference statements)

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“…The possible uses of EPA in the prevention of cardiovascular diseases (e.g. atherosclerosis, thrombogenesis) and to inhibit tumor growth and inflammation have been reported (Dyerberg et al, 1978;Hirai et al, 1989;Kinsella et al, 1990;Sanders, 1993). The main source of EPA in the human diet is marine fish (Sukenik et al, 1994).…”

Section: Introductionmentioning

confidence: 98%

Accumulation of eicosapentaenoic acid in Nannochloropsis sp. in response to elevated CO2 concentrations

et al. 2005

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To increase eicosapentaenoic acid (EPA, 20:5, n-3) content in the marine alga Nannochloropsis sp., the effect of CO 2 concentration during cultivation has been investigated. In a batch culture under normal atmospheric conditions (0.037% CO 2 ), the EPA content per cell increased during the first 1.5 days and then decreased immediately even though the cells were in an exponential growth phase. Increasing the CO 2 concentration to 0.3% and 2% over day 1.5 retained the EPA content at the higher concentration for another 1 and 2 days, respectively, suggesting that the EPA accumulation is enhanced by elevated concentrations of CO 2 . EPA accumulation in response to elevated CO 2 concentrations was also observed during a later growth phase when CO 2 was introduced after the decrease of EPA content. The addition of CO 2 caused a slight decrease in the pH of the medium though this was not the cause of the observed EPA accumulation as addition of acidic buffer did not affect the EPA content. The maximum EPA production was obtained when 2% CO 2 was supplied 12 h prior to the end of the exponential growth. The total EPA production during 4-day cultivation was about twice that obtained with ambient air. These results suggest that the available CO 2 concentration affects the EPA content in Nannochloropsis sp.

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Section: Introductionmentioning

confidence: 98%

Accumulation of eicosapentaenoic acid in Nannochloropsis sp. in response to elevated CO2 concentrations

et al. 2005

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“…Although not attempted previously, it was considered here that such fatty material might retain diagnostic dietary information, since the FA composition of human tissues is highly representative of the distribution of FAs in the diet Summers et al, 2000;Valero-Garrido et al, 1990). Thus, human reliance on marine diets, which are naturally enriched in long-chain monounsaturated (MUFAs, C 20:1 FA and C 22:1 FA ) and polyunsaturated FAs (PUFAs; C 20:5 FA , n-3, C 22:6 FA , n-3), results in their elevated abundance in plasma relative to individuals consuming average Western diets (Dyerberg et al, 1975;Goh et al, 1997;Imaichi et al, 1963;Roche, 1999;Sanders, 1993), a pattern which might be reflected in the lipid composition of the individual.…”

Section: Introductionmentioning

confidence: 99%

Probing dietary change of the Kwädąy Dän Ts'ìnchį individual, an ancient glacier body from British Columbia: I. Complementary use of marine lipid biomarker and carbon isotope signatures as novel indicators of a marine diet

Corr

Richards

Jim

et al. 2008

Journal of Archaeological Science

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“…The increases in DHA proportion affected all treated subjects with the exception of one subject who had had the highest baseline values. It may be suggested that the enhancement of plasma DHA concentrations by eating designer eggs could result in bene®cial effects on various health-related parameters such as cardiovascular function, in¯ammation and immunocompetence (Sanders, 1993;Uauy et al, 1999).…”

Section: Fatty Acidsmentioning

confidence: 99%

Designer egg evaluation in a controlled trial

Surai¹,

Macpherson²,

Speake³

et al. 2000

Eur J Clin Nutr

118

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Objective: To evaluate the ability of designer eggs enriched in vitamin E, lutein, selenium (Se) and docosahexaenoic acid (DHA) to deliver micronutrients to the human in a palatable and visually acceptable form. Design: Double-blind, placebo-controlled trial, two treatment groups balanced for sex and age. Setting: Department of Biochemistry and Nutrition, SAC, Scotland. Subjects: Forty healthy adult volunteers completed the study. Volunteers were recruited among staff of the Scottish Agricultural College Interventions: Volunteers consumed, for 8 weeks, either a designer egg or a normal table egg per day. Fasting blood samples were taken before and at the end of the study. Results: Consumption of designer eggs enriched in vitamin E, lutein, Se and DHA signi®cantly increased the levels of a-tocopherol, lutein and DHA in plasma as compared to the changes found after consumption of normal table eggs, with the largest increases found in plasma lutein (1.88-fold increase). The proportion of DHA was increased in all the main lipid classes of the plasma including triacylglycerol (2.3-fold), free fatty acids (1.6-fold), cholesteryl ester (1.4-fold) and phospholipid (1.3-fold). Egg consumption did not change Se concentration in plasma, blood pressure, total plasma lipid concentrations or the concentrations of total cholesterol and HDLcholesterol in plasma. Conclusion; Consumption of designer eggs enriched in vitamin E, lutein, DHA and Se as part of normal diet for 8 weeks effectively increased the blood levels of a-tocopherol, lutein and DHA.

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Marine oils: metabolic effects and role in human nutrition

Cited by 47 publications

References 90 publications

Accumulation of eicosapentaenoic acid in Nannochloropsis sp. in response to elevated CO2 concentrations

Accumulation of eicosapentaenoic acid in Nannochloropsis sp. in response to elevated CO2 concentrations

Probing dietary change of the Kwädąy Dän Ts'ìnchį individual, an ancient glacier body from British Columbia: I. Complementary use of marine lipid biomarker and carbon isotope signatures as novel indicators of a marine diet

Designer egg evaluation in a controlled trial

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