Marine biotechnologies and synthetic biology, new issues for a fair and equitable profit-sharing commercial use

Bloch, Jean-François; Tardieu-Guigues, Elisabeth

doi:10.1016/j.margen.2014.07.003

Cited by 11 publications

(5 citation statements)

References 5 publications

(4 reference statements)

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“…Cyanobacteria are found in a variety of habitats (Cameron, 1962 ; Miller and Castenholz, 2000 ; Garcia-Pichel et al, 2001 ), with the most prominent ones being found in marine and freshwater environment (Reed et al, 1984 ; Nadeau and Castenholz, 2000 ; Martins et al, 2011 ). Several useful compounds from marine cyanobacteria and its commercial potential have been well documented (Bloch and Tardieu-Guigues, 2014 ). However, no systematic study has been reported comparing the alkane and/or alkene production capabilities of marine and freshwater cyanobacterial strains.…”

Section: Introductionmentioning

confidence: 99%

Heterogeneity of Alkane Chain Length in Freshwater and Marine Cyanobacteria

Shakeel

Fatma

et al. 2015

Front. Bioeng. Biotechnol.

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The potential utilization of cyanobacteria for the biological production of alkanes represents an exceptional system for the next generation of biofuels. Here, we analyzed a diverse group of freshwater and marine cyanobacterial isolates from Indian culture collections for their ability to produce both alkanes and alkenes. Among the 50 cyanobacterial isolates screened, 32 isolates; 14 freshwater and 18 marine isolates; produced predominantly alkanes. The GC-MS/MS profiles revealed a higher percentage of pentadecane and heptadecane production for marine and freshwater strains, respectively. Oscillatoria species were found to be the highest producers of alkanes. Among the freshwater isolates, Oscillatoria CCC305 produced the maximum alkane level with 0.43 μg/mg dry cell weight, while Oscillatoria formosa BDU30603 was the highest producer among the marine isolates with 0.13 μg/mg dry cell weight. Culturing these strains under different media compositions showed that the alkane chain length was not influenced by the growth medium but was rather an inherent property of the strains. Analysis of the cellular fatty acid content indicated the presence of predominantly C16 chain length fatty acids in marine strains, while the proportion of C18 chain length fatty acids increased in the majority of freshwater strains. These results correlated with alkane chain length specificity of marine and freshwater isolates indicating that alkane chain lengths may be primarily determined by the fatty acid synthesis pathway. Moreover, the phylogenetic analysis showed clustering of pentadecane-producing marine strains that was distinct from heptadecane-producing freshwater strains strongly suggesting a close association between alkane chain length and the cyanobacteria habitat.

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Section: Introductionmentioning

confidence: 99%

Heterogeneity of Alkane Chain Length in Freshwater and Marine Cyanobacteria

Shakeel

Fatma

et al. 2015

Front. Bioeng. Biotechnol.

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“…This involves codon optimization of genes of interest followed by chemical synthesis, cloning and expression in an optimized heterologous host. Although an important addition to the biodiscovery toolkit, synthetic biology brings its own challenges and many ethical issues remain to be resolved [ 148 ].…”

Section: Mining In the Informatics Eramentioning

confidence: 99%

Emerging Concepts Promising New Horizons for Marine Biodiscovery and Synthetic Biology

Reen

Gutiérrez‐Barranquero

Dobson

et al. 2015

Marine Drugs

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The vast oceans of the world, which comprise a huge variety of unique ecosystems, are emerging as a rich and relatively untapped source of novel bioactive compounds with invaluable biotechnological and pharmaceutical potential. Evidence accumulated over the last decade has revealed that the diversity of marine microorganisms is enormous with many thousands of bacterial species detected that were previously unknown. Associated with this diversity is the production of diverse repertoires of bioactive compounds ranging from peptides and enzymes to more complex secondary metabolites that have significant bioactivity and thus the potential to be exploited for innovative biotechnology. Here we review the discovery and functional potential of marine bioactive peptides such as lantibiotics, nanoantibiotics and peptidomimetics, which have received particular attention in recent years in light of their broad spectrum of bioactivity. The significance of marine peptides in cell-to-cell communication and how this may be exploited in the discovery of novel bioactivity is also explored. Finally, with the recent advances in bioinformatics and synthetic biology, it is becoming clear that the integration of these disciplines with genetic and biochemical characterization of the novel marine peptides, offers the most potential in the development of the next generation of societal solutions.

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Section: Introductionmentioning

confidence: 99%

“…Marine biotechnology (also called blue biotechnology) consists of the application of biological resources from the sea for industrial, medical or environmental purposes (Thompson et al 2017), which constitutes a precious economical sector presenting a yearly turnover of 3.93 $ together with great expectations, including many different subjects and organisms which could report benefits to the industry (Bloch and Tardieu-Guigues 2014;Thompson et al 2017). Among them, micro-and macro-algae have gained much attention as natural sources of bioactive compounds that exhibit a great applicability as dietary ingredients and other industrial processes (Bloch and Tardieu-Guigues 2014;Sudhakar et al 2018). On these bases, seaweeds have been consumed for many years in Asian countries, since they constitute a rich source of fiber, vitamins, minerals and antioxidants, thus prompting an increase in their consumption and, consequently, promoting intense efforts on the characterization of their health-enhancing properties (Cardozo et al 2007;Go ´mez-Ordo ´n ˜ez et al 2012;Cian et al 2015;Rudtanatip et al 2018;Gurpilhares et al 2019).…”

Section: Introductionmentioning

confidence: 99%

Biological properties and potential of compounds extracted from red seaweeds

et al. 2022

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Macroalgae have been recently used for different applications in the food, cosmetic and pharmaceutical industry since they do not compete for land and freshwater against other resources. Moreover, they have been highlighted as a potential source of bioactive compounds. Red algae (Rhodophyta) are the largest group of seaweeds, including around 6000 different species, thus it can be hypothesized that they are a potential source of bioactive compounds. Sulfated polysaccharides, mainly agar and carrageenans, are the most relevant and exploited compounds of red algae. Other potential molecules are essential fatty acids, phycobiliproteins, vitamins, minerals, and other secondary metabolites. All these compounds have been demonstrated to exert several biological activities, among which antioxidant, anti-inflammatory, antitumor, and antimicrobial properties can be highlighted. Nevertheless, these properties need to be further tested on in vivo experiments and go in-depth in the study of the mechanism of action of the specific molecules and the understanding of the structure–activity relation. At last, the extraction technologies are essential for the correct isolation of the molecules, in a cost-effective way, to facilitate the scale-up of the processes and their further application by the industry. This manuscript is aimed at describing the fundamental composition of red algae and their most studied biological properties to pave the way to the utilization of this underused resource.

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Marine biotechnologies and synthetic biology, new issues for a fair and equitable profit-sharing commercial use

Cited by 11 publications

References 5 publications

Heterogeneity of Alkane Chain Length in Freshwater and Marine Cyanobacteria

Heterogeneity of Alkane Chain Length in Freshwater and Marine Cyanobacteria

Emerging Concepts Promising New Horizons for Marine Biodiscovery and Synthetic Biology

Biological properties and potential of compounds extracted from red seaweeds

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