Marine n-3 polyunsaturated fatty acids affect the blood pressure control in patients with newly diagnosed hypertension – a 1-year follow-up study

Bagge, Carina Nørskov; Strandhave, Charlotte; Skov, Charlotte Mose; Svensson, My; Schmidt, Erik Berg; Christensen, Jeppe Hagstrup

doi:10.1016/j.nutres.2017.02.009

Cited by 8 publications

(4 citation statements)

References 41 publications

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“…However, preformed TMAO (found in fish) is more readily metabolized than TMAO that is synthesized from its precursors, thus fish-based TMAO is more readily available, and urinary TMAO itself has been identified as a good biomarker of fish intake ( 23 , 67 ). Given the reported beneficial health effects of fish consumption ( 68 , 69 ), time-dependent analyses of TMAO concentrations in both urine and plasma linked to robust dietary and metabolic data may be important to stratify individuals with high TMAO concentrations/high TMAO-production capacity by differential metabolic/dietary status, as has been previously performed ( 21 , 46 ).…”

Section: Discussionmentioning

confidence: 99%

Plasma Trimethylamine N-Oxide and Its Precursors: Population Epidemiology, Parent–Child Concordance, and Associations with Reported Dietary Intake in 11- to 12-Year-Old Children and Their Parents

Andraos

Lange

Clifford

et al. 2020

Current Developments in Nutrition

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Abstract Background Trimethylamine N-oxide (TMAO) is a microbiome- and diet-derived metabolite implicated in adverse cardiovascular outcomes. To date, studies of plasma TMAO concentrations have largely focused on individuals with metabolic disease. As such, data on TMAO concentrations in population settings and parent–child dyads are lacking. Objectives This study aimed to investigate parent–child concordance, age, and sex effects on plasma concentrations of TMAO and its precursors [l-carnitine, choline, betaine, and dimethylglycine (DMG)]. Associations between concentrations of TMAO and its precursors and self-reported dietary intakes of animal protein (i.e., red meat, meat products, chicken, fish, milk products, and cheese) and fast-food meals were also investigated. Methods A total of 1166 children (mean ± SD age: 11 ± 0.5 y, 51% female) and 1324 parents (mean ± SD age: 44 ± 5.1 y, 87% female) had a biomedical assessment as part of Growing Up in Australia's Child Health Checkpoint. Plasma TMAO and precursor concentrations were quantified using ultra-high-pressure LC coupled with tandem MS. Results Familial dyads significantly contributed to plasma TMAO and precursor concentrations (P < 0.0001), explaining 37% of variance for TMAO concentrations. Least-square mean ± SE plasma TMAO was lower in children (0.79 ± 0.02 µM on the log-scale) than in adults (1.22 ± 0.02 µM). By contrast, children's betaine (40.30 ± 0.34 µM) and DMG concentrations (1.02 ± 0.01 µM on the log-scale) were higher than adults’ betaine (37.50 ± 0.32 µM) and DMG concentrations (0.80 ± 0.01 µM) (P < 0.0001). Mean values of all metabolites, except adult TMAO, were higher in males than in females (P < 0.001). Greater reported intake of red meat and fish was associated with higher TMAO concentrations in both children [estimates (95% CIs) for red meat: 0.06 (0.01, 0.10); fish: 0.11 (0.06, 0.17)] and adults [red meat: 0.13 (0.08, 0.17); meat products: 0.07 (0.03, 0.12); and fish: 0.09 (0.04, 0.14)]. Conclusions Age, sex, and shared family factors, including diet, contribute to variation in plasma concentrations of TMAO and its precursors.

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Section: Discussionmentioning

confidence: 99%

Plasma Trimethylamine N-Oxide and Its Precursors: Population Epidemiology, Parent–Child Concordance, and Associations with Reported Dietary Intake in 11- to 12-Year-Old Children and Their Parents

Andraos

Lange

Clifford

et al. 2020

Current Developments in Nutrition

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“…Long-chain n -3 PUFA from marine foods demonstrate BP-lowering effects [6]. Clinical studies show that long-chain n -3 PUFA consumption diminishes the risk of cardiac death, potentially through regulation of triglycerides, heart rate and BP [7].…”

Section: Introductionmentioning

confidence: 99%

Long-Chain Polyunsaturated Fatty Acids Are Associated with Blood Pressure and Hypertension over 10-Years in Black South African Adults Undergoing Nutritional Transition

Zec

Schutte

Ricci

et al. 2019

Foods

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Nutritional transition in Africa is linked with increased blood pressure (BP). We examined 10-year fatty acid status and longitudinal associations between individual long-chain polyunsaturated fatty acids (PUFA), BP and status of hypertension (≥140/90 mmHg and/or medication use) in black South Africans. We included 300 adults (>30 years) participating in the Prospective Urban Rural Epidemiology study, and analysed data from three consecutive examinations (2005, 2010 and 2015 study years). Fatty acids in plasma phospholipids were analysed by gas chromatography-mass spectrometry. We applied sequential linear mixed models for continuous outcomes and generalized mixed models for the hypertension outcome, in the complete sample and separately in urban and rural subjects. Mean baseline systolic/diastolic BP was 137/89 mmHg. Ten-year hypertension status increased among rural (48.6% to 68.6%, p = 0.001) and tended to decrease among urban subjects (67.5% to 61.9%, p = 0.253). Regardless of urbanisation, n-6 PUFA increased and eicosapentaenoic acid (EPA, C20:5 n-3) decreased over the 10-years. Subjects in the highest tertile of arachidonic acid (C20:4 n-6) had 3.81 mmHg lower systolic (95% confidence interval (CI): −7.07, −0.54) and 3.82 mmHg lower diastolic BP (DBP) (95% CI: −5.70, −1.95) compared to the reference tertile, irrespective of lifestyle and clinical confounders. Similarly, osbond acid (C22:5 n-6) was inversely associated with DBP. Over the 10-years, subjects in the highest EPA tertile presented with +2.92 and +1.94 mmHg higher SBP and DBP, respectively, and with 1.46 higher odds of being hypertensive. In black South African adults, individual plasma n-6 PUFA were inversely associated with BP, whereas EPA was adversely associated with hypertension, supporting implementation of dietary fat quality in national cardiovascular primary prevention strategies.

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“…The total of EPA + DHA accounts 19.67 g/100 g lipid , which represents 1 g/100 g in fillet. These results indicate that the species is interesting from a nutritional point of view since consumption of long chain PUFAs has been widely related to beneficial effects in human health (Bagge et al., 2017).…”

Section: Resultsmentioning

confidence: 89%

Cold smoking of Lebranche mullet (Mugil liza): Physicochemical, sensory, and microbiological evaluation

Lugo

Agustinelli

Yeannes

et al. 2020

Food sci. technol. int.

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The suitability of Mugil liza for cold smoking was evaluated and the effect of four different salting treatments on physicochemical, microbiological, and sensory characteristics was assessed. The addition of sucrose (3%) and acetic acid (0.5%) to the brine lead to fillet dehydration with lower NaCl penetration, combined with higher reduction of pH. Brining at refrigerated temperature (5 ± 1 ℃) instead of room temperature (16 ± 2 ℃) was more effective in preventing microbial growth. Loads of bacterial groups assessed in all smoked samples were below 100 CFU/g and the aw, moisture, NaCl, and pH values achieved were within the typical stability range of smoked fish products. The obtained products were characterized by the smoked aroma and salty taste, differing in 7 of the 21 evaluated descriptors. The use of acetic acid in brine formulation showed an effect over color and texture descriptors. The affective test indicated the overall acceptability of products, being preferred the samples treated in the lowest NaCl concentration (5%).

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Marine n-3 polyunsaturated fatty acids affect the blood pressure control in patients with newly diagnosed hypertension – a 1-year follow-up study

Cited by 8 publications

References 41 publications

Plasma Trimethylamine N-Oxide and Its Precursors: Population Epidemiology, Parent–Child Concordance, and Associations with Reported Dietary Intake in 11- to 12-Year-Old Children and Their Parents

Plasma Trimethylamine N-Oxide and Its Precursors: Population Epidemiology, Parent–Child Concordance, and Associations with Reported Dietary Intake in 11- to 12-Year-Old Children and Their Parents

Long-Chain Polyunsaturated Fatty Acids Are Associated with Blood Pressure and Hypertension over 10-Years in Black South African Adults Undergoing Nutritional Transition

Cold smoking of Lebranche mullet (Mugil liza): Physicochemical, sensory, and microbiological evaluation

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