Marine Fungal White Biotechnology: An Ecological and Industrial Perspective

Vala, Anjana K.; Sachaniya, Bhumi K.; Dave, Bharti P.

doi:10.1007/978-3-030-10480-1_15

Cited by 4 publications

(1 citation statement)

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“…The presence of fungi in all kinds of ecosystems provides excellent opportunities for the research and discovery of new natural products [ 24 , 25 ]. Fungi-derived compounds are widely used in medical, biotechnological, and traditional bioremediation applications [ 26 , 27 , 28 , 29 ]. They have also been the subject of several studies to obtain new biomolecules and enzymes, serving various purposes such as biofuels, insecticides, pesticides, anthelmintic, and analgesics.…”

Section: Introductionmentioning

confidence: 99%

The Cytotoxic Properties of Extreme Fungi’s Bioactive Components—An Updated Metabolic and Omics Overview

Kiss

Akbari

Marchev

et al. 2023

Life

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Fungi are the most diverse living organisms on planet Earth, where their ubiquitous presence in various ecosystems offers vast potential for the research and discovery of new, naturally occurring medicinal products. Concerning human health, cancer remains one of the leading causes of mortality. While extensive research is being conducted on treatments and their efficacy in various stages of cancer, finding cytotoxic drugs that target tumor cells with no/less toxicity toward normal tissue is a significant challenge. In addition, traditional cancer treatments continue to suffer from chemical resistance. Fortunately, the cytotoxic properties of several natural products derived from various microorganisms, including fungi, are now well-established. The current review aims to extract and consolidate the findings of various scientific studies that identified fungi-derived bioactive metabolites with antitumor (anticancer) properties. The antitumor secondary metabolites identified from extremophilic and extremotolerant fungi are grouped according to their biological activity and type. It became evident that the significance of these compounds, with their medicinal properties and their potential application in cancer treatment, is tremendous. Furthermore, the utilization of omics tools, analysis, and genome mining technology to identify the novel metabolites for targeted treatments is discussed. Through this review, we tried to accentuate the invaluable importance of fungi grown in extreme environments and the necessity of innovative research in discovering naturally occurring bioactive compounds for the development of novel cancer treatments.

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