Marine Natural Product Bis-indole Alkaloid Caulerpin: Chemistry and Biology

Lunagariya, Jignesh; Bhadja, Poonam; Zhong, Shenghui; Vekariya, Rohit L.; Xu, Shi‐Hai

doi:10.2174/1389557517666170927154231

Cited by 46 publications

(28 citation statements)

References 60 publications

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“…Algae extracts of the genus Caulerpa are rich in caulerpin (37), an indolic alkaloid with proven anti-inflammatory activity. Caulerpin has been described in different species of the genus Caulerpa, such as Caulerpa peltata, Caulerpa racemosa, Caulerpa cupressoides, Caulerpa paspaloides, Caulerpa prolifera, C. sertularioides, C. mexicana, and Caulerpa lentillifera, besides being found in the red algae Chondria armata [95]. The analysis of C. peltata and C. racemosa ethanolic extracts showed caulerpin as one of the main products [96,97].…”

Section: Anti-inflammatory Alkaloids In Marine Algaementioning

confidence: 99%

Marine Alkaloids with Anti-Inflammatory Activity: Current Knowledge and Future Perspectives

2020

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Alkaloids are nitrogenous compounds with various biological activities. Alkaloids with anti-inflammatory activity are commonly found in terrestrial plants, but there are few records of the identification and characterization of the activity of these compounds in marine organisms such as fungi, bacteria, sponges, ascidians, and cnidarians. Seaweed are a source of several already elucidated bioactive compounds, but few studies have described and characterized the activity of seaweed alkaloids with anti-inflammatory properties. In this review, we have gathered the current knowledge about marine alkaloids with anti-inflammatory activity and suggest future perspectives for the study and bioprospecting of these compounds.

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Section: Anti-inflammatory Alkaloids In Marine Algaementioning

confidence: 99%

Marine Alkaloids with Anti-Inflammatory Activity: Current Knowledge and Future Perspectives

2020

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“…Indole alkaloids have exhibited a wide array of biological activities and the frameworks produced by marine species are often very different from those produced by terrestrial species [ 159 , 160 , 161 ]. One interesting example is the bisindole caulerpin or caulerpine 53 ( Figure 6 ), isolated mainly from green algae genus Caulerpa [ 161 , 162 ] but also from Codium decorticatum (Woodward) M. Howe [ 163 ] and Halimeda incrassata (J. Ellis) J.V. Lamouroux [ 164 ].…”

Section: Secondary Metabolites From Seaweeds With In Vitro Cytotoxmentioning

confidence: 99%

Seaweed Secondary Metabolites In Vitro and In Vivo Anticancer Activity

2018

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Isolation, finding or discovery of novel anticancer agents is very important for cancer treatment, and seaweeds are one of the largest producers of chemically active metabolites with valuable cytotoxic properties, and therefore can be used as new chemotherapeutic agents or source of inspiration to develop new ones. Identification of the more potent and selective anticancer components isolated from brown, green and red seaweeds, as well as studies of their mode of action is very attractive and constitute a small but relevant progress for pharmacological applications. Several researchers have carried out in vitro and in vivo studies in various cell lines and have disclosed the active metabolites among the terpenoids, including carotenoids, polyphenols and alkaloids that can be found in seaweeds. In this review the type of metabolites and their cytotoxic or antiproliferative effects will be discussed additionally their mode of action, structure-activity relationship and selectivity will also be revealed. The diterpene dictyolactone, the sterol cholest-5-en-3β,7α-diol and the halogenated monoterpene halomon are among the reported compounds, the ones that present sub-micromolar cytotoxicity. Additionally, one dimeric sesquiterpene of the cyclolaurane-type, three bromophenols and one halogenated monoterpene should be emphasized because they exhibit half maximal inhibitory concentration (IC50) values between 1–5 µM against several cell lines.

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“…Caulerpin (isolated and purified from the lipid extract of Caulerpa racemose) (Lunagariya et al, 2017) possesses comparable analgesic activity (0.0945 μmol) in contrast to dypirone (0.0426 μmol) by reducing acetic-acid-induced nociception in the abdominal constriction test.…”

Section: Antinociceptive and Antiinflammatory Activitiesmentioning

confidence: 99%