Marine Natural Products as Lead Anti-HIV Agents

Gochfeld, Deborah J.; Sayed, Khalid A. El; Yousaf, Muhammad; Hu, Ji-Qiang; Bartyzel, Piotr; Dunbar, D. Chuck; Wilkins, Sian; Zjawiony, Jordan K.; Schinazi, R. F.; Wirtz, Susan Schlueter

doi:10.2174/1389557033487962

Cited by 53 publications

(35 citation statements)

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“…9-O-2-methylbenzoylisoaaptamine (3)-Brownish amorphous solid; 1 H and 13 C NMR (CDCl 3 ) data see Table 5; ESI-MS m/z 347 (M + , 100). High resolution EI-MS calculated for C 21 …”

Section: Generalmentioning

confidence: 99%

Modification at the C9 position of the marine natural product isoaaptamine and the impact on HIV-1, mycobacterial, and tumor cell activity

Gul

Hammond

Yousaf

et al. 2006

Bioorganic & Medicinal Chemistry

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“…9-O-2-methylbenzoylisoaaptamine (3)-Brownish amorphous solid; 1 H and 13 C NMR (CDCl 3 ) data see Table 5; ESI-MS m/z 347 (M + , 100). High resolution EI-MS calculated for C 21 …”

Section: Generalmentioning

confidence: 99%

Modification at the C9 position of the marine natural product isoaaptamine and the impact on HIV-1, mycobacterial, and tumor cell activity

Gul

Hammond

Yousaf

et al. 2006

Bioorganic & Medicinal Chemistry

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“…The theopalauamide is correlated with both anti-HIV and anti-tumor activities [20,47,54]. The theopalauamide is targeted by mevalonate pyrophosphate decarboxylase, an enzyme involved in ergosterol biosynthesis, and this shows that theopalauamide directly interacts with ergosterol.…”

Section: Anti-hiv Peptides From the Lithistidmentioning

confidence: 98%

Lithistid Sponges Derived Compounds and Their Importance in Biological Research - A Review

Abirla

2018

Asian J Pharm Clin Res

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Lithistid sponges have an important source of complex natural compounds with biological activities. The lithistid sponges are of interest to biomedical science because of the great variety of pharmaceutically relevant biological activities of their chemical extracts and are considered as economically important. The compounds identified in these sponges have therapeutic potential and have been frequently hypothesized to contain compounds of bacterial origin. The peptides identified from these lithistid sponges are found to be the sources of antifungal activity. The active agents of these sponges also have cytotoxic and immunosuppressive activities. Many of the cyclic peptides of lithistid represent the anti-HIV activity. The different structure and biological activities of the compounds derived from these sponges have more chemical aspects too.

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“…Interestingly, cytarabine (Cytostar-U) also known as Ara-C, a compound isolated from the Caribbean sponge Cryptotheca crypta currently being used with other anticancer drugs in the treatment of acute myelocytic leukaemia (AML) [4]. In addition to potential anticancer applications, the bioactive compounds of sponges have a myriad of activities ranging from antibiotic activity including anticoagulant, antithrombin, anti-inflammatory HIV-protease inhibitory, HIV reverse transcriptase inhibitory, as well as imunomodulatory activities [5].…”

Section: Marine Invertebratesmentioning

confidence: 99%

Marine Organisms as Biomedical Resources Enrich Quality of Life

Somavarapu¹

2017

CBB

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Abstract:The Ocean, called the 'mother of origin of life', is a rich source of biological and chemical diversity. Marine floras include microflora (bacteria, actinobacteria, cyanobacteria and fungi), microalgae, macroalgae (seaweeds), and flowering plants (mangroves and other halophytes). Marine organisms have unique properties as they are exposed to extreme marine environmental conditions. This vast marine floral resource offer a great way for discovery of new drugs which can fight deadly diseases like cancer, acquired immune deficiency syndrome (AIDS), arthritis, etc. Sea has got plenty of metabolites and other resources in living or dead form. Thermo-stable proteases, lipases, esterases, and starch and xylan degrading enzymes have been actively sought from bacterial and archaeal hyperthermophilic marine microorganisms. Marine cyanobacteria appear to be potential sources for production of vitamins such as B complex group and vitamin-E. The carotenoids and phycobiliprotein pigments of cyanobacteria have commercial value as natural food colouring agents, as feed additives, as enhancers of the color of egg yolks, to improve the health and fertility of cattle, as drugs and in the cosmetic industries. Some anti-HIV activity has been observed with the compounds extracted from Lyngbya lagerhaimanii and Phormidium tenue. Thus an attempt to review few marine derived biomedical resources was done emphasizing that with the advent of modern technologies it is anticipated that the marine environment will become an invaluable source of novel compounds in the future.

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Marine Natural Products as Lead Anti-HIV Agents

Cited by 53 publications

References 1 publication

Modification at the C9 position of the marine natural product isoaaptamine and the impact on HIV-1, mycobacterial, and tumor cell activity

Modification at the C9 position of the marine natural product isoaaptamine and the impact on HIV-1, mycobacterial, and tumor cell activity

Lithistid Sponges Derived Compounds and Their Importance in Biological Research - A Review

Marine Organisms as Biomedical Resources Enrich Quality of Life

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