2014
DOI: 10.1016/b978-0-12-411565-1.00001-9
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Marine Bi-, Bis-, and Trisindole Alkaloids

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Cited by 18 publications
(14 citation statements)
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References 134 publications
(340 reference statements)
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“…Marine natural products show potent activity and selectivity against a wide spectrum of pharmacological targets and their unprecedented structures are often an important source of lead compounds in drug discovery and development [6]. Among the various structural classes, the marine bisindole alkaloids, dimers of indole typically produced by marine sponges [7,8], have received much attention due to their significant cytotoxicity, antineoplastic activity, as well as antimicrobial and antibiofilm activity [9,10,11]. Notably, 2,2-bis(6-bromo-3-indolyl)ethylamine (compound 1 ) (Figure 1), isolated from the Californian tunicate Didemnum candidum and the New Caledonian sponge Orina spp.…”
Section: Introductionmentioning
confidence: 99%
“…Marine natural products show potent activity and selectivity against a wide spectrum of pharmacological targets and their unprecedented structures are often an important source of lead compounds in drug discovery and development [6]. Among the various structural classes, the marine bisindole alkaloids, dimers of indole typically produced by marine sponges [7,8], have received much attention due to their significant cytotoxicity, antineoplastic activity, as well as antimicrobial and antibiofilm activity [9,10,11]. Notably, 2,2-bis(6-bromo-3-indolyl)ethylamine (compound 1 ) (Figure 1), isolated from the Californian tunicate Didemnum candidum and the New Caledonian sponge Orina spp.…”
Section: Introductionmentioning
confidence: 99%
“… 8 , 9 Among the various structural classes, the marine bisindole alkaloids have received much attention due to the significant cytotoxicity, antineoplastic and antimicrobial activities. 10 In particular, 2,2-bis(6- bromo-3-indolyl) ethylamine (BrBIn, Figure 1 ), isolated from the Californian tunicate Didemnum candidum and the New Caledonian sponge Orina , 11 , 12 has shown high cytotoxicity against several tumor cell lines such as U937 human leukemia, 13 MCF-7 human breast and Caco-2 human epithelial colorectal cells. 14 …”
Section: Introductionmentioning
confidence: 99%
“…According to Lee and Lee [35], indole is an intercellular signal chemical in gram positive (+) and gram negative (-) bacteria and has been shown to control a number of bacterial processes such as spore formation, plasmid stability, drug resistance, biofilm formation, and virulence. Moreover, it has been reported that indole can form dimers through carbon-carbon, carbon-nitrogen, or nitrogen-nitrogen linkage to form a small class of biindol marine alkaloids with cytotoxicity against cancer cell lines [36]. Likewise, Atanasova [37], reported the design and prediction of new derivatives of galantamine with the indole molecule in the lateral chain to inhibit the activity of the enzyme AChE.…”
Section: Discussionmentioning
confidence: 99%