“…Since then, e-cigarettes have emerged as a major new concern in public and youth health, with evidence suggesting that use among youth is on the rise ( Government of Canada, 2017 , Government of Canada, 2018 ), and that their co-use with other substances is particularly common ( Barnett, Soule, Forrest, Porter, & Tomar, 2015 ; Giroud et al, 2015 ; Hammond, Reid, Cole, & Leatherdale, 2017 ; National Academies of Sciences Engineering and Medicine, 2018 ; Richter, Pugh, Smith, & Ball, 2017 ). The recent legalization of cannabis (October 2018) may further increase the risk of youth poly-substance use, even though its use remains illegal for this age group ( Ammerman, Ryan, & Adelman, 2015 ; MacCoun & Reuter, 1997 ; Palamar, Ompad, & Petkova, 2014 ; Rusby, Westling, Crowley, & Light, 2018 ; Stolzenberg, D'Alessio, & Dariano, 2016 ; Vigil et al, 2018 ; Wen, Hockenberry, & Cummings, 2015 ; Williams & Bretteville-Jensen, 2014 ). Few current policies, programs, or public health initiatives explicitly target youth poly-substance use, despite evidence that their implementation may have beneficial effects ( Akbar et al, 2011 ; Butt, Beirness, Gliksman, Paradis, & Stockwell, 2011 ; Das, Salam, Arshad, Finkelstein, & Bhutta, 2016 ; Fischer et al, 2017 ; Xuan et al, 2015 ).…”