Marine n-3 Polyunsaturated Fatty Acid Supplementation and Quality of Life After Kidney Transplant

Aasebø, Willy; Svensson, My; Jenssen, Trond; Eide, Ivar

doi:10.1016/j.transproceed.2019.01.067

Cited by 3 publications

(2 citation statements)

References 12 publications

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“…This might also explain the outcome of three more recent studies. Patients were treated with a delay of 6 to 8 weeks [ 168 , 169 ] post transplantation or immediately after transplantation but only for a few days [ 20 ]. These studies could neither observe protective effects on renal function [ 20 , 168 ] nor on quality of life [ 169 ].…”

Section: Omega-3 Polyunsaturated Fatty Acidsmentioning

confidence: 99%

“…Patients were treated with a delay of 6 to 8 weeks [ 168 , 169 ] post transplantation or immediately after transplantation but only for a few days [ 20 ]. These studies could neither observe protective effects on renal function [ 20 , 168 ] nor on quality of life [ 169 ]. Indeed, a study administering n-3 PUFA immediately after transplantation for a longer period found raised blood levels of EPA/DHA which were correlated with reduced events of rejection.…”

Section: Omega-3 Polyunsaturated Fatty Acidsmentioning

confidence: 99%

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Combating Ischemia-Reperfusion Injury with Micronutrients and Natural Compounds during Solid Organ Transplantation: Data of Clinical Trials and Lessons of Preclinical Findings

Mauerhofer

Grumet

Schemmer

et al. 2021

IJMS

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Although extended donor criteria grafts bear a higher risk of complications such as graft dysfunction, the exceeding demand requires to extent the pool of potential donors. The risk of complications is highly associated with ischemia-reperfusion injury, a condition characterized by high loads of oxidative stress exceeding antioxidative defense mechanisms. The antioxidative properties, along with other beneficial effects like anti-inflammatory, antiapoptotic or antiarrhythmic effects of several micronutrients and natural compounds, have recently emerged increasing research interest resulting in various preclinical and clinical studies. Preclinical studies reported about ameliorated oxidative stress and inflammatory status, resulting in improved graft survival. Although the majority of clinical studies confirmed these results, reporting about improved recovery and superior organ function, others failed to do so. Yet, only a limited number of micronutrients and natural compounds have been investigated in a (large) clinical trial. Despite some ambiguous clinical results and modest clinical data availability, the vast majority of convincing animal and in vitro data, along with low cost and easy availability, encourage the conductance of future clinical trials. These should implement insights gained from animal data.

show abstract

Section: Omega-3 Polyunsaturated Fatty Acidsmentioning

confidence: 99%

Section: Omega-3 Polyunsaturated Fatty Acidsmentioning

confidence: 99%

Combating Ischemia-Reperfusion Injury with Micronutrients and Natural Compounds during Solid Organ Transplantation: Data of Clinical Trials and Lessons of Preclinical Findings

Mauerhofer

Grumet

Schemmer

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

Food and mood: healthy eating for mental health with chronic kidney disease

Jackson

2022

Journal of Kidney Care

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There is a growing interest in the connection between healthy eating, mental health (MH) chronic disease prevention. Although people with chronic kidney disease (CKD) are disproportionately affected by poor MH, nutritional guidelines have traditionally focused on non-mental factors, such as physical health, disease progression and biochemical control. Dietary manipulation, through healthy eating, may influence the gut microbiome, as well as mental and kidney health; this can be achieved through the interaction between the gut microbiome, brain and kidney, as well as the body's metabolism of nutrients, such as the amino acid tryptophan. While a wide range of nutrients are implicated in brain function and health, there is little evidence to support supplementation-based treatments–other than to avoid conventional malnutrition and micronutrient deficiencies. Whole diets such as the Mediterranean diet may benefit MH as well as reducing cardiovascular, renal and other chronic disease risk. A supportive and individualised approach to renal dietary restrictions may help to reduce the MH burden of CKD.

show abstract

Food and mood: healthy eating for mental health with chronic kidney disease

Jackson

2023

Journal of Kidney Care

View full text Add to dashboard Cite

There is a growing interest in the connection between healthy eating, mental health (MH) and chronic disease prevention. Although people with chronic kidney disease (CKD) are disproportionately affected by poor MH, nutritional guidelines have traditionally focused on non-mental factors, such as physical health, disease progression and biochemical control. Dietary manipulation, through healthy eating, may influence the gut microbiome, as well as mental and kidney health. This can be achieved through the interaction between the gut microbiome, brain and kidney, as well as the body's metabolism of nutrients, such as the amino acid tryptophan. While a wide range of nutrients are implicated in brain function and health, there is little evidence to support supplementation-based treatments–other than to avoid conventional malnutrition and micronutrient deficiencies. Whole diets, such as the Mediterranean diet, may benefit MH, as well as reducing cardiovascular, renal and other chronic disease risk. A supportive and individualised approach to renal dietary restrictions may help to reduce the MH burden of CKD.

show abstract

Marine n-3 Polyunsaturated Fatty Acid Supplementation and Quality of Life After Kidney Transplant

Cited by 3 publications

References 12 publications

Combating Ischemia-Reperfusion Injury with Micronutrients and Natural Compounds during Solid Organ Transplantation: Data of Clinical Trials and Lessons of Preclinical Findings

Combating Ischemia-Reperfusion Injury with Micronutrients and Natural Compounds during Solid Organ Transplantation: Data of Clinical Trials and Lessons of Preclinical Findings

Food and mood: healthy eating for mental health with chronic kidney disease

Food and mood: healthy eating for mental health with chronic kidney disease

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