Marine Edible Algae as Disease Preventers

Gómez-Gutiérrez, C.M.; Guerra-Rivas, Graciela; Soria-Mercado, Ima Esthela; Ayala-Sánchez, Nahara

doi:10.1016/b978-0-12-387669-0.00003-x

Cited by 16 publications

(13 citation statements)

References 24 publications

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“…The American Cancer Society estimated that there would be about 219,440 new cases of lung cancer in the US in 2009, accounting for approximately 15% of all new cancer diagnoses [1]. More than 45% of all patients with incident lung cancer present with advanced disease [2]; median survival time among these patients ranges from 8 to 13 months [3].…”

Section: Introductionmentioning

confidence: 99%

Healthcare costs in patients with metastatic lung cancer receiving chemotherapy

Vera-Llonch

Weycker

Glass

et al. 2011

BMC Health Serv Res

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BackgroundTo characterize healthcare resource utilization and costs in patients with metastatic lung cancer receiving chemotherapy in the US.MethodsUsing data from a large private multi-payer health insurance claims database (2000-2006), we identified all patients beginning chemotherapy for metastatic lung cancer. Healthcare resource use (inpatient, outpatient, medications) and costs were tallied over time from date of therapy initiation ("index date") to date of disenrollment from the health plan (in most instances, presumably due to death) or the end of the study period, whichever occurred first. Healthcare utilization and costs were characterized using Kaplan-Meier sample average methods.ResultsThe study population consisted of 4068 patients; mean (SD) age was 65 (11) years. Over a median follow-up of 334 days, study subjects averaged 1.5 hospital admissions, 8.9 total inpatient days, and 69 physician office and hospital outpatient visits. Mean (95% CI) cumulative total healthcare costs were $125,849 ($120,228, $131,231). Costs of outpatient medical services and inpatient care constituted 34% and 20% of total healthcare costs, respectively; corresponding estimates for outpatient chemotherapy and other medication were 22% and 24%.ConclusionOur study sheds additional light on the burden of metastatic lung cancer among patients receiving chemotherapy, in terms of total cost thru end of life as well as component costs by setting and type of service, and may be useful in informing medical resource allocation in this patient population.

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Section: Introductionmentioning

confidence: 99%

Healthcare costs in patients with metastatic lung cancer receiving chemotherapy

Vera-Llonch

Weycker

Glass

et al. 2011

BMC Health Serv Res

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“…In addition, evidence suggests that rising levels of atmospheric CO 2 are causing major changes in marine food chains, leading to reductions in both the quantity and quality of fish for human consumption (Rossoll et al, 2012;Garzke et al, 2016;Golden et al, 2016). These effects may also involve alterations in the amounts and compositions of marine algae consumed by fish (Gomez-Gutierrez et al, 2011).…”

Section: Impacts On Fisheriesmentioning

confidence: 99%

Nutritional ecology: understanding the intersection of climate/environmental change, food systems and health.

Raiten

Combs²

2019

Agriculture for Improved Nutrition: Seizing the Momentum

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“…They are also good sources of dietary fiber, polyunsaturated fatty acids, minerals, vitamins and a wide range of phenolic compounds [2,3]. Marine brown algae include a wide range of edible seaweeds such as Laminaria spp., Undaria spp., Ecklonia spp., Sargassum spp., Fucus spp., etc., which are rich in a specific group of antioxidant compounds, the phlorotannins [1,4,5]. Phlorotannins are unique phenolic compounds that belong to a large class of marine secondary metabolites exclusively produced by brown algae.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Cytoprotective Activities of Fucus spiralis Seaweed on a Human Cell in Vitro Model

Pintéus

Silva

Alves

et al. 2017

IJMS

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Antioxidants play an important role as Reactive Oxygen Species (ROS) chelating agents and, therefore, the screening for potent antioxidants from natural sources as potential protective agents is of great relevance. The main aim of this study was to obtain antioxidant-enriched fractions from the common seaweed Fucus spiralis and evaluate their activity and efficiency in protecting human cells (MCF-7 cells) on an oxidative stress condition induced by H2O2. Five fractions, F1–F5, were obtained by reversed-phase vacuum liquid chromatography. F3, F4 and F5 revealed the highest phlorotannin content, also showing the strongest antioxidant effects. The cell death induced by H2O2 was reduced by all fractions following the potency order F4 > F2 > F3 > F5 > F1. Only fraction F4 completely inhibited the H2O2 effect. To understand the possible mechanisms of action of these fractions, the cellular production of H2O2, the mitochondrial membrane potential and the caspase 9 activity were studied. Fractions F3 and F4 presented the highest reduction on H2O2 cell production. All fractions decreased both caspase-9 activity and cell membrane depolarization (except F1). Taken all together, the edible F. spiralis reveal that they provide protection against oxidative stress induced by H2O2 on the human MCF-7 cellular model, probably acting as upstream blockers of apoptosis.

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Marine Edible Algae as Disease Preventers

Cited by 16 publications

References 24 publications

Healthcare costs in patients with metastatic lung cancer receiving chemotherapy

Healthcare costs in patients with metastatic lung cancer receiving chemotherapy

Nutritional ecology: understanding the intersection of climate/environmental change, food systems and health.

Antioxidant and Cytoprotective Activities of Fucus spiralis Seaweed on a Human Cell in Vitro Model

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