Marine and Soil Fungi Extracts with Antiproliferative Activity Induce Morphological Alterations in Breast Cancer Cells

Ramos, Altina; Malhão, Fernanda; Ferreira, Ana M.; Alves, Ângela; Castro‐Carvalho, Bruno; Prata‐Sena, Maria; Gargiulo, Daniela Longo; Dethoup, Tida; Buttachon, Suradet; Lobo-da-Cunha, Alexandre; Kijjoa, Anake; Rocha, Eduardo

doi:10.1017/s1431927615014221

Cited by 2 publications

(1 citation statement)

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“…They have been found to be active both in vitro and in vivo. Thiosemicarbazone is a class of organic compounds that possesses a wide spectrum of biological, especially antiproliferative, activities (Abreu Ramos et al, 2015) and medical properties (Majumdar & Valdellon, 1999).…”

Section: Introductionmentioning

confidence: 99%

Biological Evaluation of a Series of Amine-Containing Mixed-Ligand Copper(II) Coordination Compounds with 2-(2-hydroxybenzylidene)-N-(prop-2-en-1-yl)hydrazinecarbothioamide

Gulea

Toderaş

Garbuz

et al. 2022

Microscopy and Microanalysis

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Five compounds 2-(2-hydroxybenzylidene)-N-(prop-2-en-1-yl)hydrazinecarbothioamide (H2L), bis[μ2-2-({2-[(prop-2-en-1-yl)carbamothioyl]hydrazinylidene}methyl)phenolato-S,N,O:O]diaquadicopper(II) nitrate (1), bis[μ2-2-({2-[(prop-2-en-1-yl)carbamothioyl]hydrazinylidene}methyl)phenolato-S,N,O:O]diimidazoldicopper(II) nitrate (2), bis[μ2-2-({2-[(prop-2-en-1-yl)carbamothioyl]-hydrazinylidene}methyl)phenolato-S,N,O:O]bis-(3,5-dibromopyridine)dicopper(II) nitrate (3), bis[μ2-2-({2-[(prop-2-en-1-yl)carbamothioyl]-hydrazinylidene}methyl)phenolato-S,N,O:O]bis(4-methylpyridine)dicopper(II) nitrate hexahydrate (4) were synthesized. The antiproliferative properties of these compounds toward cancer cell lines RD, HeLa, and normal cell line MDCK have been investigated. The tested complexes surpass Doxorubicin (DOXO) in the efficiency of anticancer activity as their IC50 values toward cancer cells are lower than the corresponding values of DOXO and the selectivity indexes exceed the corresponding SI value of DOXO. The tested compounds demonstrated a high antioxidant effect against ABTS • + radical cations as well as low toxicity on Daphnia magna.

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Section: Introductionmentioning

confidence: 99%