Marine Actinobacteria as a Source for Emerging Biopharmaceuticals

Kannan, K.; Sivaperumal, P.; Kamath, S. Manjunath; Thilagaraj, Wilson Richard; Rajendran, R.

doi:10.1002/9781119143802.ch93

Cited by 5 publications

(3 citation statements)

References 65 publications

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“…Similar to Proteobacteria, several studies demonstrated the great biotechnological potential of Actinobacteria, especially those belonging to the Streptomyces genus. In fact, several bioactive compounds with antimicrobial, antiviral, antiparasitic, antiprotozoal and antitumor effects have been described [ 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 ]. Moreover, genomic analyses revealed some BGCs encoding for secondary metabolites, such as PKS I and III, NRPS (nonribosomal peptides), terpene and bacteriocin gene clusters from a sponge-derived Actinobacteria showing antimicrobial activities [ 108 , 109 , 110 , 111 , 112 ].…”

Section: Discussionmentioning

confidence: 99%

A Metataxonomic Approach Reveals Diversified Bacterial Communities in Antarctic Sponges

et al. 2021

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Marine sponges commonly host a repertoire of bacterial-associated organisms, which significantly contribute to their health and survival by producing several anti-predatory molecules. Many of these compounds are produced by sponge-associated bacteria and represent an incredible source of novel bioactive metabolites with biotechnological relevance. Although most investigations are focused on tropical and temperate species, to date, few studies have described the composition of microbiota hosted by Antarctic sponges and the secondary metabolites that they produce. The investigation was conducted on four sponges collected from two different sites in the framework of the XXXIV Italian National Antarctic Research Program (PNRA) in November–December 2018. Collected species were characterized as Mycale (Oxymycale) acerata, Haliclona (Rhizoniera) dancoi, Hemigellius pilosus and Microxina sarai by morphological analysis of spicules and amplification of four molecular markers. Metataxonomic analysis of these four Antarctic sponges revealed a considerable abundance of Amplicon Sequence Variants (ASVs) belonging to the phyla Proteobacteria, Bacteroidetes, Actinobacteria and Verrucomicrobia. In particular, M. (Oxymycale) acerata, displayed several genera of great interest, such as Endozoicomonas, Rubritalea, Ulvibacter, Fulvivirga and Colwellia. On the other hand, the sponges H. pilosus and H. (Rhizoniera) dancoi hosted bacteria belonging to the genera Pseudhongella, Roseobacter and Bdellovibrio, whereas M. sarai was the sole species showing some strains affiliated to the genus Polaribacter. Considering that most of the bacteria identified in the present study are known to produce valuable secondary metabolites, the four Antarctic sponges could be proposed as potential tools for the discovery of novel pharmacologically active compounds.

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Section: Discussionmentioning

confidence: 99%

A Metataxonomic Approach Reveals Diversified Bacterial Communities in Antarctic Sponges

et al. 2021

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“…Cyclomarins A, B, and C are three ring-shaped heptapeptides isolated from marine actinomycetes, such as Streptomyces sp. Cyclomarin A is composed of three common amino acids and four unusual amino acids and has shown anti-inflammatory and anticellular activity in laboratory studies [117,118]. Salinamides A-E are types of peptides that have been extracted from Streptomyces sp.…”

Section: Meat Productsmentioning

confidence: 99%

Bioactive Peptides: Synthesis, Sources, Applications, and Proposed Mechanisms of Action

Akbarian

Ali

Eghbalpour

et al. 2022

IJMS

212

126

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Bioactive peptides are a group of biological molecules that are normally buried in the structure of parent proteins and become active after the cleavage of the proteins. Another group of peptides is actively produced and found in many microorganisms and the body of organisms. Today, many groups of bioactive peptides have been marketed chemically or recombinantly. This article reviews the various production methods and sources of these important/ubiquitous and useful biomolecules. Their applications, such as antimicrobial, antihypertensive, antioxidant activities, blood-lipid-lowering effect, opioid role, antiobesity, ability to bind minerals, antidiabetic, and antiaging effects, will be explored. The types of pathways proposed for bioactive applications will be in the next part of the article, and at the end, the future perspectives of bioactive peptides will be reviewed. Reading this article is recommended for researchers interested in various fields of physiology, microbiology, biochemistry, and nanotechnology and food industry professionals.

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“…Himalomycins A and B, two new quinone antibiotics with potent antibacterial activity, were isolated from the Streptomyces isolate B6921 [ 21 , 22 ], and whole komodoquinone A, a neuritogenic anthracycline, was isolated from the fermentation broth of Streptomyces sp. KS3 [ 23 , 24 ]. Because of their interesting biological activities and complex molecular architectures, the naturally occurring quinone rubromycin family has attracted the attention of a number of research groups over the last sixty years [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Streptomyces iakyrus TA 36 as First-Reported Source of Quinone Antibiotic γ–Rubromycin

et al. 2023

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A wide range of bioactive compounds with potential medical applications are produced by members of the genus Streptomyces. A new actinomycete producer of the antibiotic γ-rubromycin, designated TA 36, was isolated from an alpine soil sample collected in Peru (Machu Picchu). Morphological, physiological and biochemical characteristics of the strain, together with data obtained via phylogenetic analysis and MALDI-TOF MS, were used for the correct identification of the isolate. The isolate TA 36 showed morphological characteristics that were consistent with its classification within the genus Streptomyces. Phylogenetic analysis based on 16S rRNA gene sequences showed that the TA 36 strain was most similar to S. iakyrus and S. violaceochromogenes with 99% similarity. Phylogenetic analysis together with the profile of whole cell proteins indicated that the strain tested could be identified as S. iakyrus TA 36. The crude extract Ext.5333.TA 36 showed various effects against the tested organisms with strong antimicrobial activity in the growth of Staphylococcus aureus (Newman) (MIC value of 0.00195 µg/µL). HPLC fractionation and LC/MS analysis of the crude extract led to the identification of the quinone antibiotic γ-rubromycin, a promising antitumour and antibacterial antibiotic. To the best of our knowledge, there is currently no report on the production of γ-rubromycin by S. iakyrus. Therefore, this study suggests S. iakyrus TA 36 as the first-reported source of this unique bioactive secondary metabolite.

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Marine Actinobacteria as a Source for Emerging Biopharmaceuticals

Cited by 5 publications

References 65 publications

A Metataxonomic Approach Reveals Diversified Bacterial Communities in Antarctic Sponges

A Metataxonomic Approach Reveals Diversified Bacterial Communities in Antarctic Sponges

Bioactive Peptides: Synthesis, Sources, Applications, and Proposed Mechanisms of Action

Streptomyces iakyrus TA 36 as First-Reported Source of Quinone Antibiotic γ–Rubromycin

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