Marine actinobacteria: An important source of bioactive natural products

Manivasagan, Panchanathan; Kang, Kyong‐Hwa; Sivakumar, K.; Li‐Chan, Eunice C.Y.; Oh, Hyun-Myung; Kim, Se‐Kwon

doi:10.1016/j.etap.2014.05.014

Cited by 126 publications

(88 citation statements)

References 74 publications

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“…The marine environment is not yet fully explored, it is a huge treasure trove of marine actinobacteria resources [13,14]. Nowadays, marine actinobacteria are the best sources of secondary metabolites with various biological activities.…”

Section: Introductionmentioning

confidence: 99%

Production of polysaccharide-based bioflocculant for the synthesis of silver nanoparticles by Streptomyces sp

Manivasagan

Kang

Kim

et al. 2015

International Journal of Biological Macromolecules

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Section: Introductionmentioning

confidence: 99%

Production of polysaccharide-based bioflocculant for the synthesis of silver nanoparticles by Streptomyces sp

Manivasagan

Kang

Kim

et al. 2015

International Journal of Biological Macromolecules

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“…Doxorubicin (adriamycin) and daunorubicin (daunomycin or rubidomycin) are two members of anthracycline group 10 . These two drugs are obtained from actinobacteria 'Streptomyces peucetius' 11 . Anthracycline-induced cardiotoxicity can be acute, just after treatment which can be an arrhythmia, myocarditis, pericarditis or acute left ventricular failure.…”

Section: Anthracycline and Cardiotoxicitymentioning

confidence: 99%

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2018

IJPSR

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Cardiotoxicity associated with the clinically used drugs is a global concern of safety for healthcare professionals. Various animal models have been used to study the drug-induced cardiotoxicity but the exact molecular involvement of toxicity is not much clear. Despite the recurrent occurrence of toxicities, drugs such as doxorubicin, calcium channel blockers, antiarrhythmics and immunomodulators are regularly used. Anticancer drugs mainly anthracyclines, 5-fluorouracil and cyclophosphamide exert prominent cardiotoxicity. Till date, there is only one drug approved for doxorubicin-related cardiotoxicity i.e. dexrazoxane. Few other drugs are used routinely by clinicians to reduce the severity of toxicity which includes ACE inhibitors, L-carnitine, probucol, CoQ 10 , N-acetylcysteine, Vitamin E and deferoxamine, whereas antidepressants drugs, specifically tricyclic antidepressants are potential candidates for cardiotoxicity. Calcium channel blockers, antiarrhythmic and beta receptor antagonist aggravate cardiac heart failure (CHF) and left ventricular arrhythmia. Interferons, mainly interferon-α is also associated with prominent and dose-dependant toxicity. Some other drugs like zidovudine, chloroquine, cocaine, minoxidil, ketoconazole, prostaglandin E2 and anagrelide are also reported to have cardiotoxic effects. A complication associated with the use of these drugs include hypoxia, coronary ischemia, calcium overload, oxidative stress, contractile dysfunction, left ventricular arrhythmia and cardiomyopathy.

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“…Since the discovery of rifamycin from Streptomyces mediterranei isolated from the beachside town of St Raphael in southern France in 1957, [1][2][3] actinomycetes from various marine ecosystems have been found to produce many bioactive compounds with potential clinical application. In recent years, the exciting finding of the first novel obligate marine actinomycetes genus Salinispora and the clinical candidate salinosporamide A for the treatment of cancer, produced by S. tropica, [4][5][6][7] attracted more attention to marine actinomycete sources and provided a new direction for microorganism-based drug discovery.…”

Section: Introductionmentioning

confidence: 99%

Isolation, Stereochemical Study, and Cytotoxic Activity of Isobenzofuran Derivatives From a Marine Streptomyces sp.

Zhang

Shen

et al. 2014

Chirality

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A new 1,3-dihydroisobenzofuran derivative (), together with its epimer (), was isolated from marine Streptomyces sp. W007. The structure of the two compounds was established by extensive spectroscopic analysis and comparison with reported data. The absolute configurations of and were determined by a combination of experimental and computational means, including J-coupling analysis and nuclear Overhauser effect spectroscopy (NOESY) spectra, nuclear magnetic resonance (NMR) calculations, electronic circular dichroism (ECD), and optical rotation (OR) calculations. Compound had no cytotoxicity against human lung adenocarcinoma cell line A549, while compound exhibited weak activity, suggesting that the biological activity depends on the configuration of a single chirality center.

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Marine actinobacteria: An important source of bioactive natural products

Cited by 126 publications

References 74 publications

Production of polysaccharide-based bioflocculant for the synthesis of silver nanoparticles by Streptomyces sp

Production of polysaccharide-based bioflocculant for the synthesis of silver nanoparticles by Streptomyces sp

Untitled

Isolation, Stereochemical Study, and Cytotoxic Activity of Isobenzofuran Derivatives From a Marine Streptomyces sp.

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