Marine Antifreeze Proteins: Structure, Function, and Application to Cryopreservation as a Potential Cryoprotectant

Kim, Soo Hyun; Lee, Jun Hyuck; Hur, Young Baek; Lee, Chang Woo; Park, Sunha; Koo, Bonjae

doi:10.3390/md15020027

Cited by 135 publications

(103 citation statements)

References 207 publications

(368 reference statements)

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“…The role of antifreeze proteins in freeze tolerance is unclear and little is generally known about invertebrate antifreeze proteins (Davies, 2014; H. J. Kim et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Transcriptional dynamics following freezing stress reveal selection for mechanisms of freeze tolerance at the poleward range margin in the cold water intertidal barnacleSemibalanus balanoides

Marshall

Dowle

Petrunina

et al. 2018

Preprint

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Transcriptional dynamics following freezing stress reveal selection for mechanisms of freeze 3 tolerance at the poleward range margin in the cold water intertidal barnacle Semibalanus 4 balanoides 5 6 Running title: Transcription following freezing in S. balanoides 7 Abstract 22The ability to survive freezing has repeatedly evolved across multiple phyla. This suggests that 23 the mechanisms of freeze tolerance must be readily evolvable from basal physiological traits. 24While several biochemical correlates to freeze tolerance have been described, the mechanism that 25 confers freeze tolerance is still not well understood. To understand both the basic biochemical 26 mechanisms of freeze tolerance as well as their role in local adaptation at the poleward range 27 edge, we conducted a transcriptomic study on two populations (one from the poleward range 28 margin in the White Sea, Russia, and one from the central coast of British Columbia, Canada) of 29 the cold water acorn barnacle Semibalanus balanoides on a time series following a freezing 30 event. We found that the British Columbia population (at the equatorward range margin) was 31 significantly less freeze tolerant than the White Sea population (at the poleward range margin). 32After assembling and annotating a de novo transcriptome for S. balanoides, we found that the 33 patterns of differential transcript expression following freezing were almost entirely non-34 overlapping between the two populations, with the White Sea population expressing a series of 35 heat shock proteins in response to freezing stress as well as several aquaporins, while the British 36 Columbia population expressed a series of proteases instead, indicating severe protein damage. 37 We found strong evidence of purifying selection on the significantly upregulated transcripts in 38 the White Sea population, suggesting local adaptation to freezing threat. Taken together, this 39 shows the importance of freeze tolerance to population survival at the poleward range margin, 40 and highlights the central roles of aquaporins and heat shock proteins to the trait of freeze 41 tolerance across taxa. 42

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“…The role of antifreeze proteins in freeze tolerance is unclear and little is generally known about invertebrate antifreeze proteins (Davies, 2014; H. J. Kim et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Transcriptional dynamics following freezing stress reveal selection for mechanisms of freeze tolerance at the poleward range margin in the cold water intertidal barnacleSemibalanus balanoides

Marshall

Dowle

Petrunina

et al. 2018

Preprint

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“…The production of AFPs from different organisms is the result of convergent evolution through the pressure of extreme cold temperature. The AFPs are reported for other industrial applications too [82,83].…”

Section: Bioprospection Of Cold-tolerant Microbes: Versatile and Prommentioning

confidence: 99%

Microbial Ecology from the Himalayan Cryosphere Perspective

Dhakar

Pandey

2020

Microorganisms

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Cold-adapted microorganisms represent a large fraction of biomass on Earth because of the dominance of low-temperature environments. Extreme cold environments are mainly dependent on microbial activities because this climate restricts higher plants and animals. Himalaya is one of the most important cold environments on Earth as it shares climatic similarities with the polar regions. It includes a wide range of ecosystems, from temperate to extreme cold, distributed along the higher altitudes. These regions are characterized as stressful environments because of the heavy exposure to harmful rays, scarcity of nutrition, and freezing conditions. The microorganisms that colonize these regions are recognized as cold-tolerant (psychrotolerants) or/and cold-loving (psychrophiles) microorganisms. These microorganisms possess several structural and functional adaptations in order to perform normal life processes under the stressful low-temperature environments. Their biological activities maintain the nutrient flux in the environment and contribute to the global biogeochemical cycles. Limited culture-dependent and culture-independent studies have revealed their diversity in community structure and functional potential. Apart from the ecological importance, these microorganisms have been recognized as source of cold-active enzymes and novel bioactive compounds of industrial and biotechnological importance. Being an important part of the cryosphere, Himalaya needs to be explored at different dimensions related to the life of the inhabiting extremophiles. The present review discusses the distinct facts associated with microbial ecology from the Himalayan cryosphere perspective.

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“…Because of the special cryoprotective activity of AFPs, their development and application have recently attracted extensive attention. For example, AFP has potential commercial applications in frozen food processing and storage, cell preservation, organ transplantation, and cryosurgery (Kim et al., ). As a novel food additive, the application of AFPs in food industries has been widely reported (Gaukel, Leiter, & Spieß, ; Ustun & Turhan, ; Wang, Agyare, & Damodaran, ; Zhang et al., ).…”

Section: Introductionmentioning

confidence: 99%

Intracellular Expression of Antifreeze Peptides in Food Grade Lactococcus lactis and Evaluation of Their Cryoprotective Activity

Zhang

Jin

Luo

et al. 2018

Journal of Food Science

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Marine Antifreeze Proteins: Structure, Function, and Application to Cryopreservation as a Potential Cryoprotectant

Cited by 135 publications

References 207 publications

Transcriptional dynamics following freezing stress reveal selection for mechanisms of freeze tolerance at the poleward range margin in the cold water intertidal barnacleSemibalanus balanoides

Transcriptional dynamics following freezing stress reveal selection for mechanisms of freeze tolerance at the poleward range margin in the cold water intertidal barnacleSemibalanus balanoides

Microbial Ecology from the Himalayan Cryosphere Perspective

Intracellular Expression of Antifreeze Peptides in Food Grade Lactococcus lactis and Evaluation of Their Cryoprotective Activity

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