Marine alkaloids—6. The first naturally occurring bromo-substituted quinoline from Flustra foliacea

Wulff, Peter; CARLE, J. S.; Christophersen, Carsten

doi:10.1016/0305-0491(82)90421-7

Cited by 12 publications

(11 citation statements)

References 3 publications

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“…Final structural proof was obtained by oxidation of 1 with m-chloroperoxybenzoic acid to yield a product with identical chromatographic (tlc and hplc) and spectroscopic properties (uv and 'H nmr) to the naturally occurring N-oxide. 4 This unstable compound was isolated as a very minor constituent of the alkaloid mixture. Except for a few resonances, the 'H nmr spectrum of this material was very similar to that of flustramine D, 3 (Table 1).…”

Section: Dihydrojustramine C N-oxidementioning

confidence: 99%

New physostigmine related bromoalkaloids from the marine bryozoan Flustrafoliacea

Laycock¹,

Wright²,

Findlay³

et al. 1986

Can. J. Chem.

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Section: Dihydrojustramine C N-oxidementioning

confidence: 99%

New physostigmine related bromoalkaloids from the marine bryozoan Flustrafoliacea

Laycock¹,

Wright²,

Findlay³

et al. 1986

Can. J. Chem.

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“…The possible mechanism is that pterocellin A is an inducer of apoptosis in Hela cells via mitochondria related processes [77]. Wulff et al first discovered a new naturally occurring bromo-substituted quinoline alkaloid (133) from F. foliacea [78]. Subsequently, three isoquinolintriones were isolated from Biflustra perfragilis, which have been reviewed by Blackman et al [49].…”

Section: Other Types Of Alkaloidsmentioning

confidence: 99%

Review of Bioactive Secondary Metabolites from Marine Bryozoans in the Progress of New Drugs Discovery

et al. 2018

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Marine bryozoans play an important role for the discovery of novel bioactive compounds among marine organisms. In this review, we summarize 164 new secondary metabolites including macrocyclic lactones, sterols, alkaloids, sphingolipids and so forth from 24 marine bryozoans in the last two decades. The structural features, bioactivity, structure-activity relationship, mechanism and strategies to address the resupply of these scarce secondary metabolites are discussed. The structural and bioactive diversity of the secondary metabolites from marine bryozoans indicated the possibility of using these compounds, especially bryostatin 1 (1), bryostatin analog (BA1), alkaloids (50, 53, 127-128 and 134-139), sphingolipids sulfates (148 and 149) and sulfur-containing aromatic compound (160), as the starting points for new drug discovery.

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“…Both species belong to the Flustridae family (Order: Cheilostomata). Many of the Cheilostome bryozoans including S. securifrons , C. papyracea , and Flustra foliacea are producing indole alkaloids and brominated alkaloids [ 12 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 ]. However, the isolated new brominated alkaloid, Securidine A ( 1 ) is a novel structure ( Figure 1 ), which is not structurally similar to any other listed compounds of S. securifrons.…”

Section: Introductionmentioning

confidence: 99%

A Novel Brominated Alkaloid Securidine A, Isolated from the Marine Bryozoan Securiflustra securifrons

et al. 2017

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A novel brominated alkaloid, Securidine A, was isolated from the cold water marine bryozoan Securiflustra securifrons. Securidine A was isolated using semi-preparative HPLC, and the structure was elucidated by spectroscopic methods. The isolated Securidine A was tested for cytotoxic, antibacterial, and anti-diabetic activities as well as for its potential for inhibition of biofilm formation. No significant biological activity was observed in the applied bioassays, thus expanded bioactivity profiling is required, in order to reveal any potential applications for Securidine A.

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Marine alkaloids—6. The first naturally occurring bromo-substituted quinoline from Flustra foliacea

Cited by 12 publications

References 3 publications

New physostigmine related bromoalkaloids from the marine bryozoan Flustrafoliacea

New physostigmine related bromoalkaloids from the marine bryozoan Flustrafoliacea

Review of Bioactive Secondary Metabolites from Marine Bryozoans in the Progress of New Drugs Discovery

A Novel Brominated Alkaloid Securidine A, Isolated from the Marine Bryozoan Securiflustra securifrons

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