Marine-derived n-3 fatty acids therapy for stroke

Campano, Celia Gabriela Alvarez; MacLeod, Mary Joan; Aucott, Lorna; Thiès, Frank

doi:10.1002/14651858.cd012815.pub2

Cited by 6 publications

(2 citation statements)

References 201 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The presence of EPA in the network was striking because it was connected with many florae. Many studies ( Nakase et al., 2015 ; Aung et al., 2018 ; Alvarez Campano et al., 2019 ) have shown that EPA supplementation can improve the prognosis of patients and prevent cardiovascular and cerebrovascular diseases. Therefore, increased EPA levels might lead to good outcomes after stroke.…”

Section: Discussionmentioning

confidence: 99%

Lactulose Improves Neurological Outcomes by Repressing Harmful Bacteria and Regulating Inflammatory Reactions in Mice After Stroke

Yuan

Xin

Han

et al. 2021

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Background and ObjectiveGut microbiota dysbiosis following stroke affects the recovery of neurological function. Administration of prebiotics to counteract post-stroke dysbiosis may be a potential therapeutic strategy to improve neurological function. We aim to observe the effect of lactulose on neurological function outcomes, gut microbiota composition, and plasma metabolites in mice after stroke.MethodsMale C57BL/6 mice (20–25 g) were randomly divided into three groups: healthy control, photothrombotic stroke + triple-distilled water, and photothrombotic stroke + lactulose. After 14 consecutive days of lactulose administration, feces, plasma, and organs were collected. 16S rDNA sequencing, plasma untargeted metabolomics, qPCR, flow cytometry and Elisa were performed.ResultsLactulose supplementation significantly improved the functional outcome of stroke, downregulated inflammatory reaction, and increased anti-inflammatory factors in both the brain and gut. In addition, lactulose supplementation repaired intestinal barrier injury, improved gut microbiota dysbiosis, and partially amended metabolic disorder after stroke.ConclusionLactulose promotes functional outcomes after stroke in mice, which may be attributable to repressing harmful bacteria, and metabolic disorder, repairing gut barrier disruption, and reducing inflammatory reactions after stroke.

show abstract

Section: Discussionmentioning

confidence: 99%

Lactulose Improves Neurological Outcomes by Repressing Harmful Bacteria and Regulating Inflammatory Reactions in Mice After Stroke

Yuan

Xin

Han

et al. 2021

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

show abstract

“…Additionally, DHA and EPA have been extensively studied for their beneficial effects on neurological development and function, and these components are generally supplied to the brain and eyes predominantly from dietary sources [ 215 , 216 ]. They could prevent neuronal damage that is related to aging or neurodegenerative diseases [ 217 ].…”

Section: Marine Food Sources-derived Fatty Acid-based Nanomaterialsmentioning

confidence: 99%

Marine biomaterials in biomedical nano/micro-systems

Wang,

Chen,

Wang

et al. 2023

J Nanobiotechnol

View full text Add to dashboard Cite

Marine resources in unique marine environments provide abundant, cost-effective natural biomaterials with distinct structures, compositions, and biological activities compared to terrestrial species. These marine-derived raw materials, including polysaccharides, natural protein components, fatty acids, and marine minerals, etc., have shown great potential in preparing, stabilizing, or modifying multifunctional nano-/micro-systems and are widely applied in drug delivery, theragnostic, tissue engineering, etc. This review provides a comprehensive summary of the most current marine biomaterial-based nano-/micro-systems developed over the past three years, primarily focusing on therapeutic delivery studies and highlighting their potential to cure a variety of diseases. Specifically, we first provided a detailed introduction to the physicochemical characteristics and biological activities of natural marine biocomponents in their raw state. Furthermore, the assembly processes, potential functionalities of each building block, and a thorough evaluation of the pharmacokinetics and pharmacodynamics of advanced marine biomaterial-based systems and their effects on molecular pathophysiological processes were fully elucidated. Finally, a list of unresolved issues and pivotal challenges of marine-derived biomaterials applications, such as standardized distinction of raw materials, long-term biosafety in vivo, the feasibility of scale-up, etc., was presented. This review is expected to serve as a roadmap for fundamental research and facilitate the rational design of marine biomaterials for diverse emerging applications. Graphical Abstract

show abstract