Marine Natural Products as Anticancer Agents

Alves, Celso; Diederich, Marc

doi:10.3390/md19080447

Cited by 15 publications

(11 citation statements)

References 16 publications

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“…Information is scant on the use of marine peptides to treat this malignancy [ 5 , 6 , 118 ]. Marine peptides have been shown to have multiple anticancer effects.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

“…Treatments have been impacted by marine-based medicines, with anticancer treatments made available with several marine chemical compounds. Indeed, clinical approval has been granted for several such treatments, including belantamabmafodotin, cytarabine, enfortumabvedotin, brentuximab vedotin, eribulin mesylate, lurbinectedin, fludarabine phosphate (prodrug of ara-A), nelarabine (prodrug of ara-G), polatuzumabvedotin, trabectedin, vidarabine, and plitidepsin [ 6 , 7 , 8 , 9 ]. Improvement in the physiological state of cancer patients depends on the introduction of natural strategies for clinical treatment.…”

Section: Introductionmentioning

confidence: 99%

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Therapeutic Potential of Marine Peptides in Prostate Cancer: Mechanistic Insights

et al. 2022

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Prostate cancer (PCa) is the leading cause of cancer death in men, and its treatment is commonly associated with severe adverse effects. Thus, new treatment modalities are required. In this context, natural compounds have been widely explored for their anti-PCa properties. Aquatic organisms contain numerous potential medications. Anticancer peptides are less toxic to normal cells and provide an efficacious treatment approach via multiple mechanisms, including altered cell viability, apoptosis, cell migration/invasion, suppression of angiogenesis and microtubule balance disturbances. This review sheds light on marine peptides as efficacious and safe therapeutic agents for PCa.

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“…Information is scant on the use of marine peptides to treat this malignancy [ 5 , 6 , 118 ]. Marine peptides have been shown to have multiple anticancer effects.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Therapeutic Potential of Marine Peptides in Prostate Cancer: Mechanistic Insights

et al. 2022

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“…19,20 Numerous bioactive compounds from marine organisms show various therapeutic effects and pharmacological properties, such as antioxidant, antitumour, anticancer, and antiviral. [21][22][23] More than 36,000 marine-derived compounds have been reported, and over 1,500 compounds more are delineated each year. 24 There are many marine-derived compounds in preclinical, clinical pipeline, and some marine-derived compounds have been put on the market.…”

Section: Introductionmentioning

confidence: 99%

Carrageenan: Future Potential Ingredient of Lubricant and Feminine Hygiene Product with Possible Protection Effects against HPV Infection

Jumardi

Arfah

Permatasari

2023

Kemija U Industriji

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The discovery that human papillomavirus (HPV) infection is the primary cause of cervical cancer has opened up new avenues for prevention. Carrageenans are attractive candidates for developing potential HPV prevention due to their actions against a wide range of viruses, mainly through the blocking of the viral attachment stage. In addition, they are characterised by low production costs, abundant availability, biodegradability, biocompatibility, and non-toxicity. This review presents an overview of in vitro and in vivo studies of carrageenan antiviral properties, availability, and future liquid-sexual material. Based on the results of previous studies, both in vitro and in vivo carrageenan has the potential to be applied as a lubricant and feminine cleanser because it can reduce HPV infection, is non-toxic, and non-allergenic.

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“…The application of metal-based drugs is often limited due to their drawbacks such as neurotoxicity, nephrotoxicity as well as ototoxicity [13,14]. The researchers put a great effort in finding potential anticancer drugs based on natural ucts [15][16][17][18][19][20]. It is well known that polyphenolic compounds, widespread in the plan dom, are archetypal antioxidants and may reduce the risk of many inflammatory cancer) and degenerative diseases [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Anticancer Potential of Xanthohumol and Isoxanthohumol Loaded into SBA-15 Mesoporous Silica Particles against B16F10 Melanoma Cells

et al. 2022

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Xanthohumol (XN) and isoxanthohumol (IXN), prenylated flavonoids from Humulus lupulus, have been shown to possess antitumor/cancerprotective, antioxidant, antiinflammatory, and antiangiogenic properties. In this study, mesoporous silica (SBA-15) was loaded with different amounts of xanthohumol and isoxanthohumol and characterized by standard analytical methods. The anticancer potential of XN and IXN loaded into SBA-15 has been evaluated against malignant mouse melanoma B16F10 cells. When these cells were treated with SBA-15 containing xanthohumol, an increase of the activity correlated with a higher immobilization rate of XN was observed. Considering the amount of XN loaded into SBA-15 (calculated from TGA), an improved antitumor potential of XN was observed (IC50 = 10.8 ± 0.4 and 11.8 ± 0.5 µM for SBA-15|XN2 and SBA-15|XN3, respectively; vs. IC50 = 18.5 ± 1.5 µM for free XN). The main mechanism against tumor cells of immobilized XN includes inhibition of proliferation and autophagic cell death. The MC50 values for SBA-15 loaded with isoxanthohumol were over 300 µg/mL in all cases investigated.

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Marine Natural Products as Anticancer Agents

Abstract: Cancer remains one of the major threats to human health and one of the deadliest diseases worldwide [...]

Cited by 15 publications

References 16 publications

Therapeutic Potential of Marine Peptides in Prostate Cancer: Mechanistic Insights

Therapeutic Potential of Marine Peptides in Prostate Cancer: Mechanistic Insights

Carrageenan: Future Potential Ingredient of Lubricant and Feminine Hygiene Product with Possible Protection Effects against HPV Infection

Anticancer Potential of Xanthohumol and Isoxanthohumol Loaded into SBA-15 Mesoporous Silica Particles against B16F10 Melanoma Cells

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