Marine natural products

Faulkner, D. John

doi:10.1039/np9900700269

Cited by 156 publications

(58 citation statements)

References 85 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The polyplacophorans (chitons) are essentially algal grazers on shallow rocky reefs and the Scaphopoda (tusk shells) are Table 1. Published research on secondary metabolites from the different classes of Mollusca, complied from Faulkner (1984aFaulkner ( , b, 1986Faulkner ( , 1987Faulkner ( , 1988Faulkner ( , 1990Faulkner ( , 1991Faulkner ( , 1992bFaulkner ( , 1993Faulkner ( , 1994Faulkner ( , 1995Faulkner ( , 1996Faulkner ( , 1997Faulkner ( , 1998Faulkner ( , 1999Faulkner ( , 2000Faulkner ( , 2001Faulkner ( , 2002, Blunt et al, (2003, 2007, 2008, 2009), Alam & Thomson (1998), Baker & Murphy (1976, 1981 and additional searches using Chemical Abstracts, Biological Abstracts and Medline. The number of species that have been subject to natural products studies is provided, in addition to the number of compounds isolated and the number of research papers, accounting for overlap between the different literature sources.…”

Section: (1) Molluscan Biological Diversitymentioning

confidence: 99%

“…Prior to this, Baker & Murphy (1976, 1981 compiled information on 148 molluscan metabolites in their two-volume book 'Compounds from Marine Organisms'. Faulkner (1984aFaulkner ( , b, 1986Faulkner ( , 1987Faulkner ( , 1988Faulkner ( , 1990Faulkner ( , 1991Faulkner ( , 1992Faulkner ( , 1993Faulkner ( , 1994bFaulkner ( , 1995Faulkner ( , 1996Faulkner ( , 1997Faulkner ( , 1998Faulkner ( , 1999Faulkner ( , 2000Faulkner ( , 2001Faulkner ( , 2002 included molluscs in his annual review of marine natural products, reporting a total of 729 compounds from 199 species. These reviews have been continued in recent years by Blunt et al (2003Blunt et al ( , 2004Blunt et al ( , 2005Blunt et al ( , 2006Blunt et al ( , 2007Blunt et al ( , 2008Blunt et al ( , 2009) reporting a further 190 distinct compounds from 75 species.…”

Section: (1) Molluscan Biological Diversitymentioning

confidence: 99%

“…5) and the taxonomic distribution of the metabolites (Figs 6, 7). Taking into consideration the chemical redundancy between species, at least 977 distinct compounds have been isolated from just 251 species in the annual reviews of marine natural products (Faulkner 1984a(Faulkner , b, 1986(Faulkner , 1987(Faulkner , 1988(Faulkner , 1990(Faulkner , 1991(Faulkner , 1992b(Faulkner , 1993(Faulkner , 1994(Faulkner , 1995(Faulkner , 1996(Faulkner , 1997(Faulkner , 1998(Faulkner , 1999(Faulkner , 2000(Faulkner , 2001(Faulkner , 2002Blunt et al, 2003Blunt et al, , 2004Blunt et al, , 2005Blunt et al, , 2006Blunt et al, , 2007Blunt et al, , 2008Blunt et al, , 2009. Similarly, Alam & Thomson (1998) report 585 compounds from just 135 species of marine molluscs.…”

Section: (1) Molluscan Biological Diversitymentioning

confidence: 99%

See 2 more Smart Citations

Molluscan biological and chemical diversity: secondary metabolites and medicinal resources produced by marine molluscs

2010

View full text Add to dashboard Cite

The phylum Mollusca represents an enormous diversity of species with eight distinct classes. This review provides a taxonomic breakdown of the published research on marine molluscan natural products and the medicinal products currently derived from molluscs, in order to identify priority targets and strategies for future research. Some marine gastropods and bivalves have been of great interest to natural products chemists, yielding a diversity of chemical classes and several drug leads currently in clinical trials. Molluscs also feature prominently in a broad range of traditional natural medicines, although the active ingredients in the taxa involved are typically unknown. Overall secondary metabolites have only been investigated from a tiny proportion (<1%) of molluscan species. At the class level, the number of species subject to chemical studies mirrors species richness and our relative knowledge of the biology of different taxa. The majority of molluscan natural products research is focused within one of the major groups of gastropods, the opisthobranchs (a subgroup of Heterobranchia), which are primarily comprised of soft-bodied marine molluscs. Conversely, most molluscan medicines are derived from shelled gastropods and bivalves. The complete disregard for several minor classes of molluscs is unjustified based on their evolutionary history and unique life styles, which may have led to novel pathways for secondary metabolism. The Polyplacophora, in particular, have been identified as worthy of future investigation given their use in traditional South African medicines and their abundance in littoral ecosystems. As bioactive compounds are not always constitutively expressed in molluscs, future research should be targeted towards biosynthetic organs and inducible defence reactions for specific medicinal applications. Given the lack of an acquired immune system, the use of bioactive secondary metabolites is likely to be ubiquitous throughout the Mollusca and broadening the search field may uncover interesting novel chemistry.

show abstract

Section: (1) Molluscan Biological Diversitymentioning

confidence: 99%

Section: (1) Molluscan Biological Diversitymentioning

confidence: 99%

Section: (1) Molluscan Biological Diversitymentioning

confidence: 99%

See 1 more Smart Citation

Molluscan biological and chemical diversity: secondary metabolites and medicinal resources produced by marine molluscs

2010

View full text Add to dashboard Cite

show abstract

“…Marine organisms are potentially prolific sources of highly bioactive secondary metabolites that might represent useful leads in the development of new pharmaceutical agents (Iwamoto et al, 1998;Iwamoto et al, 1999;Iwamoto et al, 2001). During the last four decades, numerous novel compounds have been isolated from marine organisms and many of these substances have been demonstrated to possess interesting biological activ-ities (Faulkner, 1984a(Faulkner, ,b, 1986(Faulkner, , 1987(Faulkner, , 1988(Faulkner, , 1990(Faulkner, , 1991(Faulkner, , 1992(Faulkner, , 1993(Faulkner, , 1994(Faulkner, , 1995(Faulkner, , 1996(Faulkner, , 1997(Faulkner, , 1998(Faulkner, , 1999(Faulkner, , 2000(Faulkner, , 2001(Faulkner, , 2002.…”

Section: Introductionmentioning

confidence: 99%

Biological importance of marine algae

Gamal

2010

Saudi Pharmaceutical Journal

393

166

View full text Add to dashboard Cite

Marine organisms are potentially prolific sources of highly bioactive secondary metabolites that might represent useful leads in the development of new pharmaceutical agents. Algae can be classified into two main groups; first one is the microalgae, which includes blue green algae, dinoflagellates, bacillariophyta (diatoms)… etc., and second one is macroalgae (seaweeds) which includes green, brown and red algae. The microalgae phyla have been recognized to provide chemical and pharmacological novelty and diversity. Moreover, microalgae are considered as the actual producers of some highly bioactive compounds found in marine resources. Red algae are considered as the most important source of many biologically active metabolites in comparison to other algal classes. Seaweeds are used for great number of application by man. The principal use of seaweeds as a source of human food and as a source of gums (phycocollides). Phycocolloides like agar agar, alginic acid and carrageenan are primarily constituents of brown and red algal cell walls and are widely used in industry.

show abstract

“…The research in natural compounds, which is continually expanding and is of enormous interest, explores new compounds coming from different sources, among which the sea could be considered as an almost infinite source of natural resources, some of which have important therapeutic potential [49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,105,106,107,108,109,110…”

Section: Introductionmentioning

confidence: 99%

Synthetic Strategies to Terpene Quinones/Hydroquinones

Gordaliza

2012

Marine Drugs

View full text Add to dashboard Cite

The cytotoxic and antiproliferative properties of many natural sesquiterpene-quinones and -hydroquinones from sponges offer promising opportunities for the development of new drugs. A review dealing with different strategies for obtaining bioactive terpenyl quinones/hydroquinones is presented. The different synthetic approches for the preparation of the most relevant quinones/hydroquinones are described.

show abstract

Marine natural products

Cited by 156 publications

References 85 publications

Molluscan biological and chemical diversity: secondary metabolites and medicinal resources produced by marine molluscs

Molluscan biological and chemical diversity: secondary metabolites and medicinal resources produced by marine molluscs

Biological importance of marine algae

Synthetic Strategies to Terpene Quinones/Hydroquinones

Contact Info

Product

Resources

About