Marijuana Compounds: A Non-Conventional Therapeutic Approach to Epilepsy in Children

Babayeva, Mariana

doi:10.24966/aad-7276/100002

Cited by 3 publications

(6 citation statements)

References 87 publications

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“…CBD is the major nonpsychoactive ingredient in cannabis and produces neuroprotective and anti-inflammatory effects [73]. Both compounds, TCH and CBD, have anticonvulsant properties [74]. Cannabinoids have also potential to alleviate motor disorders by reducing motor impairments and neuron degeneration [75].…”

Section: Marijuana and Its Influence On The Endocannabinoid Systemmentioning

confidence: 99%

Marijuana Compounds: A Nonconventional Approach to Parkinson’s Disease Therapy

Babayeva

Assefa

Basu

et al. 2016

Parkinson's Disease

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Parkinson's disease (PD), a neurodegenerative disorder, is the second most common neurological illness in United States. Neurologically, it is characterized by the selective degeneration of a unique population of cells, the nigrostriatal dopamine neurons. The current treatment is symptomatic and mainly involves replacement of dopamine deficiency. This therapy improves only motor symptoms of Parkinson's disease and is associated with a number of adverse effects including dyskinesia. Therefore, there is unmet need for more comprehensive approach in the management of PD. Cannabis and related compounds have created significant research interest as a promising therapy in neurodegenerative and movement disorders. In this review we examine the potential benefits of medical marijuana and related compounds in the treatment of both motor and nonmotor symptoms as well as in slowing the progression of the disease. The potential for cannabis to enhance the quality of life of Parkinson's patients is explored.

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Section: Marijuana and Its Influence On The Endocannabinoid Systemmentioning

confidence: 99%

Marijuana Compounds: A Nonconventional Approach to Parkinson’s Disease Therapy

Babayeva

Assefa

Basu

et al. 2016

Parkinson's Disease

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“…The data demonstrated mixed efficacy in various acute seizure animal models [143]. CBD exerts its antiepileptic effects through several different mechanisms.…”

Section: Cannabinoid's Effect On Epilepsy Molecular Targets and Syndr...mentioning

confidence: 97%

“…Studies investigated the effects of cannabinoids on molecular targets in animal models of seizure and epilepsy. The results of these studies are summarized in Table 1 [143].…”

Section: Cannabinoid's Effect On Epilepsy Molecular Targets and Syndr...mentioning

confidence: 99%

Cannabis Compounds: Potential Therapy for Neurological Disease

Babayeva,

G. Loewy

2024

Medicinal Plants - Harnessing the Healing Power of Plants for Health [Working Title]

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Identification and development of pharmaceuticals for neurological disorders is associated with several unique challenges. The primary weakness of candidate neurological compounds is the poor penetration efficacy across the blood-brain barrier (BBB). The BBB is the bottleneck in nervous system drug development and is the paramount factor that limits success in neurotherapeutics. Findings suggest cannabinoids might overcome the limiting effects of the BBB and play a key role in improving neurological dysfunctions. This supports the therapeutic potential of cannabidiol for the treatment of ischemic and inflammatory diseases of the central nervous system (CNS). The potential application of cannabinoids for Parkinson’s disease, Autism, and childhood Epilepsy is explored in this chapter.

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“…The ECS represents a complex system of lipid signaling pathways [59,60]. The ECS plays an important role in the development of the central nervous system (CNS) [61][62][63].…”

Section: Changes In the Endocannabinoid System In Autismmentioning

confidence: 99%

“…Cannabis has an extensive range of clinical applications including treatment of multiple sclerosis, Tourette syndrome, Parkinson's disease, epilepsy, glaucoma, nausea, depression and pain [37,59,60,[147][148][149][150][151]. Epidiolex® (CBD) has been FDA-and EMA-approved for two epilepsy syndromes related to ASD: Dravet and Lennox-Gastaut Syndrome [149,150].…”

Section: Clinical Studiesmentioning

confidence: 99%

Autism and associated disorders: cannabis as a potential therapy

Babayeva¹,

Assefa²,

Basu³

et al. 2022

Front. Biosci. (Elite Ed)

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Autism spectrum disorder (ASD) is a group of disabilities with impairments in physical, verbal, and behavior areas. Regardless the growing frequency of autism, no medicine has been formed for the management of the ASD primary symptoms. The most frequently prescribed drugs are off-label. Therefore, there is necessity for an advance tactic for the treatment of autism. The endocannabinoid system has a central role in ruling emotion and social behaviors. Dysfunctions of the system donate to the behavioral deficits in autism. Therefore, the endocannabinoid system represents a potential target for the development of a novel autism therapy. Cannabis and associated compounds have produced substantial research attention as a capable therapy in neurobehavioral and neurological syndromes. In this review we examine the potential benefits of medical cannabis and related compounds in the treatment of ASD and concurrent disorders.

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Marijuana Compounds: A Non-Conventional Therapeutic Approach to Epilepsy in Children

Cited by 3 publications

References 87 publications

Marijuana Compounds: A Nonconventional Approach to Parkinson’s Disease Therapy

Marijuana Compounds: A Nonconventional Approach to Parkinson’s Disease Therapy

Cannabis Compounds: Potential Therapy for Neurological Disease

Autism and associated disorders: cannabis as a potential therapy

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