Marine antioxidants

Miyashita, Kazuo

doi:10.1002/9781118855102.ch8

Cited by 11 publications

(4 citation statements)

References 88 publications

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“…Mactanamide, for example, presents interesting inhibitive effect vs osteoclastogenesis, and this may lead to therapeutic drug applications. Antioxidant activity was also reported for the compounds present in the extract of sponges, algae, and cyanobacteria. ,− Some of the marine products also present UVR filtering and photoprotective activities. , …”

Section: Introductionmentioning

confidence: 96%

Insight into Antioxidant and Photoprotective Properties of Natural Compounds from Marine Fungus

Dao

Phan

Nguyen

et al. 2020

J. Chem. Inf. Model.

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This computational and experimental work aims to elucidate physicochemical and photophysical natures of free radical scavenging and ultraviolet radiation (UVR) filtering activities of five terpenoids available in the extract of marine fungus. The antioxidant activities of ochraceopone F (C1), aspertetranone D (C2), cycloechinulin (C3), wasabidienone E (C4), and mactanamide (C5) are evaluated by using density functional theory (DFT) at the M05-2X/6-311++G(d,p) level of theory in the gas phase, water, and pentyl ethanoate (PEA). Double antioxidant mechanisms allowing the second (H + /e − ) donation such as double hydrogen atom transfer (dHAT), double single electron transfer-proton transfer (dSET-PT), and double sequential proton loss-electron transfer (dSPL-ET) are considered. Reaction enthalpies (Δ r H 0 ), standard Gibbs free energies (Δ r G 0 ) and potential energy surfaces of reactions toward HOO • radical are then established to evaluate the hydrogen transfer (HT) and radical adduct formation (RAF) mechanisms. The computational results are supported by DPPH • and ABTS •+ antioxidant essays. Results show that all compounds C1−C5 are able to scavenge two free radicals via dHAT, dSET-PT, and dSPL-ET mechanisms. Among the compounds, C3 and C4 represent the most potential antioxidants, especially via HAT and RAF mechanisms in all the reaction media. Their rate constants for both HAT and RAF reactions are remarkably higher than that of Trolox and ascorbic acid. The kinetic calculations on activation Gibbs free energies (ΔG ⧧ ) and rate constants (k TST ) based on conventional transition state theory (TST) reveal that HAT and RAF processes are in competition in solvents. Photophysical processes occurring during UVR exposure are investigated using the time dependent density functional theory (TD-DFT) combined with UV−vis experiments. The obtained results highlight the promising activities of C1−C5 in UVR absorption in the ranges of UVA and UVB. Among them, C3 and C4 also show better UV absorption properties with the easiest excitations (band gaps equal to 4.06 and 3.65 eV). This study suggests the natural candidates possibly used in organic sunscreen.

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Section: Introductionmentioning

confidence: 96%

Insight into Antioxidant and Photoprotective Properties of Natural Compounds from Marine Fungus

Dao

Phan

Nguyen

et al. 2020

J. Chem. Inf. Model.

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“…Physical processes, in which the excess energy of singlet oxygen is transmitted to the carotenoid, have been primarily attributed to the quenching of singlet oxygen by carotenoids. Chemical interactions between excited oxygens and carotenoids are not as significant as physical quenching, accounting for less than 0.05 percent of the total quenching rate [22,26,27]. This trait against ROS has sparked a lot of research on the potential antioxidant properties of carotenoids and their consequent mechanisms, as well as the accumulation of the compounds from sustainable sources at a sufficient rate for nutritional and medicinal applications.…”

Section: Carotenoidsmentioning

confidence: 99%

Innovative Bioactive Products with Medicinal Value from Microalgae and Their Overall Process Optimization through the Implementation of Life Cycle Analysis—An Overview

Papadaki,

Tricha,

Panagiotopoulou

et al. 2024

Marine Drugs

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Microalgae are being recognized as valuable sources of bioactive chemicals with important medical properties, attracting interest from multiple industries, such as food, feed, cosmetics, and medicines. This review study explores the extensive research on identifying important bioactive chemicals from microalgae, and choosing the best strains for nutraceutical manufacturing. It explores the most recent developments in recovery and formulation strategies for creating stable, high-purity, and quality end products for various industrial uses. This paper stresses the significance of using Life Cycle Analysis (LCA) as a strategic tool with which to improve the entire process. By incorporating LCA into decision-making processes, researchers and industry stakeholders can assess the environmental impact, cost-effectiveness, and sustainability of raw materials of several approaches. This comprehensive strategy will allow for the choosing of the most effective techniques, which in turn will promote sustainable practices for developing microalgae-based products. This review offers a detailed analysis of the bioactive compounds, strain selection methods, advanced processing techniques, and the incorporation of LCA. It will serve as a valuable resource for researchers and industry experts interested in utilizing microalgae for producing bioactive products with medicinal properties.

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“…The induction of UCP1 in abdominal WAT by fucoxanthin intake is in part attributed to the upregulation of β3 adrenergic receptor. This receptor is recognized for its involvement in processes such as lipolysis and thermogenesis [53,54], contributing to the oxidative breakdown of fatty acids and heat generation within mitochondria of WAT [52]. Consequently, it can be inferred that the allenic moieties and hydroxyl substituents present in the side chain play a significant role in the regulation of UCP1 expression within white adipose tissue.…”

Section: Sargassum Vulgarementioning

confidence: 99%

Recent Progress in Understanding the Impact of Food Processing and Storage on the Structure–Activity Relationship of Fucoxanthin

Gomez-Zavaglia,

Barros,

Prieto

et al. 2023

Foods

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Fucoxanthin, a brown algae carotenoid, has attracted great interest because of its numerous biological activities supported by in vitro and in vivo studies. However, its chemical structure is susceptible to alterations when subjected to food processing and storage conditions, such as heat, oxygen, light, and pH changes. Consequently, these conditions lead to the formation of fucoxanthin derivatives, including cis-isomers, apo-fucoxanthinone, apo-fucoxanthinal, fucoxanthinol, epoxides, and hydroxy compounds, collectively known as degradation products. Currently, little information is available regarding the stability and functionality of these fucoxanthin derivatives resulting from food processing and storage. Therefore, enhancing the understanding of the biological effect of fucoxanthin derivatives is crucial for optimizing the utilization of fucoxanthin in various applications and ensuring its efficacy in potential health benefits. To this aim, this review describes the main chemical reactions affecting the stability of fucoxanthin during food processing and storage, facilitating the identification of the major fucoxanthin derivatives. Moreover, recent advancements in the structure–activity relationship of fucoxanthin derivatives will be critically assessed, emphasizing their biological activity. Overall, this review provides a critical updated understanding of the effects of technological processes on fucoxanthin stability and activity that can be helpful for stakeholders when designing processes for food products containing fucoxanthin.

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Marine antioxidants

Cited by 11 publications

References 88 publications

Insight into Antioxidant and Photoprotective Properties of Natural Compounds from Marine Fungus

Insight into Antioxidant and Photoprotective Properties of Natural Compounds from Marine Fungus

Innovative Bioactive Products with Medicinal Value from Microalgae and Their Overall Process Optimization through the Implementation of Life Cycle Analysis—An Overview

Recent Progress in Understanding the Impact of Food Processing and Storage on the Structure–Activity Relationship of Fucoxanthin

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