Marine-derived bioactive compounds with anti-obesity effect: A review

Hu, Xiaoqian; Tao, Ningping; Wang, Mingfu; Xiao, Jianbo

doi:10.1016/j.jff.2015.12.006

Cited by 73 publications

(47 citation statements)

References 122 publications

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“…Obesity is the most important risk factor for metabolic diseases such as hyperlipidemia, hypertension and type 2 diabetes 28,29 . Vinegar has many physiological functions and it was reported that the acetic acid is responsible for its anti-glycemic and anti-obesity effects, and its ability to regulate lipid metabolism 30 .…”

Section: Resultsmentioning

confidence: 99%

Quantification of Fraglide-1, a New Functional Ingredient, in Vinegars

et al. 2017

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Section: Resultsmentioning

confidence: 99%

Quantification of Fraglide-1, a New Functional Ingredient, in Vinegars

et al. 2017

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“…Brown seaweeds which are known to produce bioactive pholorotannins include Eisenia bicyclis , Ecklonia cava , Ecklonia stolonifera , Undaria pinnatifida , Sargassum thunbergii , Ishigeo kamurae and Laminaria japonica [87]. Of the brown seaweeds, E. cava contains the highest amount of phlorotannins [11]. …”

Section: Algal Compounds With Anti-obesity Effectsmentioning

confidence: 99%

“…Of the phlorotannins, eckol appears to be the most promising target compound for anti-obesity drug development due to its multiple inhibitions on pancreatic lipase, adipogenesis and PTP1B [11]. However, most of the studies on phlorotannins were in vitro (cell lines and enzyme inhibitory assay).…”

Section: Algal Compounds With Anti-obesity Effectsmentioning

confidence: 99%

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Marine Algae as a Potential Source for Anti-Obesity Agents

2016

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Obesity is a major epidemic that poses a worldwide threat to human health, as it is also associated with metabolic syndrome, type 2 diabetes and cardiovascular disease. Therapeutic intervention through weight loss drugs, accompanied by diet and exercise, is one of the options for the treatment and management of obesity. However, the only approved anti-obesity drug currently available in the market is orlistat, a synthetic inhibitor of pancreatic lipase. Other anti-obesity drugs are still being evaluated at different stages of clinical trials, while some have been withdrawn due to their severe adverse effects. Thus, there is a need to look for new anti-obesity agents, especially from biological sources. Marine algae, especially seaweeds are a promising source of anti-obesity agents. Four major bioactive compounds from seaweeds which have the potential as anti-obesity agents are fucoxanthin, alginates, fucoidans and phlorotannins. The anti-obesity effects of such compounds are due to several mechanisms, which include the inhibition of lipid absorption and metabolism (e.g., fucoxanthin and fucoidans), effect on satiety feeling (e.g., alginates), and inhibition of adipocyte differentiation (e.g., fucoxanthin). Further studies, especially testing bioactive compounds in long-term human trials are required before any new anti-obesity drugs based on algal products can be developed.

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“…Marine algae, chiefly seaweeds are a potential source of a number of medicinally active compund, including anti-obesity agent 23 . Seaweed is multicellular, marine algae which can grow to up to 60 metres in length.…”

Section: Need To Look Out For Alternative Treatment Strategy Involvinmentioning

confidence: 99%

Manifestation of Metabolic Syndrome by Turbinaria Species: A Review

Mishra¹,

Kumar²,

Juyal³

et al. 2017

Int. Res. J. Pharm.

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Metabolic disorder refers to a cluster of metabolic abnormalities (i.e., insulin resistance, hypertension, dyslipidemia, obesity, high cholesterol and high blood pressure). The metabolic disorder is fast becoming a global emergency. Drugs presently available in the market help in curing the disorder only up to some extent and providing symptomatic relief, in lieu of an array of side effects, hence it is the need of the hour to look for alternative strategy for prevention and treatment of metabolic syndrome. Marine natural products are a source of antihypertensive, antihyperglycemic, antioxidative, and anticancer agents possibly useful in the treatment or in the prevention of metabolic disorders. Through this review we have made an effort to throw some light on potential uses of the marine sea weed, a genus of brown algae Turbinaria (Phaeophyceae) as a potential agent for the treatment and amelioration of metabolic syndrome and related disorder, we have briefed about various chemical constituents found in the different species of Turbinaria and the role they can play in achieving the above said goal.

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Marine-derived bioactive compounds with anti-obesity effect: A review

Cited by 73 publications

References 122 publications

Quantification of Fraglide-1, a New Functional Ingredient, in Vinegars

Quantification of Fraglide-1, a New Functional Ingredient, in Vinegars

Marine Algae as a Potential Source for Anti-Obesity Agents

Manifestation of Metabolic Syndrome by Turbinaria Species: A Review

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