Marine Natural Products — a Vital Source of Novel Biotherapeutics

Investigating the Antiviral Therapeutic Potentialities of Marine Polycyclic Lamellarin Pyrrole Alkaloids as Promising Inhibitors for SARS-CoV-2 and Zika Main Proteases (Mpro)

“…Since 1950's, marine natural products (MNPs) and their synthetic analogues have been emerged as a revolutionary chemical space which possess unprecedented diversification of molecular articturings with novel therapeutic actions [50][51][52]. Up to date, 17 marine derived natural products have been clinically approved as effective medications for numerous challenging diseases, whilst further 20 marine molecules are currently being investigated and developed within different clinical and preclinical phases [53][54][55].…”

Marine Biotherapeutics: Delving Into The Vast Untapped Resource Of Therapeutic Molecules Showing Better Outcomes Against Diseases

“…In this review paper, we would like to introduce few very important and effective roles of marine extracted products or compounds. FDA (Food and Drug Administration) and EU (European Union) has also recently approved MNPs (Begum & Hemalatha, 2022) such as Cytarabine, which was clinically approved as a potential drug in 1969 as Ara-C type of compound which is effective against leukaemia and has saved many lives and is till date widely used for the treatment of the disease. Later, in the year 1976, a compound called Vidarabine, isolated from sponge Tethya crypta, which is Ara-A type of compound that encompasses antiviral bioactivity (Sagar et al, 2010).…”

“…Basal CRP levels were reduced and the exercise-induced CRP response was attenuated in those individuals who regularly had omega 3 fatty acid supplement (Hansen et al, 2021).Trabectidin, approved as anticancer drug in 2007which was isolated from Caribbean marine tunicate Ecteinascidia turbinate (Senthilkumar & Kim, 2013) and Plitidepsin have grabbed the attention for cancer treatment. These drugs are of marine origin that have a positive effect working as an antitumour agent by not only targeting the tumour cells but also the tumour environment (Galmarini et al, 2014), EribulinMesylate (2010), Brentunimabvedotin (2011) and Iota-carrageenan are some other studied MNPs (Begum & Hemalatha, 2022). MNPs have been isolated from various resources have demonstrated a wide range of pharmacological properties including antibacterial, antiviral, analgesic, anticancer, apoptotic, antiangiogenic and antioxidant properties (Begum & Hemalatha, 2022).…”

“…These drugs are of marine origin that have a positive effect working as an antitumour agent by not only targeting the tumour cells but also the tumour environment (Galmarini et al, 2014), EribulinMesylate (2010), Brentunimabvedotin (2011) and Iota-carrageenan are some other studied MNPs (Begum & Hemalatha, 2022). MNPs have been isolated from various resources have demonstrated a wide range of pharmacological properties including antibacterial, antiviral, analgesic, anticancer, apoptotic, antiangiogenic and antioxidant properties (Begum & Hemalatha, 2022). Marine Bacillus species have been studied that produce Mixirins that possess cytotoxic activity against colon cancerous cells in humans.…”

Anticancer and Neuroprotective Effects of the Triterpene Glycosides From Sea Cucumber Holothuria imitans

“…6 In this sense, MNPs have shown an immense potential in the treatment of human illnesses; in fact, evidence demonstrates the antiviral, antitumoral and anti-inflammatory effects of these compounds, in addition to improve the immune function. 7,8 In fact, There are various marine organisms which are sources of MNPs, nevertheless the phylum Echinodermata is the one of the most significant sources; and inside this, the sea cucumbers from the class Holothuroidea, are one of the major sources of glycosylated compounds. 9 Generally, Sea cucumber glycosides have attracted special interest due to their cancer preventive and immunomodulatory properties.…”