Marine Biodiversity As a Resource for Bioactive Molecules As Inhibitors of Microbial Quorum Sensing Phenotypes

Hamza, Faseela; Zinjarde, Smita

doi:10.1007/978-981-10-9026-4_16

Cited by 3 publications

(2 citation statements)

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“…These specific physiochemical characteristics of saline environments may induce halophiles to synthesize unique molecules and physiological pathways to cope with the stress conditions that characterize these habitats. In fact, halophiles have been reported to produce bioactive molecules with properties that differ from those found in non-saline habitats (reviews: [199,200,201,202]). Indeed, hypersaline environments have demonstrated to be a valuable source of microorganisms that produce a number of novel compounds such as exopolysaccharides [203,204] and enzymes, such as alpha-amylases [205], endoglucanases [206], or lipases [207] that exhibit unique properties and promising perspectives for biotechnological exploitation.…”

Section: Saline Environments As An Important Source Of Bioactive Mmentioning

confidence: 99%

“…In the same way as saline and hypersaline environments, the marine environment, based on its huge microbial biodiversity, is also considered as an important resource of novel bioactive compounds, including secondary metabolites used for pharmaceutical and biotechnological applications (reviews: [202,208,209]) and anti-QS substances (reviews: [114,202,210,211]) amongst other molecules.…”

Section: Saline Environments As An Important Source Of Bioactive Mmentioning

confidence: 99%

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Saline Environments as a Source of Potential Quorum Sensing Disruptors to Control Bacterial Infections: A Review

2019

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Saline environments, such as marine and hypersaline habitats, are widely distributed around the world. They include sea waters, saline lakes, solar salterns, or hypersaline soils. The bacteria that live in these habitats produce and develop unique bioactive molecules and physiological pathways to cope with the stress conditions generated by these environments. They have been described to produce compounds with properties that differ from those found in non-saline habitats. In the last decades, the ability to disrupt quorum-sensing (QS) intercellular communication systems has been identified in many marine organisms, including bacteria. The two main mechanisms of QS interference, i.e., quorum sensing inhibition (QSI) and quorum quenching (QQ), appear to be a more frequent phenomenon in marine aquatic environments than in soils. However, data concerning bacteria from hypersaline habitats is scarce. Salt-tolerant QSI compounds and QQ enzymes may be of interest to interfere with QS-regulated bacterial functions, including virulence, in sectors such as aquaculture or agriculture where salinity is a serious environmental issue. This review provides a global overview of the main works related to QS interruption in saline environments as well as the derived biotechnological applications.

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Section: Saline Environments As An Important Source Of Bioactive Mmentioning

confidence: 99%

Section: Saline Environments As An Important Source Of Bioactive Mmentioning

confidence: 99%

Saline Environments as a Source of Potential Quorum Sensing Disruptors to Control Bacterial Infections: A Review

2019

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Use of marine microorganisms in designing anti-infective strategies for sustainable aquaculture production

Hamza

Zinjarde

2023

Journal of Applied Microbiology

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Aquaculture, a noteworthy food production sector, is confronted with disease occurrences. Treatment of aquaculture pathogens with antibiotics is often rendered ineffective due to biofilm formation and the development of resistant strains. Marine ecosystems encompass unusual microorganisms that produce novel bioactive compounds, including agents that could be used as alternatives to antibiotics. Moreover, biomass and/or biomolecules associated with these microorganisms could act as feed supplements to enhance overall health of aquaculture species' and improve water quality parameters. The present review summarizes contents of studies on such marine microorganisms with the potential to be developed as agents for tackling bacterial diseases in the aquaculture segment. Bioactive compounds produced by marine bacteria are known to inhibit biofilm associated infections mediated by their bactericidal properties (produced by Bacillus, Vibrio, Photobacterium and Pseudoalteromonas species), surfactant activity (obtained from different species of Bacillus and Staphylococcus lentus), anti-adhesive activity (derived from Bacillus sp. and Brevibacterium sp.) and quorum sensing inhibition. Several marine fungal isolates capable of producing antibacterial agents have also been effective in inhibiting aquaculture associated pathogens. Another strategy followed by investigators to reduce severity of infections is the use of bacterial, yeast and microalgae biomass as feed supplements, probiotics and immunostimulants. In some cases, marine microalgae have been employed as sustainable alternatives to fish oil and fish meal without compromising on nutritional quality. Their inclusion in aquaculture feed have enhanced growth, favoured better survival of cultured species and improved water quality parameters. Marine microorganisms (by providing effective bioactive compounds and being used as feed supplements) could enable aquaculture practices to be more sustainable in the future.

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Antioxidant and Anticholinesterase Activities of Macrosphyra Longistyla (DC) Hiern Relevant in the Management of Alzheimer’s Disease

2019

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Macrosphyra longistyla has been used in many traditional systems of medicine for its anti-hemorrhagic, antidiabetic, anti-ulcer, and anti-diarrhea properties. The acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitions of the crude methanol extracts and its various partitioned fractions were determined by a modified method of Ellman. An evaluation of the antioxidant activity was carried out using 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging, ferric reducing power, and nitric oxide scavenging assays. The total flavonoids were estimated based on the aluminum chloride method, while the total tannins and phenolics were estimated based on the vanillin–HCl and Folin–Ciocalteu method, respectively. The ethyl acetate fraction had the highest DPPH radical scavenging activity, and the highest ferric reducing power with a concentration providing 50% inhibition (IC50) of 0.079 mg/mL and 0.078 mg/mL, respectively, while the crude methanol extract had the highest nitric oxide scavenging activity with an IC50 of 0.008 mg/mL. The methanol extract had the highest phenolics and flavonoids contents, while the aqueous fraction had the highest tannin content. The crude methanol extract had the best AChE and BuChE inhibitory action, with an IC50 of 0.556 µg/mL and 5.541 µg/mL, respectively, suggesting that the plant had a better AChE inhibiting potential. A moderate correlation was observed between the phenolic content and DPPH radical scavenging, NO radical scavenging, and AChE inhibitory activities (r2 = 0.439, 0.430, and 0.439, respectively), while a high correlation was seen between the flavonoid content and these activities (r2 = 0.695, 0.724, and 0.730, respectively), and the ferric reducing antioxidant power correlated highly with the proautocyanidin content (r2 = 0.801). Gas chromatography mass spectrometry (GCMS) revealed decanoic acid methyl ester (24.303%), 11,14-eicosadienoic acid methyl ester (16.788%), linoelaidic acid (10.444%), pentadecanoic acid (9.300%), and 2-methyl-hexadecanal (9.285%). Therefore, we suggest that M. longistyla contain bioactive chemicals, and could be a good alternative for the management of Alzheimer’s and other neurodegenerative diseases.

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Marine Biodiversity As a Resource for Bioactive Molecules As Inhibitors of Microbial Quorum Sensing Phenotypes

Cited by 3 publications

References 86 publications

Saline Environments as a Source of Potential Quorum Sensing Disruptors to Control Bacterial Infections: A Review

Saline Environments as a Source of Potential Quorum Sensing Disruptors to Control Bacterial Infections: A Review

Use of marine microorganisms in designing anti-infective strategies for sustainable aquaculture production

Antioxidant and Anticholinesterase Activities of Macrosphyra Longistyla (DC) Hiern Relevant in the Management of Alzheimer’s Disease

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